Compile Data Set for Download or QSAR
Report error Found 167 Enz. Inhib. hit(s) with all data for entry = 2293
TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360442(ethyl 3-(8-((2- phenylcyclopropanecarboxamido) met...)
Affinity DataIC50: 71nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360342(methyl 3-(8-(((1R,2R)-2- phenylcyclopropanecarboxa...)
Affinity DataIC50: 82.7nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360337(methyl 3-(8-((2-(4-(trifluoromethyl) phenyl)acetam...)
Affinity DataIC50: 85.6nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360343(methyl 3-(8-((2-(3-methyl-1,2,4- oxadiazol-5-yl)cy...)
Affinity DataIC50: 96.5nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360348(methyl 3-(8-((1-(4-(trifluoromethyl) phenyl)piperi...)
Affinity DataIC50: 100nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360433(methyl 3-(8-((2-(4-phenoxyphenyl) acetamido)methyl...)
Affinity DataIC50: 101nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360434(methyl 3-(8-((3-(tert-butyl)-1-methyl- 1H-pyrazole...)
Affinity DataIC50: 111nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360444(N-((5-(3-ethoxyphenyl)isoquinolin- 8-yl)methyl)-2-...)
Affinity DataIC50: 115nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360600(1-([1,1'-biphenyl]-3-yl)-3-((5(3- methoxyphenyl)is...)
Affinity DataIC50: 116nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360585((R/S)-2-(6-methoxynaphthalen-2-yl)- N-((5-(3-metho...)
Affinity DataIC50: 118nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360435(methyl 3-(8-((1-phenyl-5- (trifluoromethyl)-1H-pyr...)
Affinity DataIC50: 123nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360436(methyl 3-(8-((1-methyl-3-propyl-1H- pyrazole-5-car...)
Affinity DataIC50: 132nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360437(methyl 3-(8-((spiro[2.4]heptane-1- carboxamido)met...)
Affinity DataIC50: 162nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360438(8-((isoquinoline-1- carboxamido)methyl)-5-(3- (met...)
Affinity DataIC50: 164nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360545(2-(4-fluorophenyl)-N-((5-(3- methoxyphenyl)isoquin...)
Affinity DataIC50: 178nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360439(8-((isoquinoline-5- carboxamido)methyl)-5-(3- (me...)
Affinity DataIC50: 196nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360586(2-(6-methoxynaphthalen-2-yl)-N-((5- (3-methoxyphen...)
Affinity DataIC50: 197nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360595(1-(2,3-dichlorophenyl)-3-((5-(3,5- dimethoxyphenyl...)
Affinity DataIC50: 198nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360613(US9828369, Example 172)
Affinity DataIC50: 206nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360582(2-(2-fluorophenyl)-N-((5-(3- methoxyphenyl)isoquin...)
Affinity DataIC50: 213nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360542(2-(3-bromophenyl)-N-((5-(3- methoxyphenyl)isoquino...)
Affinity DataIC50: 230nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360543(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)sp...)
Affinity DataIC50: 243nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360579(2-(4-cyanophenyl)-N-((5-(3- methoxyphenyl)isoquino...)
Affinity DataIC50: 256nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360573(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)bi...)
Affinity DataIC50: 268nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360447(N-((5-(3- (methoxymethyl)phenyl)isoquinolin- 8-yl)...)
Affinity DataIC50: 278nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360489(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Affinity DataIC50: 291nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360581(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Affinity DataIC50: 298nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360537(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-3...)
Affinity DataIC50: 305nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360498(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Affinity DataIC50: 306nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360484(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Affinity DataIC50: 317nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360588(US9828369, Example 145 | (R/S)-2-(2-fluoro-[1,1'-b...)
Affinity DataIC50: 319nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360577(2-([1,1'-biphenyl]-4-yl)-N-((5-(3- methoxyphenyl)i...)
Affinity DataIC50: 324nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360569((R/S)-2-(3-fluoro-4- (trifluoromethyl)phenyl)-N-((...)
Affinity DataIC50: 373nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360601(1-(2,3-dichlorophenyl)-3-((5-(1- phenylyinyl)isoqu...)
Affinity DataIC50: 374nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360574(5-bromo-2-fluoro-N-((5-(3- methoxyphenyl)isoquinol...)
Affinity DataIC50: 400nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360593(N-((5-(3-methoxyphenyl)quinolin- 8-yl)methyl)-2-(4...)
Affinity DataIC50: 426nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360602(1-(2,3-dichlorophenyl)-3-((5-(3- methoxypropyl)iso...)
Affinity DataIC50: 478nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360509(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-1...)
Affinity DataIC50: 479nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360547(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Affinity DataIC50: 483nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360524(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Affinity DataIC50: 483nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360580(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Affinity DataIC50: 484nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360566(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-1...)
Affinity DataIC50: 513nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360451(US9828369, Example 23 | US9828369, Example 106 | (...)
Affinity DataIC50: 537nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360553(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-4...)
Affinity DataIC50: 544nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360502(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Affinity DataIC50: 550nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360584(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Affinity DataIC50: 566nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360576(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Affinity DataIC50: 571nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360452((cis)-2-(4-methoxyphenyl)-N-((5-(3- methoxyphenyl)...)
Affinity DataIC50: 589nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360551((trans)-N-((5-(3- methoxyphenyl)isoquinolin-8- yl)...)
Affinity DataIC50: 589nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360540(2-(4-chlorophenyl)-N-((5-(3 methoxyphenyl)isoquino...)
Affinity DataIC50: 597nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

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