Compile Data Set for Download or QSAR
Report error Found 205 Enz. Inhib. hit(s) with all data for entry = 9920
TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499311(US11014963, Example 216)
Affinity DataIC50: 0.400nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499107(US11014963, Example 17)
Affinity DataIC50: 0.490nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499266(US11014963, Example 166)
Affinity DataIC50: 0.5nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499267(US11014963, Example 170)
Affinity DataIC50: 0.600nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499264(US11014963, Example 163)
Affinity DataIC50: 0.602nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499097(US11014963, Example 8)
Affinity DataIC50: 0.620nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499095(US11014963, Example 6)
Affinity DataIC50: 0.620nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499222((2S)-3-(3-Chlorophenyl)-2-[[2-(3-chlorophenyl)acet...)
Affinity DataIC50: 0.695nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499291((2S)-2-[[2-(2,5-Dichlorophenyl)-2,2-difluoroacetyl...)
Affinity DataIC50: 0.700nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499179(US11014963, Example 73)
Affinity DataIC50: 0.710nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499140(US11014963, Example 47)
Affinity DataIC50: 0.760nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499265(US11014963, Example 165)
Affinity DataIC50: 0.800nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499096(US11014963, Example 7)
Affinity DataIC50: 0.830nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499268(US11014963, Example 171)
Affinity DataIC50: 0.900nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499230(US11014963, Example 129)
Affinity DataIC50: 0.900nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499128(US11014963, Example 35)
Affinity DataIC50: 0.970nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499170(US11014963, Example 64)
Affinity DataIC50: 1nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499102(US11014963, Example 14 | US11014963, Example 13)
Affinity DataIC50: 1.10nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499307(US11014963, Example 212)
Affinity DataIC50: 1.10nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499110(US11014963, Example 20)
Affinity DataIC50: 1.10nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499109(US11014963, Example 19)
Affinity DataIC50: 1.10nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499108(US11014963, Example 18)
Affinity DataIC50: 1.20nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499089(N-[(2S)-3-(3-Chlorophenyl)-1-[[(1S)-1-(4-methoxyph...)
Affinity DataIC50: 1.20nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499223(US11014963, Example 122)
Affinity DataIC50: 1.20nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499271(US11014963, Example 175)
Affinity DataIC50: 1.20nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499283(US11014963, Example 188)
Affinity DataIC50: 1.30nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499169(US11014963, Example 63)
Affinity DataIC50: 1.40nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499233(US11014963, Example 132)
Affinity DataIC50: 1.40nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499297(US11014963, Example 202)
Affinity DataIC50: 1.40nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499228(US11014963, Example 127)
Affinity DataIC50: 1.40nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499098(US11014963, Example 9)
Affinity DataIC50: 1.40nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499132(US11014963, Example 39)
Affinity DataIC50: 1.40nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499199(US11014963, Example 98)
Affinity DataIC50: 1.5nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499231(US11014963, Example 130)
Affinity DataIC50: 1.5nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499178(US11014963, Example 72)
Affinity DataIC50: 1.5nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499127(US11014963, Example 34)
Affinity DataIC50: 1.60nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499281(US11014963, Example 186)
Affinity DataIC50: 1.70nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499137(US11014963, Example 44)
Affinity DataIC50: 1.70nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499224(US11014963, Example 123)
Affinity DataIC50: 1.70nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499135(US11014963, Example 42)
Affinity DataIC50: 1.80nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499242(US11014963, Example 141)
Affinity DataIC50: 1.80nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499092(US11014963, Example 4)
Affinity DataIC50: 1.80nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499119(US11014963, Example 29)
Affinity DataIC50: 1.82nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499136(US11014963, Example 43)
Affinity DataIC50: 1.90nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499306(N-[(5S)-5-[[2-(3,4-Dichlorophenyl)-2,2-difluoroace...)
Affinity DataIC50: 1.90nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499093(US11014963, Example 5)
Affinity DataIC50: 1.90nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499269(US11014963, Example 173)
Affinity DataIC50: 1.90nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499276(US11014963, Example 181)
Affinity DataIC50: 2nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499139(US11014963, Example 46)
Affinity DataIC50: 2.10nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499171(US11014963, Example 65)
Affinity DataIC50: 2.30nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

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