Compile Data Set for Download or QSAR
Report error Found 460 Enz. Inhib. hit(s) with all data for entry = 11501
TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621115(US20230303563, Compound 117)
Affinity DataKd:  0.00700nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621123(US20230303563, Compound 165)
Affinity DataKd:  0.00700nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621165(Exemplary Synthetic Procedure #38 | US20230303563...)
Affinity DataKd:  0.00800nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621126(6-(6- (difluoromethyl)imidazo[1,2- a]pyridin-3-yl)...)
Affinity DataKd:  0.00900nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621169(6-(6- (difluoromethyl)imidazo[1,2- a]pyridin-3-yl)...)
Affinity DataKd:  0.00900nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621116(2-(3-(6-(((3S,4S)-4- fluoropyrrolidin-3- yl)amino)...)
Affinity DataKd:  0.00900nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621130(N-(6-(6- (difluoromethyl)imidazo[1,2- a]pyridin-3-...)
Affinity DataKd:  0.0100nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621115(US20230303563, Compound 117)
Affinity DataKd:  0.0110nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621098(6-(6-(difluorometh- oxy)imidazo[1,2-a]- pyridin-3-...)
Affinity DataKd:  0.0110nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621168(6-(6-(1-cyclopropyl-1H- pyrazol-4-yl)imidazo- [1,2...)
Affinity DataKd:  0.0110nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [F691L](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621115(US20230303563, Compound 117)
Affinity DataKd:  0.0120nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621166(N-((3S,4S)-4-fluoro- pyrrolidin-3-yl)-6-(6-(1- met...)
Affinity DataKd:  0.0120nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621098(6-(6-(difluorometh- oxy)imidazo[1,2-a]- pyridin-3-...)
Affinity DataKd:  0.0120nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621169(6-(6- (difluoromethyl)imidazo[1,2- a]pyridin-3-yl)...)
Affinity DataKd:  0.0140nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621167(1-(4-(3-(6-(((3S,4S)-4- fluoropyrrolidin-3-yl)- am...)
Affinity DataKd:  0.0160nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621117(2-(3-(6-(((3S,4S)-4- fluoropiperidin-3- yl)amino)p...)
Affinity DataKd:  0.0170nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621126(6-(6- (difluoromethyl)imidazo[1,2- a]pyridin-3-yl)...)
Affinity DataKd:  0.0170nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621161(N-((3S,4S)-4- fluoropyrrolidin-3-yl)-6-(7- isoprop...)
Affinity DataKd:  0.0180nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621125((R)-N-(6-(6- (difluoromethyl)imidazo[1,2- a]pyridi...)
Affinity DataKd:  0.0200nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621166(N-((3S,4S)-4-fluoro- pyrrolidin-3-yl)-6-(6-(1- met...)
Affinity DataKd:  0.0200nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621126(6-(6- (difluoromethyl)imidazo[1,2- a]pyridin-3-yl)...)
Affinity DataKd:  0.0210nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621130(N-(6-(6- (difluoromethyl)imidazo[1,2- a]pyridin-3-...)
Affinity DataKd:  0.0230nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621115(US20230303563, Compound 117)
Affinity DataKd:  0.0240nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621123(US20230303563, Compound 165)
Affinity DataKd:  0.0250nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621165(Exemplary Synthetic Procedure #38 | US20230303563...)
Affinity DataKd:  0.0250nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [F691L](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621126(6-(6- (difluoromethyl)imidazo[1,2- a]pyridin-3-yl)...)
Affinity DataKd:  0.0250nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621137(3,5-difluoro-N-((3S,4S)-4- fluoropiperidin-3-yl)-6...)
Affinity DataKd:  0.0250nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621098(6-(6-(difluorometh- oxy)imidazo[1,2-a]- pyridin-3-...)
Affinity DataKd:  0.0290nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [F691L](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621098(6-(6-(difluorometh- oxy)imidazo[1,2-a]- pyridin-3-...)
Affinity DataKd:  0.0300nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621168(6-(6-(1-cyclopropyl-1H- pyrazol-4-yl)imidazo- [1,2...)
Affinity DataKd:  0.0300nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [F691L](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621169(6-(6- (difluoromethyl)imidazo[1,2- a]pyridin-3-yl)...)
Affinity DataKd:  0.0330nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621080(N-(6-(6-(1-methyl- cyclopropyl)imidazo- [1,2-a]pyr...)
Affinity DataKd:  0.0340nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621117(2-(3-(6-(((3S,4S)-4- fluoropiperidin-3- yl)amino)p...)
Affinity DataKd:  0.0340nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621169(6-(6- (difluoromethyl)imidazo[1,2- a]pyridin-3-yl)...)
Affinity DataKd:  0.0350nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621126(6-(6- (difluoromethyl)imidazo[1,2- a]pyridin-3-yl)...)
Affinity DataKd:  0.0360nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835H](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621115(US20230303563, Compound 117)
Affinity DataKd:  0.0380nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621125((R)-N-(6-(6- (difluoromethyl)imidazo[1,2- a]pyridi...)
Affinity DataKd:  0.0410nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 (D835Y)(Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621098(6-(6-(difluorometh- oxy)imidazo[1,2-a]- pyridin-3-...)
Affinity DataKd:  0.0470nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621136(3,5-difluoro-N-((3S,4S)-4- fluoropyrrolidin-3-yl)-...)
Affinity DataKd:  0.0490nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [N841I](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621115(US20230303563, Compound 117)
Affinity DataKd:  0.0510nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621116(2-(3-(6-(((3S,4S)-4- fluoropyrrolidin-3- yl)amino)...)
Affinity DataKd:  0.0520nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [F691L](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621117(2-(3-(6-(((3S,4S)-4- fluoropiperidin-3- yl)amino)p...)
Affinity DataKd:  0.0560nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621167(1-(4-(3-(6-(((3S,4S)-4- fluoropyrrolidin-3-yl)- am...)
Affinity DataKd:  0.0590nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621130(N-(6-(6- (difluoromethyl)imidazo[1,2- a]pyridin-3-...)
Affinity DataKd:  0.0600nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621115(US20230303563, Compound 117)
Affinity DataKd:  0.0610nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621137(3,5-difluoro-N-((3S,4S)-4- fluoropiperidin-3-yl)-6...)
Affinity DataKd:  0.0620nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621161(N-((3S,4S)-4- fluoropyrrolidin-3-yl)-6-(7- isoprop...)
Affinity DataKd:  0.0690nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3 [F691L](Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621137(3,5-difluoro-N-((3S,4S)-4- fluoropiperidin-3-yl)-6...)
Affinity DataKd:  0.0710nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621117(2-(3-(6-(((3S,4S)-4- fluoropiperidin-3- yl)amino)p...)
Affinity DataKd:  0.0740nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 (D835Y)(Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM621165(Exemplary Synthetic Procedure #38 | US20230303563...)
Affinity DataKd:  0.0750nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

Displayed 1 to 50 (of 460 total ) | Next | Last >>
Jump to: