BDBM263486 (s)?n-(1-(2-fluoro-4-methylphenyl)ethyl)-2-(6-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)acetamide::US10561662, Example 54::US11173161, EX 54::US9556130, test 54

SMILES C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(C)cc1F

InChI Key InChIKey=DBALUIBYEMXWRA-NSHDSACASA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 263486   

TargetProbable G-protein coupled receptor 139(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM263486((s)?n-(1-(2-fluoro-4-methylphenyl)ethyl)-2-(6-fluo...)
Affinity DataKi:  77nM ΔG°:  -9.01kcal/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProbable G-protein coupled receptor 139(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM263486((s)?n-(1-(2-fluoro-4-methylphenyl)ethyl)-2-(6-fluo...)
Affinity DataKi:  77nMAssay Description:Membranes were removed from −80° C., thawed and diluted in cold radioligand assay buffer (20 mM HEPES pH 7.4/5 mM MgCl2/1 mM CaCl2/Roche protea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProbable G-protein coupled receptor 139(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM263486((s)?n-(1-(2-fluoro-4-methylphenyl)ethyl)-2-(6-fluo...)
Affinity DataKi:  7.70E+4nMAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent