Compile Data Set for Download or QSAR
Report error Found 73 Enz. Inhib. hit(s) with all data for entry = 302
TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263478BDBM263478((s)-2-(6,8-dimethyl-4-oxobenzo[d][1,2,3]triazin-3(...)
Affinity DataKi:  10nM ΔG°:  -42.4kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263499BDBM263499((s)-n-(1-(2-fluoro-4-(trifluoromethyl)phenyl)ethyl...)
Affinity DataKi:  11nM ΔG°:  -42.2kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263461BDBM263461((s)-2-(6,8-dichloro-4-oxobenzo[d][1,2,3]triazin-3(...)
Affinity DataKi:  26nM ΔG°:  -40.2kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263493BDBM263493((s)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3 (4h...)
Affinity DataKi:  26nM ΔG°:  -40.2kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263490BDBM263490((s)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataKi:  33nM ΔG°:  -39.7kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263504BDBM263504((s)-n-(1-(2-fluoro-4-(trifluoromethoxy)phenyl)ethy...)
Affinity DataKi:  33nM ΔG°:  -39.7kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263484BDBM263484((s)-n-(1-(2,4-dimethylphenyl)ethyl)-2-(6-fluoro-4-...)
Affinity DataKi:  39nM ΔG°:  -39.3kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263487BDBM263487((s)-2-(6-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Affinity DataKi:  42nM ΔG°:  -39.1kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263369BDBM263369((s)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataKi:  48nM ΔG°:  -38.8kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263453BDBM263453((s)-2-(6-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataKi:  58nM ΔG°:  -38.4kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263420BDBM263420((s)-n-(1-(2,4-dimethylphenyl)ethyl)-2-(4-oxobenzo[...)
Affinity DataKi:  63nM ΔG°:  -38.2kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263459BDBM263459((s)-2-(8-methyl-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Affinity DataKi:  72nM ΔG°:  -37.9kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263486BDBM263486((s)-n-(1-(2-fluoro-4-methylphenyl)ethyl)-2-(6-fluo...)
Affinity DataKi:  77nM ΔG°:  -37.7kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263482BDBM263482((s)-2-(8-fluoro-6-methyl-4-oxobenzo[d][1,2,3]triaz...)
Affinity DataKi:  85nM ΔG°:  -37.5kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263474BDBM263474((s)-2-(5-methyl-4-oxobenzo[d][1,2,3]triazin-3 (4h)...)
Affinity DataKi:  92nM ΔG°:  -37.3kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263503BDBM263503((s)-n-(1-(2-fluoro-4-(trifluoromethoxy)phenyl)ethy...)
Affinity DataKi:  93nM ΔG°:  -37.3kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263496BDBM263496((s)-2-(6-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Affinity DataKi:  106nM ΔG°:  -37.0kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263457BDBM263457((s)-2-(8-chloro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Affinity DataKi:  110nM ΔG°:  -36.9kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263492BDBM263492((s)-2-(6-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataKi:  115nM ΔG°:  -36.8kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263509BDBM263509(n-(2-chloro-4-methoxyphenethyl)-2-(4-oxobenzo[d][1...)
Affinity DataKi:  117nM ΔG°:  -36.8kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263368BDBM263368((s)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-...)
Affinity DataKi:  119nM ΔG°:  -36.7kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263502BDBM263502((s)-n-(1-(2-fluoro-4-(trifluoromethoxy)phenyl)ethy...)
Affinity DataKi:  120nM ΔG°:  -36.7kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263501BDBM263501((s)-n-(1-(4-(difluoromethoxy)phenyl)ethyl)-2-(5-me...)
Affinity DataKi:  120nM ΔG°:  -36.7kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263489BDBM263489((s)-2-(6-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataKi:  128nM ΔG°:  -36.6kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263440BDBM263440((s)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-...)
Affinity DataKi:  148nM ΔG°:  -36.2kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263497BDBM263497((s)-n-(1-(2-fluoro-4-(trifluoromethyl)phenyl)ethyl...)
Affinity DataKi:  152nM ΔG°:  -36.2kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263485BDBM263485((s)-n-(1-(2-fluoro-4-methylphenyl)ethyl)-2-(4-oxob...)
Affinity DataKi:  171nM ΔG°:  -35.9kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263456BDBM263456((s)-2-(7-chloro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Affinity DataKi:  173nM ΔG°:  -35.9kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263463BDBM263463((s)-2-(6-methyl-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Affinity DataKi:  179nM ΔG°:  -35.8kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263479BDBM263479((s)-2-(6,8-dimethyl-4-oxobenzo[d][1,2,3]triazin-3(...)
Affinity DataKi:  179nM ΔG°:  -35.8kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263445BDBM263445((s)-2-(6-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Affinity DataKi:  182nM ΔG°:  -35.8kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263511BDBM263511((s)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-...)
Affinity DataKi:  183nM ΔG°:  -35.7kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263454BDBM263454((s)-2-(6-chloro-4-oxobenzo[d][1,2,3]triazin-3 (4h)...)
Affinity DataKi:  189nM ΔG°:  -35.7kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263462BDBM263462((s)-2-(6,8-dichloro-4-oxobenzo[d][1,2,3]triazin-3(...)
Affinity DataKi:  190nM ΔG°:  -35.7kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263512BDBM263512((s)-2-(4-oxobenzo[d][1,2,3]triazin-3 (4h)-yl)-n-(1...)
Affinity DataKi:  214nM ΔG°:  -35.4kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263488BDBM263488((s)-2-(7-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataKi:  218nM ΔG°:  -35.3kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263391BDBM263391((s)-n-(1-(4-chlorophenyl)ethyl)-2-(4-oxobenzo[d][1...)
Affinity DataKi:  228nM ΔG°:  -35.2kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263494BDBM263494((s)-2-(8-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataKi:  240nM ΔG°:  -35.1kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263500BDBM263500((s)-n-(1-(4-(difluoromethoxy)phenyl)ethyl)-2-(6-fl...)
Affinity DataKi:  282nM ΔG°:  -34.8kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263469BDBM263469((s)-2-(7-methyl-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Affinity DataKi:  347nM ΔG°:  -34.3kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263495BDBM263495((s)-2-(8-methoxy-4-oxobenzo[d][1,2,3]triazin-3 (4h...)
Affinity DataKi:  352nM ΔG°:  -34.2kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263491BDBM263491((s)-2-(7-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataKi:  375nM ΔG°:  -34.1kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263480BDBM263480((s)-2-(4-oxo-6-(trifluoromethyl)benzo[d][1,2,3]tri...)
Affinity DataKi:  435nM ΔG°:  -33.8kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263471BDBM263471((s)-2-(7-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataKi:  437nM ΔG°:  -33.7kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263467BDBM263467((s)-2-(5-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Affinity DataKi:  459nM ΔG°:  -33.6kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263370BDBM263370((s)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-...)
Affinity DataKi:  467nM ΔG°:  -33.6kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263460BDBM263460((s)-n-(1-(4-methoxyphenyl)ethyl)-2-(8-methyl-4-oxo...)
Affinity DataKi:  526nM ΔG°:  -33.3kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263477BDBM263477((s)-n-(1-(4-methoxyphenyl)ethyl)-2-(5-methyl-4-oxo...)
Affinity DataKi:  533nM ΔG°:  -33.3kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263455BDBM263455((s)-2-(6-chloro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Affinity DataKi:  551nM ΔG°:  -33.2kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 263473BDBM263473((s)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3 (4h...)
Affinity DataKi:  619nM ΔG°:  -32.9kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

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