Compile Data Set for Download or QSAR
Report error Found 65 Enz. Inhib. hit(s) with all data for entry = 9248
TargetTyrosine-protein kinase Blk(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.580nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452965(US10711006, Compound 15a | US10711006, Compound 17...)
Affinity DataIC50: 1.20nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452981(US10711006, Compound 17i | US10711006, Compound 18)
Affinity DataIC50: 1.20nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Blk(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452963(US10711006, Compound I)
Affinity DataIC50: 1.60nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452990(US10711006, Compound 24e)
Affinity DataIC50: 1.80nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 2.10nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452963(US10711006, Compound I)
Affinity DataIC50: 2.20nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452966(US10711006, Compound 15b)
Affinity DataIC50: 2.5nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452974(US10711006, Compound 15j)
Affinity DataIC50: 3.20nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452964(US10711006, Compound II)
Affinity DataIC50: 3.20nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452986(US10711006, Compound 23b)
Affinity DataIC50: 4.40nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452984(US10711006, Compound 20a)
Affinity DataIC50: 5.30nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Blk(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452966(US10711006, Compound 15b)
Affinity DataIC50: 5.40nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452975(US10711006, Compound 15k)
Affinity DataIC50: 6.5nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452965(US10711006, Compound 15a | US10711006, Compound 17...)
Affinity DataIC50: 6.60nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452981(US10711006, Compound 17i | US10711006, Compound 18)
Affinity DataIC50: 7.20nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452989(US10711006, Compound 24a)
Affinity DataIC50: 7.40nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452970(US10711006, Compound 15f)
Affinity DataIC50: 7.5nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452973(US10711006, Compound 15i)
Affinity DataIC50: 7.80nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 8nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452969(US10711006, Compound 15e)
Affinity DataIC50: 8.60nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452979(US10711006, Compound 16d)
Affinity DataIC50: 8.60nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452978(US10711006, Compound 16c)
Affinity DataIC50: 8.90nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452968(US10711006, Compound 15d)
Affinity DataIC50: 9.5nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452987(US10711006, Compound 23c)
Affinity DataIC50: 9.60nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452988(US10711006, Compound 23d)
Affinity DataIC50: 9.70nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452983(US10711006, Compound 19)
Affinity DataIC50: 10.3nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452971(US10711006, Compound 15g)
Affinity DataIC50: 10.5nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Blk(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452965(US10711006, Compound 15a | US10711006, Compound 17...)
Affinity DataIC50: 11nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452967(US10711006, Compound 15c)
Affinity DataIC50: 14nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452977(US10711006, Compound 16b)
Affinity DataIC50: 18.2nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452985(US10711006, Compound 23a)
Affinity DataIC50: 18.6nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452991(US10711006, Compound 25a)
Affinity DataIC50: 25.1nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452972(US10711006, Compound 15h)
Affinity DataIC50: 25.3nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452963(US10711006, Compound I)
Affinity DataIC50: 27nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Blk(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452964(US10711006, Compound II)
Affinity DataIC50: 30nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452976(US10711006, Compound 16a)
Affinity DataIC50: 32.5nMAssay Description:The drug was dissolved in DMSO to make a 10 mM (mmol/L) stock solution, and the stock solution was then diluted to a drug solution with 50× test conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase CSK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 37nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 105nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase HCK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 179nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase CSK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452963(US10711006, Compound I)
Affinity DataIC50: 180nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 186nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 231nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452963(US10711006, Compound I)
Affinity DataIC50: 350nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452963(US10711006, Compound I)
Affinity DataIC50: 428nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452963(US10711006, Compound I)
Affinity DataIC50: 901nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase CSK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452966(US10711006, Compound 15b)
Affinity DataIC50: 1.00E+3nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452965(US10711006, Compound 15a | US10711006, Compound 17...)
Affinity DataIC50: 1.00E+3nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452966(US10711006, Compound 15b)
Affinity DataIC50: 1.00E+3nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase HCK(Human)
Hangzhou Hertz Pharmaceutical

US Patent
LigandPNGBDBM452965(US10711006, Compound 15a | US10711006, Compound 17...)
Affinity DataIC50: 1.00E+3nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

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