Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 11307
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 2.20nMAssay Description:The activity of CSF1R kinase (CSF1R, SEQ ID NO: 1) was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 2.20nMAssay Description:The activity of CSF1R kinase (CSF1R, SEQ ID NO: 1) was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetMast/stem cell growth factor receptor Kit(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 6.90nMAssay Description:The activity of unphosphorylated c-KIT kinase (c-KIT, SEQ ID NO: 2) was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 7.10nMAssay Description:The activity of FLT3 kinase was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that continuously monitors t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 9.60nMAssay Description:The activity of unphosphorylated PDGFRα kinase was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 864nMAssay Description:The activity of unphosphorylated c-KIT kinase (c-KIT, SEQ ID NO: 2) was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 2.50E+3nMAssay Description:The activity of unphosphorylated PDGFRα kinase was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM50589669(Dcc-3014 | Vimseltinib | DCC-3014 | DP-6865 | VIMS...)
Affinity DataIC50: 2.70E+3nMAssay Description:The activity of FLT3 kinase was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that continuously monitors t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
US Patent