Compile Data Set for Download or QSAR
Report error Found 169 Enz. Inhib. hit(s) with all data for entry = 2653
LigandChemical structure of BindingDB Monomer ID 375168BDBM375168(6-{[(1S)-1-[6-chloro-2-oxo- | US10253015, Compound...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375168BDBM375168(6-{[(1S)-1-[6-chloro-2-oxo- | US10253015, Compound...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375145BDBM375145(6-{[(1S)-1-(6-chloro-2- | US10253015, Compound I-5)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375169BDBM375169(6-({1-[6-chloro-2-oxo-7- | US10253015, Compound I-...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375168BDBM375168(6-{[(1S)-1-[6-chloro-2-oxo- | US10253015, Compound...)
Affinity DataIC50: 10nMAssay Description:HCT116 isogenic IDH1-R132H and IDH1-R132C mutant cells were cultured in growth media (McCoy's 5 A, 10% fetal bovine serum, 1× antibiotic-antimyco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375146BDBM375146(6-{[(1S)-1-(6-chloro-2- | US10253015, Compound I-6)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375166BDBM375166(6-{[(1S)-1-(6-chloro-7- | US10253015, Compound I-2...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375166BDBM375166(6-{[(1S)-1-(6-chloro-7- | US10253015, Compound I-2...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375198BDBM375198(6-{[(6-chloro-2-oxo-1,2- | US10253015, Compound I-...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 375167BDBM375167(6-{[(1S)-1-(6-chloro-7- | US10253015, Compound I-2...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375201BDBM375201(5-{[(6-chloro-2-oxo-1,2- | US10253015, Compound I-...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375167BDBM375167(6-{[(1S)-1-(6-chloro-7- | US10253015, Compound I-2...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375166BDBM375166(6-{[(1S)-1-(6-chloro-7- | US10253015, Compound I-2...)
Affinity DataIC50: 10nMAssay Description:HCT116 isogenic IDH1-R132H and IDH1-R132C mutant cells were cultured in growth media (McCoy's 5 A, 10% fetal bovine serum, 1× antibiotic-antimyco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375144BDBM375144(6-{[(1S)-1-(6-chloro-2- | US10253015, Compound I-4)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375151BDBM375151(6-chloro-3-[(1S)-1-{[6-(2- | US10253015, Compound ...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375150BDBM375150(6-chloro-3-[(1S)-1-{[4-(2- | US10253015, Compound ...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375174BDBM375174(N-(2-{[(1S)-1-(6-chloro-2- | US10253015, Compound ...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375223BDBM375223(6-{[(6-chloro-7-methoxy-2-oxo-1,2- | US10253015, C...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375170BDBM375170(6-[(1-{6-chloro-7-[(3,3- | US10253015, Compound I-...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375147BDBM375147(5-{[(1S)-1-(6-chloro-2- | US10253015, Compound I-7)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375161BDBM375161(6-{[1-(6-chloro-7-fluoro-2- | US10253015, Compound...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375225BDBM375225(6-[({6-chloro-7-[2-(4- | US10253015, Compound I-85)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375154BDBM375154(6-chloro-3-[(1S)-1-{[3- | US10253015, Compound I-1...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375164BDBM375164(6-{[1-(6-chloro-7-methoxy- | US10253015, Compound ...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375165BDBM375165(6-{[(1S)-1-(6-chloro-7- | US10253015, Compound I-2...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375165BDBM375165(6-{[(1S)-1-(6-chloro-7- | US10253015, Compound I-2...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375141BDBM375141(6-{[(1S)-1-(6-chloro-2- | US10253015, Compound I-1)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375162BDBM375162(6-{[(1S)-1-(6-chloro-7- | US10253015, Compound I-2...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375163BDBM375163(6-{[(1S)-1-(6-chloro-7- | US10253015, Compound I-2...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375163BDBM375163(6-{[(1S)-1-(6-chloro-7- | US10253015, Compound I-2...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375162BDBM375162(6-{[(1S)-1-(6-chloro-7- | US10253015, Compound I-2...)
Affinity DataIC50: 10nMAssay Description:HCT116 isogenic IDH1-R132H and IDH1-R132C mutant cells were cultured in growth media (McCoy's 5 A, 10% fetal bovine serum, 1× antibiotic-antimyco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375145BDBM375145(6-{[(1S)-1-(6-chloro-2- | US10253015, Compound I-5)
Affinity DataIC50: 55nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375167BDBM375167(6-{[(1S)-1-(6-chloro-7- | US10253015, Compound I-2...)
Affinity DataIC50: 55nMAssay Description:HCT116 isogenic IDH1-R132H and IDH1-R132C mutant cells were cultured in growth media (McCoy's 5 A, 10% fetal bovine serum, 1× antibiotic-antimyco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375169BDBM375169(6-({1-[6-chloro-2-oxo-7- | US10253015, Compound I-...)
Affinity DataIC50: 55nMAssay Description:HCT116 isogenic IDH1-R132H and IDH1-R132C mutant cells were cultured in growth media (McCoy's 5 A, 10% fetal bovine serum, 1× antibiotic-antimyco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375208BDBM375208(6-chloro-3-({[3-(propan-2-yl)pyridin-2- | US102530...)
Affinity DataIC50: 55nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375146BDBM375146(6-{[(1S)-1-(6-chloro-2- | US10253015, Compound I-6)
Affinity DataIC50: 55nMAssay Description:HCT116 isogenic IDH1-R132H and IDH1-R132C mutant cells were cultured in growth media (McCoy's 5 A, 10% fetal bovine serum, 1× antibiotic-antimyco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375207BDBM375207(6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3- | US102...)
Affinity DataIC50: 55nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375146BDBM375146(6-{[(1S)-1-(6-chloro-2- | US10253015, Compound I-6)
Affinity DataIC50: 55nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375168BDBM375168(6-{[(1S)-1-[6-chloro-2-oxo- | US10253015, Compound...)
Affinity DataIC50: 55nMAssay Description:HCT116 isogenic IDH1-R132H and IDH1-R132C mutant cells were cultured in growth media (McCoy's 5 A, 10% fetal bovine serum, 1× antibiotic-antimyco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375198BDBM375198(6-{[(6-chloro-2-oxo-1,2- | US10253015, Compound I-...)
Affinity DataIC50: 55nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 375165BDBM375165(6-{[(1S)-1-(6-chloro-7- | US10253015, Compound I-2...)
Affinity DataIC50: 55nMAssay Description:HCT116 isogenic IDH1-R132H and IDH1-R132C mutant cells were cultured in growth media (McCoy's 5 A, 10% fetal bovine serum, 1× antibiotic-antimyco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375166BDBM375166(6-{[(1S)-1-(6-chloro-7- | US10253015, Compound I-2...)
Affinity DataIC50: 55nMAssay Description:HCT116 isogenic IDH1-R132H and IDH1-R132C mutant cells were cultured in growth media (McCoy's 5 A, 10% fetal bovine serum, 1× antibiotic-antimyco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375144BDBM375144(6-{[(1S)-1-(6-chloro-2- | US10253015, Compound I-4)
Affinity DataIC50: 55nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375199BDBM375199(6-{[(6-chloro-2-oxo-1,2- | US10253015, Compound I-...)
Affinity DataIC50: 55nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375220BDBM375220(6-{[(6,7-dimethyl-2-oxo-1,2-dihydroquinolin- | US1...)
Affinity DataIC50: 55nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375174BDBM375174(N-(2-{[(1S)-1-(6-chloro-2- | US10253015, Compound ...)
Affinity DataIC50: 55nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375152BDBM375152(6-chloro-3-[(1S)-1-{[6- | US10253015, Compound I-1...)
Affinity DataIC50: 55nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375151BDBM375151(6-chloro-3-[(1S)-1-{[6-(2- | US10253015, Compound ...)
Affinity DataIC50: 55nMAssay Description:HCT116 isogenic IDH1-R132H and IDH1-R132C mutant cells were cultured in growth media (McCoy's 5 A, 10% fetal bovine serum, 1× antibiotic-antimyco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375151BDBM375151(6-chloro-3-[(1S)-1-{[6-(2- | US10253015, Compound ...)
Affinity DataIC50: 55nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 375170BDBM375170(6-[(1-{6-chloro-7-[(3,3- | US10253015, Compound I-...)
Affinity DataIC50: 55nMAssay Description:HCT116 isogenic IDH1-R132H and IDH1-R132C mutant cells were cultured in growth media (McCoy's 5 A, 10% fetal bovine serum, 1× antibiotic-antimyco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

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