Compile Data Set for Download or QSAR
Report error Found 130 Enz. Inhib. hit(s) with all data for entry = 10567
TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 299190BDBM299190(US10125144, Example 18 | N-(4-(1H-pyrazol-4-yl)phe...)
Affinity DataIC50: 2nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 299173BDBM299173(US10125144, Example 1 | N-(2-(5-Methoxyisoindolin-...)
Affinity DataIC50: 2nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 299173BDBM299173(US10125144, Example 1 | N-(2-(5-Methoxyisoindolin-...)
Affinity DataIC50: 10nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 299188BDBM299188(US10125144, Example 16 | N-(2-(5-Methoxyisoindolin...)
Affinity DataIC50: 10nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 299179BDBM299179(US10125144, Example 7 | N-(1H-Indazol-5-yl)-2-(5-m...)
Affinity DataIC50: 10nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322158BDBM322158(US10183931, Example 48 | 2-(3-(4-((1H-indazol-5-yl...)
Affinity DataKi:  10nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322176BDBM322176(US10183931, Example 176 | US10696660, Example 176 ...)
Affinity DataIC50: 13nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322165BDBM322165(US10183931, Example 166 | US10696660, Example 166 ...)
Affinity DataIC50: 20nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322152BDBM322152(US10183931, Example 12 | (R)-2-(3-(4-((1H-indazol-...)
Affinity DataKi:  20nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322158BDBM322158(US10183931, Example 48 | 2-(3-(4-((1H-indazol-5-yl...)
Affinity DataKi:  20nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 299178BDBM299178(US10125144, Example 6 | N-(2-(5-Methoxyisoindolin-...)
Affinity DataIC50: 30nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322172BDBM322172(US10183931, Example 173 | US10696660, Example 173 ...)
Affinity DataIC50: 30nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 299175BDBM299175(US10125144, Example 3 | N-(5-Fluoro-2-(5-methoxyis...)
Affinity DataIC50: 30nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322174BDBM322174(US10183931, Example 17 | N-(3-(4-((1H-indazol-5-yl...)
Affinity DataIC50: 30nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322153BDBM322153(US10183931, Example 26 | 2-(3-(4-((1H-indazol-5-yl...)
Affinity DataIC50: 30nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322167BDBM322167(US10183931, Example 168 | US10696660, Example 168 ...)
Affinity DataIC50: 30nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322153BDBM322153(US10183931, Example 26 | 2-(3-(4-((1H-indazol-5-yl...)
Affinity DataKi:  30nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 299192BDBM299192(US10125144, Example 20 | 2-(5-Methoxyisoindolin-2-...)
Affinity DataIC50: 35nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 299181BDBM299181(US10125144, Example 9 | N-(2-(5-Fluoroisoindolin-2...)
Affinity DataIC50: 40nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322155BDBM322155(US11311541, Example SLx-2119 | US10696660, SLx-211...)
Affinity DataKi:  40nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322182BDBM322182(US10183931, Example 154 | N-(2-(3-(2-(isopropylami...)
Affinity DataIC50: 40nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 448554BDBM448554(US10696660, Y-27263 | US11311541, Example Y-27263)
Affinity DataKi:  40nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322162BDBM322162(US10183931, Example 118 | 2-(3-(4-((1H-indazol-5-y...)
Affinity DataIC50: 40nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 299192BDBM299192(US10125144, Example 20 | 2-(5-Methoxyisoindolin-2-...)
Affinity DataIC50: 40nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322164BDBM322164(US10183931, Example 165 | US10696660, Example 165 ...)
Affinity DataIC50: 50nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 299177BDBM299177(US10125144, Example 5 | N-(2-(5-Methoxyisoindolin-...)
Affinity DataIC50: 50nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 299174BDBM299174(US10125144, Example 2 | N-(2-(Isoindolin-2-yl)pyri...)
Affinity DataIC50: 60nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322166BDBM322166(US10183931, Example 167 | US10696660, Example 167 ...)
Affinity DataIC50: 60nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 448554BDBM448554(US10696660, Y-27263 | US11311541, Example Y-27263)
Affinity DataKi:  60nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322163BDBM322163(US10183931, Example 164 | US10696660, Example 164 ...)
Affinity DataIC50: 60nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322154BDBM322154(US10183931, Example 28 | 2-(3-(4-((1H-indazol-5-yl...)
Affinity DataIC50: 70nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322160BDBM322160(US10183931, Example 5 | 2-(3-(4-((1H-indazol-5-yl)...)
Affinity DataIC50: 70nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322152BDBM322152(US10183931, Example 12 | (R)-2-(3-(4-((1H-indazol-...)
Affinity DataKi:  70nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322169BDBM322169(US10183931, Example 170 | US10696660, Example 170 ...)
Affinity DataIC50: 70nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322154BDBM322154(US10183931, Example 28 | 2-(3-(4-((1H-indazol-5-yl...)
Affinity DataKi:  80nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322161BDBM322161(US10183931, Example 163 | US10696660, Example 163 ...)
Affinity DataIC50: 80nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322170BDBM322170(US10183931, Example 171 | US10696660, Example 171 ...)
Affinity DataIC50: 80nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322184BDBM322184(US10183931, Example 159 | N-(2-(3-methoxyphenyl)-6...)
Affinity DataIC50: 100nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 299182BDBM299182(US10125144, Example 10 | N-(2-(5-Chloroisoindolin-...)
Affinity DataIC50: 110nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322171BDBM322171(US10183931, Example 172 | US10696660, Example 172 ...)
Affinity DataIC50: 120nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 299185BDBM299185(US10125144, Example 13 | N-(6-(5-Methoxyisoindolin...)
Affinity DataIC50: 130nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 299176BDBM299176(US10125144, Example 4 | N-(5-Chloro-2-(5-methoxyis...)
Affinity DataIC50: 140nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 299186BDBM299186(US10125144, Example 14 | N-(6-(5-Methoxyisoindolin...)
Affinity DataIC50: 155nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322157BDBM322157(US10183931, Example 14 | 2-(3-(4-((1H-indazol-5-yl...)
Affinity DataKi:  170nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322159BDBM322159(US10183931, Example 13 | (R)-2-(3-(4-((1H-indazol-...)
Affinity DataKi:  180nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 299176BDBM299176(US10125144, Example 4 | N-(5-Chloro-2-(5-methoxyis...)
Affinity DataIC50: 190nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322173BDBM322173(US10183931, Example 174 | US10696660, Example 174 ...)
Affinity DataIC50: 191nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322184BDBM322184(US10183931, Example 159 | N-(2-(3-methoxyphenyl)-6...)
Affinity DataIC50: 200nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322154BDBM322154(US10183931, Example 28 | 2-(3-(4-((1H-indazol-5-yl...)
Affinity DataKi:  260nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 322158BDBM322158(US10183931, Example 48 | 2-(3-(4-((1H-indazol-5-yl...)
Affinity DataIC50: 300nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

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