Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 8690
TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413447(US10407431, Example 34 | 5-(5-amino-2-methoxybenzy...)
Affinity DataEC50:  1nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413415(US10407431, Example 2 | 2-(dimethylamino)ethyl 4-(...)
Affinity DataEC50: <5nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413417(US10407431, Example 4 | methyl 3-((2-amino-4-(pent...)
Affinity DataEC50: <5nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413434(US10407431, Example 21 | 2-(4-methylpiperazin-1-yl...)
Affinity DataEC50: <5nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413429(US10407431, Example 16 | 2-(morpholin-4-yl)-2-oxoe...)
Affinity DataEC50: <5nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413445(US10407431, Example 32 | 5-(2-methoxy-4-(piperazin...)
Affinity DataEC50: <5nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413435(US10407431, Example 22 | 2-hydroxyethyl 2-(4-{[2-a...)
Affinity DataEC50: <6nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413423(US10407431, Example 10 | 2-morpholino-2-oxoethyl 2...)
Affinity DataEC50:  6nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413436(US10407431, Example 23 | 4-(dimethylamino)butyl 2-...)
Affinity DataEC50:  7nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413446(US10407431, Example 33 | (S)-2-((2-amino-5-(2-meth...)
Affinity DataEC50:  7nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413437(US10407431, Example 24 | 2-(morpholin-4-yl)ethyl 2...)
Affinity DataEC50:  8nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413422(US10407431, Example 9 | 2-morpholino-2-oxoethyl 2-...)
Affinity DataEC50:  10nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413418(US10407431, Example 5 | methyl 2-(3-((2-amino-4-(p...)
Affinity DataEC50:  10nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413427(US10407431, Example 14 | (S)-2-morpholino-2-oxoeth...)
Affinity DataEC50:  10nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413414(US10407431, Example 1 | methyl 4-((2-amino-4-(pen...)
Affinity DataEC50:  10nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413426(US10407431, Example 13 | (S)-2-morpholino-2-oxoeth...)
Affinity DataEC50:  10nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413416(US10407431, Example 3 | 2-(2-(dimethylamino)ethoxy...)
Affinity DataEC50:  20nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413428(US10407431, Example 15 | (S)-2-morpholino-2-oxoeth...)
Affinity DataEC50:  20nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413444(US10407431, Example 31 | 5-(2-methoxy-5-(piperazin...)
Affinity DataEC50:  20nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413424(US10407431, Example 11 | 2-(morpholin-4-yl)-2-oxoe...)
Affinity DataEC50:  20nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413419(US10407431, Example 6 | ethyl 3-(3-((2-amino-4-(pe...)
Affinity DataEC50:  30nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413438(US10407431, Example 25 | 2-(piperazin-1-yl)ethyl 2...)
Affinity DataEC50:  30nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413425(US10407431, Example 12 | (S)-2-morpholino-2-oxoeth...)
Affinity DataEC50:  30nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413421(US10407431, Example 8 | 2-morpholino-2-oxoethyl 2-...)
Affinity DataEC50:  40nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413430(US10407431, Example 17 | 2-(morpholin-4-yl)-2-oxoe...)
Affinity DataEC50:  50nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413433(US10407431, Example 20 | 2-(dimethylamino)-2-oxoet...)
Affinity DataEC50:  80nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413443(US10407431, Example 30 | S)-2-((2-amino-5-(2-metho...)
Affinity DataEC50:  80nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413420(US10407431, Example 7 | methyl 2-(3-((2-amino-4-(p...)
Affinity DataEC50:  100nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413431(US10407431, Example 18 | 2-(benzyloxy)-2-oxoethyl ...)
Affinity DataEC50:  200nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413432(US10407431, Example 19 | 2-(dipropylcarbamoyl)meth...)
Affinity DataEC50:  200nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413442(US10407431, Example 29 | 2-(4-methylpiperazin-1-yl...)
Affinity DataEC50:  200nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413439(US10407431, Example 26 | 2-(dimethylamino)ethyl 2-...)
Affinity DataEC50:  300nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413441(US10407431, Example 28 | 2-(morpholin-4-yl)ethyl 2...)
Affinity DataEC50:  400nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Novartis

US Patent
LigandPNGBDBM413440(US10407431, Example 27 | 2-(piperazin-1-yl)ethyl 2...)
Affinity DataEC50:  500nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent