Compile Data Set for Download or QSAR
Report error Found 168 Enz. Inhib. hit(s) with all data for entry = 6923
TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159770BDBM159770(US9035074, 21 | US10966980, Example 21)
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159756BDBM159756(PF-02384554 | US9035074, 8 | US10966980, Example 8)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159769BDBM159769(US9035074, 20 | US10966980, Example 20)
Affinity DataIC50: 4nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159786BDBM159786(US9035074, 36 | US10966980, Example 36)
Affinity DataIC50: 4nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159788BDBM159788(US9035074, 38 | US10966980, Example 38)
Affinity DataIC50: 4.60nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159765BDBM159765(US9035074, 17A | US10966980, Example 17A)
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159782BDBM159782(US9035074, 33 | US10966980, Example 33)
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159761BDBM159761(US9035074, 13 | US10966980, Example 13)
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159777BDBM159777(US9035074, 28 | US10966980, Example 28)
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159750BDBM159750(US9035074, 4B | US10966980, Example 4B)
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159760BDBM159760(US9035074, 12 | US10966980, Example 12)
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159776BDBM159776(US9035074, 26 | US10966980, Example 26)
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159763BDBM159763(US9035074, 15 | US10966980, Example 15)
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159752BDBM159752(US9035074, 5 | US10966980, Example 5)
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159787BDBM159787(US9035074, 37 | US10966980, Example 37)
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159772BDBM159772(US9035074, 23 | US10966980, Example 23)
Affinity DataIC50: 8nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159783BDBM159783(US9035074, 34B | US10966980, Example 34B)
Affinity DataIC50: 9nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159779BDBM159779(US9035074, 30 | US10966980, Example 30)
Affinity DataIC50: 9nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159775BDBM159775(US9035074, 25 | US10966980, Example 25)
Affinity DataIC50: 9nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159766BDBM159766(US9035074, 17B | US10966980, Example 17B)
Affinity DataIC50: 13nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159749BDBM159749(US9035074, 3 | US10966980, Example 3)
Affinity DataIC50: 14nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159781BDBM159781(US9035074, 32 | US10966980, Example 32)
Affinity DataIC50: 14nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159755BDBM159755(US9035074, 7B | US10966980, Example 7B)
Affinity DataIC50: 16nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159778BDBM159778(US9035074, 29 | US10966980, Example 29)
Affinity DataIC50: 17nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159773BDBM159773(US9035074, 27 | US10966980, Example 27)
Affinity DataIC50: 17nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159751BDBM159751(US9035074, 4A | US10966980, Example 4A)
Affinity DataIC50: 18nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159747BDBM159747(US9035074, 1 | US10966980, Example 1)
Affinity DataIC50: 22nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159771BDBM159771(US9035074, 22 | US10966980, Example 22)
Affinity DataIC50: 22nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159753BDBM159753(US9035074, 6 | US10966980, Example 6)
Affinity DataIC50: 28nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159748BDBM159748(US9035074, 2 | US10966980, Example 2)
Affinity DataIC50: 29nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159759BDBM159759(US9035074, 11)
Affinity DataIC50: 29nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159754BDBM159754(US9035074, 7A | US10966980, Example 7A)
Affinity DataIC50: 31nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159768BDBM159768(US9035074, 19 | US10966980, Example 19)
Affinity DataIC50: 34nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159784BDBM159784(US9035074, 34A | US10966980, Example 135)
Affinity DataIC50: 37nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159762BDBM159762(US9035074, 14 | US10966980, Example 14)
Affinity DataIC50: 42nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159767BDBM159767(US9035074, 18 | US10966980, Example 18)
Affinity DataIC50: 46nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159764BDBM159764(US9035074, 16 | US10966980, Example 16)
Affinity DataIC50: 51nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159770BDBM159770(US9035074, 21 | US10966980, Example 21)
Affinity DataIC50: 52nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159780BDBM159780(US9035074, 31 | US10966980, Example 31)
Affinity DataIC50: 67nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159786BDBM159786(US9035074, 36 | US10966980, Example 36)
Affinity DataIC50: 85nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159776BDBM159776(US9035074, 26 | US10966980, Example 26)
Affinity DataIC50: 88nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159785BDBM159785(US9035074, 35 | US10966980, Example 35)
Affinity DataIC50: 106nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159782BDBM159782(US9035074, 33 | US10966980, Example 33)
Affinity DataIC50: 161nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159769BDBM159769(US9035074, 20 | US10966980, Example 20)
Affinity DataIC50: 171nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159761BDBM159761(US9035074, 13 | US10966980, Example 13)
Affinity DataIC50: 177nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159777BDBM159777(US9035074, 28 | US10966980, Example 28)
Affinity DataIC50: 179nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159779BDBM159779(US9035074, 30 | US10966980, Example 30)
Affinity DataIC50: 220nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159757BDBM159757(US9035074, 9 | US10966980, Example 9)
Affinity DataIC50: 231nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159774BDBM159774(US9035074, 24 | US10966980, Example 24)
Affinity DataIC50: 241nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 159786BDBM159786(US9035074, 36 | US10966980, Example 36)
Affinity DataIC50: 242nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

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