Compile Data Set for Download or QSAR
Report error Found 344 Enz. Inhib. hit(s) with all data for entry = 11687
TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639724(US20230391786, Example 193 | 3-[[6,7-Dichloro-3-(1...)
Affinity DataIC50: 3.22nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639875((S)—N-(5,6-Dichloro-8-(cyanomethoxy)-9-(1H-py...)
Affinity DataIC50: 3.38nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639703(US20230391786, Example 171 | N-[6, 7-Dichloro-3-(1...)
Affinity DataIC50: 3.56nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639763(US20230391786, Example 232 | (S)—N-(5,6-Dichl...)
Affinity DataIC50: 3.76nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639676(3-[[6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl...)
Affinity DataIC50: 4.33nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639869(3-((6,7-Dichloro-2-(hydroxymethyl)-3-(1H-pyrazol-4...)
Affinity DataIC50: 4.74nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639655(US20230391786, Example 123 | 6,7-Dichloro-N-(2-flu...)
Affinity DataIC50: 4.91nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639685(US20230391786, Example 153 | N-((6,7-Dichloro-4-(c...)
Affinity DataIC50: 5.11nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639781(3-[[6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indazol-4-...)
Affinity DataIC50: 5.20nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639702(US20230391786, Example 170 | N-(6,7-Dichloro-3-(1H...)
Affinity DataIC50: 5.67nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639874((S)—N-(5,6-Dichloro-8-ethoxy-9-(1H-pyrazol-4-...)
Affinity DataIC50: 6.14nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639734(US20230391786, Example 203 | 2-((6,7-Dichloro-2-(5...)
Affinity DataIC50: 6.77nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639879(3,4-Dichloro-1-(3-hydroxypropoxy)-10-(1H-pyrazol-4...)
Affinity DataIC50: 6.95nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639810(2-((6,7-Dichloro-2-(2-methoxyacetyl)-10-(1H-pyrazo...)
Affinity DataIC50: 7.20nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639768(N-(5,6-Dichloro-9-(1H-pyrazol-4-yl)-2,3-dihydro-1H...)
Affinity DataIC50: 7.69nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639870(6,7-Dichloro-9-(3-hydroxypropoxy)-2-methyl-10-(1H-...)
Affinity DataIC50: 7.89nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639811(US20230391786, Example 280)
Affinity DataIC50: 8.70nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639812(US20230391786, Example 281)
Affinity DataIC50: 8.90nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639728(US20230391786, Example 197 | 22-[6, 7-Dichloro-1-[...)
Affinity DataIC50: 8.93nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639813(US20230391786, Example 282)
Affinity DataIC50: 8.96nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639775((S)—N-(2-Acetamido-5,6-dichloro-9-(1H-pyrazol...)
Affinity DataIC50: 9.90nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639871(2-((6,7-Dichloro-2-(hydroxymethyl)-3-(1H-pyrazol-4...)
Affinity DataIC50: 10.2nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639657(US20230391786, Example 125 | 3-((6,7-Dichloro-3-(1...)
Affinity DataIC50: 10.3nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639718(US20230391786, Example 187 | 3-[[6,7-Dichloro-3-(1...)
Affinity DataIC50: 10.4nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639814(US20230391786, Example 283)
Affinity DataIC50: 10.6nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639729(US20230391786, Example 198 | 3-[[6,7-Dichloro-1-[1...)
Affinity DataIC50: 11nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639665(US20230391786, Example 133 | N-[[6,7-Dichloro-1-me...)
Affinity DataIC50: 11.2nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639623(US20230391786, Example 89 | 2-((6,7-Dichloro-2-(2-...)
Affinity DataIC50: 11.2nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639711(5-[6,7-Dichloro-10-(1H-pyrazol-4-yl)-3,4-dihydro-1...)
Affinity DataIC50: 11.5nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639547(US20230391786, Example 13 | 3,4-Dichloro-10-(1H-py...)
Affinity DataIC50: 11.7nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639714(US20230391786, Example 183 | 6,7-Dichloro-4-(2-flu...)
Affinity DataIC50: 11.8nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639756(US20230391786, Example 225 | N-[6,7-Dichloro-2-(2-...)
Affinity DataIC50: 12.1nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639776((S)—N-(5,6-Dichloro-8-(cyanomethoxy)-9-(1H-py...)
Affinity DataIC50: 12.2nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639878(2-((5,6-Dichloro-1-(hydroxymethyl)-9-(1H-pyrazol-4...)
Affinity DataIC50: 12.2nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639868(N-(6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indazol-4-y...)
Affinity DataIC50: 12.4nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639815(US20230391786, Example 284)
Affinity DataIC50: 12.4nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639743(US20230391786, Example 212 | 2-[4-[6,7-Dichloro-3-...)
Affinity DataIC50: 12.5nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639816(US20230391786, Example 285)
Affinity DataIC50: 12.6nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639674(US20230391786, Example 142 | 2-[[6,7-Dichloro-2-(2...)
Affinity DataIC50: 12.7nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639717(US20230391786, Example 186 | 3-[[6,7-Dichloro-3-(1...)
Affinity DataIC50: 12.7nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639663(US20230391786, Example 131 | N-(6,7-Dichloro-2-(hy...)
Affinity DataIC50: 13.1nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639817(US20230391786, Example 286)
Affinity DataIC50: 13.1nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639654(US20230391786, Example 122 | 6, 7-Dichloro-N-(2,2-...)
Affinity DataIC50: 13.7nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639701(US20230391786, Example 169 | N-(6,7-Dichloro-3-(1H...)
Affinity DataIC50: 13.8nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639784(1-[6,7-Dichloro-9-(3-hydroxypropylamino)-10-(1H-py...)
Affinity DataIC50: 14nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639684(US20230391786, Example 152 | 2-[4-[6-Chloro-5-meth...)
Affinity DataIC50: 14.2nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639705(US20230391786, Example 173 | 3-[[6-Chloro-7-fluoro...)
Affinity DataIC50: 14.5nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639686(N-(5,6-Dichloro-9-(1H-pyrazol-4-yl)-2,3-dihydro-1H...)
Affinity DataIC50: 14.6nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639768(N-(5,6-Dichloro-9-(1H-pyrazol-4-yl)-2,3-dihydro-1H...)
Affinity DataIC50: 15nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639596(US20230391786, Example 62 | 2-[[6, 7-Dichloro-3-(1...)
Affinity DataIC50: 15.1nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
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Date in BDB:
1/28/2024
Entry Details
US Patent

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