BDBM588045 (R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)methyl)-2- (trans-4- (dimethylamino)cyclohexyl)-2,4- dimethyl-9-(pyridin-4-yl)-7,8- dihydro-[1,3]dioxolo[4,5- g]isoquinolin-5(6H)-one::US11535629, Compound 34

SMILES CN(C)[C@H]1CC[C@@H](CC1)[C@]1(C)Oc2c(O1)c(-c1ccncc1)c1CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c1c2C

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 588045   

TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588045((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  3.40nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588045((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  32nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent