Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 10637
TargetGTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556275(US11345701, Compound 2-1)
Affinity DataIC50: 14.5nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556273(US11345701, Compound 1-1)
Affinity DataIC50: 16.6nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556279(US11345701, Compound 5-2 | US11345701, Compound 5-...)
Affinity DataIC50: 17.8nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM50514402(CHEMBL4535757 | US11345701, Compound Amg-510)
Affinity DataIC50: 24.5nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556277(US11345701, Compound 3-1)
Affinity DataIC50: 25.4nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556274(US11345701, Compound 2-2 | 4-((S)-4-acryloyl-2-met...)
Affinity DataIC50: 30.7nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556282(US11345701, Compound 7-1)
Affinity DataIC50: 36.7nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556278(US11345701, Compound 4-1)
Affinity DataIC50: 40.9nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556279(US11345701, Compound 5-2 | US11345701, Compound 5-...)
Affinity DataIC50: 48.8nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556272(US11345701, Compound 1 | 4-((S)-4-acryloyl-2-methy...)
Affinity DataIC50: 70.1nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556274(US11345701, Compound 2-2 | 4-((S)-4-acryloyl-2-met...)
Affinity DataIC50: 681nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556279(US11345701, Compound 5-2 | US11345701, Compound 5-...)
Affinity DataIC50: 774nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent