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Found
1
Enz. Inhib. hit(s) with Target = 'Amyloid-beta precursor protein' and Ligand = 'BDBM455353'
Target
Amyloid-beta precursor protein
(Homo sapiens (Human))
Hoffmann-La Roche
US Patent
Ligand
BDBM455353
(7-(2,4-Difluorophenyl)-N2-((1R,5S,8s)-3-(6-methoxy...)
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Affinity Data
EC50: 9nM
Assay Description:
Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...
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Target Info
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Ligand Info
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US Patent
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