Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 9284
TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455363(US10730881, Example 26 | 7-(2,3-Difluorophenyl)-N4...)
Affinity DataEC50:  6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455355(US10730881, Example 21 | 2-((7-(4-Fluorophenyl)-2-...)
Affinity DataEC50:  9nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455353(US10730881, Example 19 | 7-(2,4-Difluorophenyl)-N2...)
Affinity DataEC50:  9nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455358(US10730881, Example 24 | 7-(2,3-Difluorophenyl)-N4...)
Affinity DataEC50:  9nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455364(US10730881, Example 27 | 7-(2,3-Difluorophenyl)-N4...)
Affinity DataEC50:  10nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455341(US10730881, Example 7 | N2-((1R,5S,8s)-3-(6-Chloro...)
Affinity DataEC50:  11nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455354(US10730881, Example 20 | 2-((7-(4-Fluorophenyl)-5,...)
Affinity DataEC50:  12nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455336(US10730881, Example 3 | 7-(4-Fluorophenyl)-N2-((1R...)
Affinity DataEC50:  12nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455344(US10730881, Example 10 | 7-(4-Fluorophenyl)-N4-met...)
Affinity DataEC50:  12nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455334(US10730881, Example 1 | 7-(4-Fluorophenyl)-N4,5,5-...)
Affinity DataEC50:  14nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455349(US10730881, Example 15 | 7-(2,4-Difluorophenyl)-N4...)
Affinity DataEC50:  14nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455345(US10730881, Example 11 | 7-(3,4-Difluorophenyl)-N2...)
Affinity DataEC50:  16nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455359(US10730881, Example 25p | (S)- or (R)-7-(4-Fluorop...)
Affinity DataEC50:  16nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455360(US10730881, Example 25q | (R)- or (S)-7-(4-Fluorop...)
Affinity DataEC50:  17nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455346(US10730881, Example 12 | 7-(4-Fluorophenyl)-N4,5,5...)
Affinity DataEC50:  19nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455337(US10730881, Example 4 | 7-(4-Fluorophenyl)-N2-((1R...)
Affinity DataEC50:  23nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455343(US10730881, Example 9 | 7-(3,4-Difluorophenyl)-N4,...)
Affinity DataEC50:  24nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455357(US10730881, Example 23 | 8-(4-Fluorophenyl)-N2-((1...)
Affinity DataEC50:  24nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455338(US10730881, Example 5 | N2-((1R,5S,8s)-3-(6-Chloro...)
Affinity DataEC50:  31nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455350(US10730881, Example 16 | 7-(2,4-Difluorophenyl)-N4...)
Affinity DataEC50:  31nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455342(US10730881, Example 8 | 7-(3,4-Difluorophenyl)-N4,...)
Affinity DataEC50:  33nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455335(US10730881, Example 2 | 7-(4-Fluorophenyl)-N4,5,5-...)
Affinity DataEC50:  34nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455356(US10730881, Example 22 | 8-(4-Fluorophenyl)-N4,5,5...)
Affinity DataEC50:  35nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455347(US10730881, Example 13 | 7-(3,3-Difluorocyclobutyl...)
Affinity DataEC50:  36nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455339(US10730881, Example 6 | 7-(4-Fluorophenyl)-N2-((1R...)
Affinity DataEC50:  46nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455352(US10730881, Example 18 | N2-((1R,5S,8s)-3-(6-Metho...)
Affinity DataEC50:  53nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455348(US10730881, Example 14 | 7-(3,3-Difluorocyclobutyl...)
Affinity DataEC50:  104nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM455351(US10730881, Example 17 | N4,5,5-Trimethyl-N2-((1R,...)
Affinity DataEC50:  111nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent