Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 6866
TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155133BDBM155133(US9000184, 6, isomer 1)
Affinity DataIC50: 1nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155138BDBM155138(US9000184, 8, isomer 2)
Affinity DataIC50: 2.40nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155135BDBM155135(US9000184, 7, isomer 1)
Affinity DataIC50: 2.5nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155140BDBM155140(US9000184, 10, isomer 1)
Affinity DataIC50: 3.10nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155142BDBM155142(US9000184, 11, isomer 1)
Affinity DataIC50: 3.60nMpH: 2.5Assay Description:TR-FRET Assay: The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human beta -Secretase (AA 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155142BDBM155142(US9000184, 11, isomer 1)
Affinity DataIC50: 4.5nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155133BDBM155133(US9000184, 6, isomer 1)
Affinity DataIC50: 5nMpH: 2.5Assay Description:TR-FRET Assay: The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human beta -Secretase (AA 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155140BDBM155140(US9000184, 10, isomer 1)
Affinity DataIC50: 5.70nMpH: 2.5Assay Description:TR-FRET Assay: The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human beta -Secretase (AA 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155130BDBM155130(US9000184, 4)
Affinity DataIC50: 11nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155135BDBM155135(US9000184, 7, isomer 1)
Affinity DataIC50: 14nMpH: 2.5Assay Description:TR-FRET Assay: The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human beta -Secretase (AA 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155139BDBM155139(US9000184, 9)
Affinity DataIC50: 15nMpH: 2.5Assay Description:TR-FRET Assay: The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human beta -Secretase (AA 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155139BDBM155139(US9000184, 9)
Affinity DataIC50: 16nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155136BDBM155136(US9000184, 7, isomer 2)
Affinity DataIC50: 19nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155138BDBM155138(US9000184, 8, isomer 2)
Affinity DataIC50: 19nMpH: 2.5Assay Description:The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human beta -Secretase (AA 1-AA 460) was cl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155128BDBM155128(US9000184, 2)
Affinity DataIC50: 23nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155130BDBM155130(US9000184, 4)
Affinity DataIC50: 30nMpH: 2.5Assay Description:TR-FRET Assay: The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human beta -Secretase (AA 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155131BDBM155131(US9000184, 5, isomer 1)
Affinity DataIC50: 78nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155128BDBM155128(US9000184, 2)
Affinity DataIC50: 79nMpH: 2.5Assay Description:The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human beta -Secretase (AA 1-AA 460) was cl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155134BDBM155134(US9000184, 6, isomer 2)
Affinity DataIC50: 80nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155137BDBM155137(US9000184, 8, isomer 1)
Affinity DataIC50: 81nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155141BDBM155141(US9000184, 10, isomer 2)
Affinity DataIC50: 92nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155129BDBM155129(US9000184, 3)
Affinity DataIC50: 118nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155129BDBM155129(US9000184, 3)
Affinity DataIC50: 130nMpH: 2.5Assay Description:The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human beta -Secretase (AA 1-AA 460) was cl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155137BDBM155137(US9000184, 8, isomer 1)
Affinity DataIC50: 212nMpH: 2.5Assay Description:The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human beta -Secretase (AA 1-AA 460) was cl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155136BDBM155136(US9000184, 7, isomer 2)
Affinity DataIC50: 333nMpH: 2.5Assay Description:The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human beta -Secretase (AA 1-AA 460) was cl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155141BDBM155141(US9000184, 10, isomer 2)
Affinity DataIC50: 392nMpH: 2.5Assay Description:The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human beta -Secretase (AA 1-AA 460) was cl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155131BDBM155131(US9000184, 5, isomer 1)
Affinity DataIC50: 411nMpH: 2.5Assay Description:The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human beta -Secretase (AA 1-AA 460) was cl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155134BDBM155134(US9000184, 6, isomer 2)
Affinity DataIC50: 587nMpH: 2.5Assay Description:The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human beta -Secretase (AA 1-AA 460) was cl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155127BDBM155127(US9000184, 1)
Affinity DataIC50: 4.87E+3nMpH: 2.5Assay Description:The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human beta -Secretase (AA 1-AA 460) was cl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155143BDBM155143(US9000184, 11, isomer 2)
Affinity DataIC50: 5.00E+3nMpH: 2.5Assay Description:The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human beta -Secretase (AA 1-AA 460) was cl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 155132BDBM155132(US9000184, 5, isomer 2)
Affinity DataIC50: 8.92E+3nMpH: 2.5Assay Description:The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human beta -Secretase (AA 1-AA 460) was cl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent