Compile Data Set for Download or QSAR
Report error Found 1162 Enz. Inhib. hit(s) with all data for entry = 1393
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284360BDBM284360(US10023570, Example 370 | 4-(6-(4-(5-cyclopropyl- ...)
Affinity DataIC50: 2.5nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284117BDBM284117(US10023570, Example 127 | US10174027, Example 127)
Affinity DataIC50: 2.70nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284119BDBM284119(US10023570, Example 129 | N-benzyl-4-(5-(3-cyano-6...)
Affinity DataIC50: 2.90nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 283931BDBM283931(US10023570, Example 4 | US10174027, Example 4)
Affinity DataIC50: 3.10nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284552BDBM284552(US10023570, Example 567 | US10174027, Example 567)
Affinity DataIC50: 3.10nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284088BDBM284088(US10023570, Example 98 | 4-(5-(3-cyano-6-(1-methyl...)
Affinity DataIC50: 3.60nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 283981BDBM283981(US10023570, Example 8 | (S)-4-(6-(4-(3- hydroxy-3-...)
Affinity DataIC50: 3.60nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284013BDBM284013(US10023570, Example 23 | US10174027, Example 23)
Affinity DataIC50: 3.80nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284350BDBM284350(US10023570, Example 360 | 4-(6-(4-(2-(5- fluoropyr...)
Affinity DataIC50: 3.90nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 283980BDBM283980(US10023570, Example 7 | (R)-4-(6-(4-(3- hydroxy-3-...)
Affinity DataIC50: 3.90nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284355BDBM284355(US10023570, Example 365 | 4-(6-(4-(2-(4- cyanophen...)
Affinity DataIC50: 4nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284226BDBM284226(US10023570, Example 236 | 1-(5-(3-cyano-6-(1- meth...)
Affinity DataIC50: 4nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284705BDBM284705(US10023570, Example 740 | US10174027, Example 740)
Affinity DataIC50: 4nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284174BDBM284174(US10023570, Example 184 | US10174028, Example 184)
Affinity DataIC50: 4nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284041BDBM284041(US10023570, Example 51 | 4-(6-(4-(2,6- difluoroben...)
Affinity DataIC50: 4.10nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284555BDBM284555(US10023570, Example 570 | US10174027, Example 570)
Affinity DataIC50: 4.20nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284123BDBM284123(US10023570, Example 133 | 4-(5-(3-cyano-6-(1-methy...)
Affinity DataIC50: 4.30nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 283987BDBM283987(US10023570, Example 14 | (R)-6-(1-methyl-1H- pyraz...)
Affinity DataIC50: 4.40nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284059BDBM284059(US10023570, Example 69 | 4-(6-(4-benzoylpiperazin-...)
Affinity DataIC50: 4.40nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284043BDBM284043(US10023570, Example 53 | US10174027, Example 53)
Affinity DataIC50: 4.40nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284548BDBM284548(US10023570, Example 563 | US10174027, Example 563)
Affinity DataIC50: 4.40nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284472BDBM284472(US10023570, Example 482 | US10174027, Example 482)
Affinity DataIC50: 4.40nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284068BDBM284068(US10023570, Example 78 | 6-(1-methyl-1H-pyrazol-4-...)
Affinity DataIC50: 4.40nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284232BDBM284232(US10023570, Example 242 | US10174027, Example 242)
Affinity DataIC50: 4.5nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284476BDBM284476(US10023570, Example 489 | US10174027, Example 489)
Affinity DataIC50: 4.5nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284464BDBM284464(US10023570, Example 474 | US10174027, Example 474)
Affinity DataIC50: 4.5nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 283983BDBM283983(US10023570, Example 10 | 4-(6-(4-(2-(2- fluorophen...)
Affinity DataIC50: 4.5nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284129BDBM284129(US10023570, Example 139 | US10174027, Example 139)
Affinity DataIC50: 4.5nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 283978BDBM283978(US10023570, Example 5 | 6-(1-methyl-1H- pyrazol-4-...)
Affinity DataIC50: 4.60nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284431BDBM284431(US10023570, Example 441 | 4-(6-(4-(2,6- difluorobe...)
Affinity DataIC50: 4.70nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284072BDBM284072(US10023570, Example 82 | US10174027, Example 82)
Affinity DataIC50: 4.80nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284629BDBM284629(US10023570, Example 664 | US10174027, Example 664)
Affinity DataIC50: 4.90nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 283979BDBM283979(US10023570, Example 6 | (S)-4-(6-(4-(2- hydroxy-2-...)
Affinity DataIC50: 4.90nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284441BDBM284441(US10023570, Example 451 | 4-(6-(4-(2- methoxybenzy...)
Affinity DataIC50: 4.90nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284015BDBM284015(US10023570, Example 25 | 6-(1-methyl-1H-pyrazol-4-...)
Affinity DataIC50: 5nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284348BDBM284348(US10023570, Example 358 | 6-(1-methyl-1H-pyrazol- ...)
Affinity DataIC50: 5.10nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284526BDBM284526(US10023570, Example 540 | 4-(6-(2,9- diazaspiro[5....)
Affinity DataIC50: 5.10nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284189BDBM284189(US10023570, Example 199 | US10174028, Example 199)
Affinity DataIC50: 5.10nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284527BDBM284527(US10023570, Example 541 | 4-(6-(1,8- diazaspiro[4....)
Affinity DataIC50: 5.20nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284567BDBM284567(US10023570, Example 586 | US10174027, Example 586)
Affinity DataIC50: 5.20nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284080BDBM284080(US10023570, Example 90 | 4-(6-(4- (isobutylsulfony...)
Affinity DataIC50: 5.20nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284077BDBM284077(BDBM320540 | US10023570, Example 87)
Affinity DataIC50: 5.30nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 283982BDBM283982(US10023570, Example 9 | (R)-4-(6-(4-(2- hydroxy-3-...)
Affinity DataIC50: 5.30nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284379BDBM284379(US10023570, Example 389 | 4-(6-(4-(3- ethylpyrroli...)
Affinity DataIC50: 5.40nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284128BDBM284128(US10023570, Example 138 | US10174027, Example 138)
Affinity DataIC50: 5.40nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284124BDBM284124(US10023570, Example 134 | 4-(5-(3-cyano-6-(1-methy...)
Affinity DataIC50: 5.5nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284374BDBM284374(US10023570, Example 384 | 4-(6-(4-(6,6-dimethyl- 3...)
Affinity DataIC50: 5.5nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284051BDBM284051(US10023570, Example 61 | (S)-6-(1-methyl-1H-pyrazo...)
Affinity DataIC50: 5.5nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284440BDBM284440(US10023570, Example 450 | 4-(6-(4-(3- methoxybenzy...)
Affinity DataIC50: 5.5nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284233BDBM284233(US10023570, Example 243 | US10174027, Example 243)
Affinity DataIC50: 5.60nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

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