Compile Data Set for Download or QSAR
Report error Found 202 Enz. Inhib. hit(s) with all data for entry = 10084
TargetIntegrin alpha-5(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 10484BDBM10484(US8846719, 301 | US11091471, Example RO-301 | US20...)
Affinity DataKi:  0.200nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetIntegrin alpha-5(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513334BDBM513334(US11091471, Example RE-B | US20240279218, Example ...)
Affinity DataKi:  0.400nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513240BDBM513240(6-((5-methyl-3-(6-methylpyridazin-3-yl)isoxazol-4-...)
Affinity DataKi:  0.400nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513241BDBM513241(N-((1S)-1-(hydroxymethyl)butyl)-6-((5-methyl-3-(6-...)
Affinity DataKi:  0.800nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetIntegrin alpha-5(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 133559BDBM133559(US8846719, 251 | US11091471, Example RO-251 | US20...)
Affinity DataKi:  1nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetIntegrin alpha-5(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 133580BDBM133580(US8846719, 272 | US11091471, Example RO-272 | US20...)
Affinity DataKi:  1nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513325BDBM513325(6-((5-methyl-3-(6-methylpyridazin-3-yl)isoxazol-4-...)
Affinity DataKi:  1nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513187BDBM513187(5-methyl-6-((5-methyl-3-(6-methylpyridin-3-yl)isox...)
Affinity DataKi:  1.20nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513040BDBM513040(N-ethyl-6-((5-methyl-3-(6-methyl-3-pyridyl)isoxazo...)
Affinity DataKi:  1.40nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513191BDBM513191(5-methyl-6-((5-methyl-3-(6-methylpyridin-3-yl)isox...)
Affinity DataKi:  2.40nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513297BDBM513297(6-((5-cyclopropyl-3-(6-methylpyridazin-3-yl)isoxaz...)
Affinity DataKi:  2.60nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetIntegrin alpha-5(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513332BDBM513332(US11091471, Example RO-094 | US20240279218, Exampl...)
Affinity DataKi:  2.90nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513324BDBM513324(6-((5-(fluoromethyl)-3-(6-methylpyridazin-3-yl)iso...)
Affinity DataKi:  3nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513146BDBM513146(N-methyl-6-((5-methyl-3-(6-methylpyridin-3-yl)isox...)
Affinity DataKi:  3.5nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513121BDBM513121(6-((5-methyl-3-(6-methylpyridin-3-yl)isoxazol-4-yl...)
Affinity DataKi:  4.40nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513175BDBM513175((6-((5-methyl-3-(6-methylpyridin-3-yl)isoxazol-4-y...)
Affinity DataKi:  4.60nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513243BDBM513243(N-(4-methyl-1,1-dioxidotetrahydro-2H-thiopyran-4-y...)
Affinity DataKi:  4.60nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513274BDBM513274(4-methoxy-6-((5-methyl-3-(6-methylpyridin-3-yl)iso...)
Affinity DataKi:  4.70nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513032BDBM513032(6-((5-methyl-3-(6-methyl-3-pyridyl)isoxazol-4-yl)m...)
Affinity DataKi:  4.80nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513248BDBM513248(N-(1-isopropylazetidin-3-yl)-6-((5-methyl-3-(6-met...)
Affinity DataKi:  4.90nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513210BDBM513210(6-((5-methyl-3-(6-methylpyridin-3-yl) isoxazol-4-y...)
Affinity DataKi:  5nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513281BDBM513281(N-((1R,3S)-3-hydroxy-3-(trifluoromethyl)cyclopenty...)
Affinity DataKi:  5nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513081BDBM513081(N-((3S)-1,1-dioxothiolan-3-yl)-6-((5-methyl-3-(6-m...)
Affinity DataKi:  5.20nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513103BDBM513103(N-cyclopropyl-6-((5-methyl-3-(6-methylpyridin-3-yl...)
Affinity DataKi:  5.20nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513201BDBM513201(5-((5-methyl-3-(6-methyl-3-pyridyl)isoxazol-4-yl)m...)
Affinity DataKi:  5.20nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513284BDBM513284(N-((1RS,3RS)-3-hydroxycyclopentyl)-6-((5-methyl-3-...)
Affinity DataKi:  5.30nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513088BDBM513088(N-(1,1-dioxothian-4-yl)-6-((5-methyl-3-(6-methylpy...)
Affinity DataKi:  5.40nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513285BDBM513285(trans-N-(4-hydroxycyclohexyl)-6-((5-methyl-3-(6-me...)
Affinity DataKi:  5.5nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513223BDBM513223(2-(1,1-dioxothian-4-yl)-6-((5-methyl-3-(6-methylpy...)
Affinity DataKi:  5.5nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513179BDBM513179((3-hydroxyazetidin-1-yl)(6-((5-methyl-3-(6-methylp...)
Affinity DataKi:  5.80nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513123BDBM513123((RS) N-(1,1-dioxothiolan-3-yl)-6-((5-methyl-3-(6-m...)
Affinity DataKi:  5.80nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513289BDBM513289(3-oxa-6-azabicyclo[3.1.1]heptan-6-yl(6-((5-methyl-...)
Affinity DataKi:  6nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513260BDBM513260(6-((3-(6-cyclopropyl-3-pyridyl)-5-methyl-isoxazol-...)
Affinity DataKi:  6.10nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513225BDBM513225(2-((5-methyl-3-(6-methyl-3-pyridyl)isoxazol-4-yl)m...)
Affinity DataKi:  6.20nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513216BDBM513216(N-(1-(hydroxymethyl)cyclopropyl)-6-((5-methyl-3-(6...)
Affinity DataKi:  6.30nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513244BDBM513244((2,2-dioxido-2-thia-6-azaspiro[3.3]heptan-6-yl)(6-...)
Affinity DataKi:  6.5nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513144BDBM513144((RS)-6-((5-methyl-3-(6-methylpyridin-3-yl)isoxazol...)
Affinity DataKi:  6.60nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513231BDBM513231((R)-6-((5-methyl-3-(6-methylpyridin-3-yl)isoxazol-...)
Affinity DataKi:  6.80nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513170BDBM513170((6-((5-methyl-3-(6-methylpyridin-3-yl)isoxazol-4-y...)
Affinity DataKi:  7.10nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513161BDBM513161(azetidin-1-yl(6-((5-methyl-3-(6-methylpyridin-3-yl...)
Affinity DataKi:  7.20nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513228BDBM513228(2-(4,4-difluorocyclohexyl)-6-((5-methyl-3-(6-methy...)
Affinity DataKi:  7.20nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513178BDBM513178((3-fluoroazetidin-1-yl)(6-((5-methyl-3-(6-methylpy...)
Affinity DataKi:  7.20nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513042BDBM513042((S) N-(1-hydroxypentan-2-yl)-6-((5-methyl-3-(6-met...)
Affinity DataKi:  7.30nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513128BDBM513128(N-isopropyl-6-((5-methyl-3-(6-methylpyridin-3-yl)i...)
Affinity DataKi:  7.5nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513151BDBM513151(6-((5-methyl-3-(6-methyl-3-pyridyl)isoxazol-4-yl)m...)
Affinity DataKi:  7.60nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513127BDBM513127(N-ethyl-6-((5-methyl-3-(6-methylpyridin-3-yl)isoxa...)
Affinity DataKi:  7.60nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513298BDBM513298(trans-N-((1RS,3RS)-3-methoxycyclopentyl)-6-((5-met...)
Affinity DataKi:  7.60nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513183BDBM513183(N-(1-cyanocyclopropyl)-6-((5-methyl-3-(6-methylpyr...)
Affinity DataKi:  7.70nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513288BDBM513288(N-(3-hydroxycyclohexyl)-6-((5-methyl-3-(6-methylpy...)
Affinity DataKi:  7.80nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 513159BDBM513159((3-hydroxy-3-methylazetidin-1-yl)(6-((5-methyl-3-(...)
Affinity DataKi:  7.90nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

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