Compile Data Set for Download or QSAR
Report error Found 1149 Enz. Inhib. hit(s) with all data for entry = 8977
TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337913BDBM50337913(N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)etha...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337830BDBM50337830(N-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)-N-met...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337912BDBM50337912(N-methyl-1-(1-(naphthalen-2-yl)cyclohexyl)ethanami...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 433711BDBM433711(US10562878, Compound 269 | US10562878, Compound 26...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337844BDBM50337844(1-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)-4-met...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 433734BDBM433734(US10562878, Compound 206 E2 | US10562878, Compound...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337831BDBM50337831(N,N-dimethyl-1-(1-(naphthalen-1-yl)cyclohexyl)meth...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337831BDBM50337831(N,N-dimethyl-1-(1-(naphthalen-1-yl)cyclohexyl)meth...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 433654BDBM433654(US10562878, Compound 115)
Affinity DataIC50: 1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337829BDBM50337829(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dimethylm...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 433673BDBM433673(US10562878, Compound 261 | US10562878, Compound 25...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337915BDBM50337915((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-3-methy...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337818BDBM50337818(N-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)-N-eth...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 433905BDBM433905(US10562878, Compound 162 E1 | US10562878, Compound...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50149940BDBM50149940(CHEMBL3770651 | US10562878, Compound 203)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337823BDBM50337823(1-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)pyrrol...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 433675BDBM433675(US10562878, Compound 72)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 433842BDBM433842(US10562878, Compound 63 E1 | US10562878, Compound ...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50149940BDBM50149940(CHEMBL3770651 | US10562878, Compound 203)
Affinity DataIC50: 2nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 433736BDBM433736(US10562878, Compound 163 E2 | US10562878, Compound...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337832BDBM50337832(N-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)cyclop...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337822BDBM50337822(4-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)morpho...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetNeuroepithelial cell-transforming 1(Rat)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337910BDBM50337910(CHEMBL1684057 | 1-(1-(3,4-dichlorophenyl)cyclohexy...)
Affinity DataIC50: 2.20nMAssay Description:Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetNeuroepithelial cell-transforming 1(Rat)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337912BDBM50337912(N-methyl-1-(1-(naphthalen-2-yl)cyclohexyl)ethanami...)
Affinity DataIC50: 2.30nMAssay Description:Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetNeuroepithelial cell-transforming 1(Rat)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 433673BDBM433673(US10562878, Compound 261 | US10562878, Compound 25...)
Affinity DataIC50: 2.40nMAssay Description:Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetNeuroepithelial cell-transforming 1(Rat)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 433764BDBM433764(US10562878, Compound 276 | US10562878, Compound 27...)
Affinity DataIC50: 2.70nMAssay Description:Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Rat)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337912BDBM50337912(N-methyl-1-(1-(naphthalen-2-yl)cyclohexyl)ethanami...)
Affinity DataIC50: 2.90nMAssay Description:Quantification of 5-HT uptake was performed using synaptosomes isolated in a 0.32M sucrose buffer from a male Wistar rat cortex. The uptake of radiol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetNeuroepithelial cell-transforming 1(Rat)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337831BDBM50337831(N,N-dimethyl-1-(1-(naphthalen-1-yl)cyclohexyl)meth...)
Affinity DataIC50: 2.90nMAssay Description:Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 433652BDBM433652(US10562878, Compound 116)
Affinity DataIC50: 3nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 433835BDBM433835(US10562878, Compound 235 | US10562878, Compound 23...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337833BDBM50337833(N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)meth...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337833BDBM50337833(N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexyl)meth...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50149940BDBM50149940(CHEMBL3770651 | US10562878, Compound 203)
Affinity DataIC50: 3nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetNeuroepithelial cell-transforming 1(Rat)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337912BDBM50337912(N-methyl-1-(1-(naphthalen-2-yl)cyclohexyl)ethanami...)
Affinity DataIC50: 3.60nMAssay Description:Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337834BDBM50337834(N-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)ethana...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 433566BDBM433566(US10562878, Compound 172 E2 | US10562878, Compound...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 433833BDBM433833(US10562878, Compound 293)
Affinity DataIC50: 4nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337829BDBM50337829(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dimethylm...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 433836BDBM433836(US10562878, Compound 62 E2 | US10562878, Compound ...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337914BDBM50337914((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)propan-1...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 433911BDBM433911(US10562878, Compound 252)
Affinity DataIC50: 5nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetNeuroepithelial cell-transforming 1(Rat)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337910BDBM50337910(CHEMBL1684057 | 1-(1-(3,4-dichlorophenyl)cyclohexy...)
Affinity DataIC50: 5.10nMAssay Description:Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 433911BDBM433911(US10562878, Compound 252)
Affinity DataIC50: 6nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337912BDBM50337912(N-methyl-1-(1-(naphthalen-2-yl)cyclohexyl)ethanami...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetNeuroepithelial cell-transforming 1(Rat)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337829BDBM50337829(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dimethylm...)
Affinity DataIC50: 6nMAssay Description:Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Rat)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337818BDBM50337818(N-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)-N-eth...)
Affinity DataIC50: 6nMAssay Description:Quantification of dopamine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat striatum. The uptake of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337818BDBM50337818(N-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)-N-eth...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 433715BDBM433715(US10562878, Compound trans 125 E1 | US10562878, Co...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Rat)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337831BDBM50337831(N,N-dimethyl-1-(1-(naphthalen-1-yl)cyclohexyl)meth...)
Affinity DataIC50: 6.10nMAssay Description:Quantification of dopamine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat striatum. The uptake of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Rat)
Sunovion Pharamceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50337831BDBM50337831(N,N-dimethyl-1-(1-(naphthalen-1-yl)cyclohexyl)meth...)
Affinity DataIC50: 6.5nMAssay Description:Quantification of 5-HT uptake was performed using synaptosomes isolated in a 0.32M sucrose buffer from a male Wistar rat cortex. The uptake of radiol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

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