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Found 30 Enz. Inhib. hit(s) with all data for entry = 11047
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588041(9-bromo-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin...)
Affinity DataIC50:  0.350nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588031(9-chloro-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridi...)
Affinity DataIC50:  0.360nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588042(6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)me...)
Affinity DataIC50:  0.590nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588032(9-chloro-2-(4- (dimethylamino)bicyclo[2.2.2]octan-...)
Affinity DataIC50:  1.20nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588043((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  1.21nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588052((2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl...)
Affinity DataIC50:  1.36nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588046((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  2.20nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM172038(US10155002, Compound 44 | US10647700, Compound EPZ...)
Affinity DataIC50:  2.45nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588044((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  2.5nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588050((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  2.70nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588048((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  3.30nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588047((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  3.30nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588045((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  3.40nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588049((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  3.80nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588043((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  8.31nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588042(6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)me...)
Affinity DataIC50:  12nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588044((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  12nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588047((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  14nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588041(9-bromo-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin...)
Affinity DataIC50:  15nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588033(9-chloro-2-(4- (dimethylamino)bicyclo[2.2.2]octan-...)
Affinity DataIC50:  15nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588031(9-chloro-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridi...)
Affinity DataIC50:  15nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588032(9-chloro-2-(4- (dimethylamino)bicyclo[2.2.2]octan-...)
Affinity DataIC50:  17nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588050((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  18nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588048((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  20nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588049((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  22nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588046((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  22nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588052((2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl...)
Affinity DataIC50:  31.5nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588045((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  32nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM172038(US10155002, Compound 44 | US10647700, Compound EPZ...)
Affinity DataIC50:  140nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588033(9-chloro-2-(4- (dimethylamino)bicyclo[2.2.2]octan-...)
Affinity DataIC50:  167nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent