Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 1352
TargetAlpha-1A adrenergic receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 317578BDBM317578([4-(3,4-Dihydroisoquinolin-2(1H)-yl)piperidin-1-yl...)
Affinity DataIC50: 9nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetAlpha-1A adrenergic receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 317585BDBM317585([4-(3,4-Dihydroisoquinolin-2(1H)-yl)piperidin-1-yl...)
Affinity DataIC50: 11nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetAlpha-1A adrenergic receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 317584BDBM317584([4-(6-Methoxy-3,4-dihydroisoquinolin-2(1H)-yl)pipe...)
Affinity DataIC50: 11nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetAlpha-1A adrenergic receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 317586BDBM317586(US9624198, 11 | US9624198, 12 | [4-(3,4-Dihydroiso...)
Affinity DataIC50: 11nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetAlpha-1A adrenergic receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 317577BDBM317577([4-(7-Fluoro-3,4-dihydroisoquinolin-2(1H)-yl)piper...)
Affinity DataIC50: 13nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetAlpha-1A adrenergic receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 317582BDBM317582([4-(3,4-Dihydroisoquinolin-2(1H)-yl)piperidin-1-yl...)
Affinity DataIC50: 21nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetAlpha-1A adrenergic receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 317586BDBM317586(US9624198, 11 | US9624198, 12 | [4-(3,4-Dihydroiso...)
Affinity DataIC50: 21nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetAlpha-1A adrenergic receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 317576BDBM317576( [4-(3,4-Dihydroisoquinolin-2-(1H)-yl)piperidin-1-...)
Affinity DataIC50: 22nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetAlpha-1A adrenergic receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 317589BDBM317589(US9624198, 14 | [4-(3,4-Dihydroisoquinolin-2(1H)-y...)
Affinity DataIC50: 23nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetAlpha-1A adrenergic receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 317579BDBM317579([4-(3,4-Dihydroisoquinolin-2(1H)-yl)piperidin-1-yl...)
Affinity DataIC50: 24nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetAlpha-1A adrenergic receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 317581BDBM317581(1-(5-{[4-(3,4-Dihydroisoquinolin-2(1H)-yl)piperidi...)
Affinity DataIC50: 27nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetAlpha-1A adrenergic receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 317588BDBM317588(US9624198, 13 | [4-(3,4-Dihydroisoquinolin-2(1H)-y...)
Affinity DataIC50: 53nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetAlpha-1A adrenergic receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 317590BDBM317590(US9624198, 15 | [4-(3,4-Dihydroisoquinolin-2(1H)-y...)
Affinity DataIC50: 53nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetAlpha-1A adrenergic receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 317583BDBM317583([4-(6-Fluoro-3,4-dihydroisoquinolin-2(1H)-yl)piper...)
Affinity DataIC50: 58nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetAlpha-1A adrenergic receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 317580BDBM317580([4-(3,4-Dihydroisoquinolin-2(1H)-yl)piperidin-1-yl...)
Affinity DataIC50: 65nMAssay Description:Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent