Compile Data Set for Download or QSAR
Report error Found 326 Enz. Inhib. hit(s) with all data for entry = 512
TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275221BDBM275221(1-[(3R,4S)-1-methyl-4-(2- phenylethyl)pyrrolidin-3...)
Affinity DataIC50: 0.180nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275295BDBM275295(1-[(3R,4S)-1-methyl-4-(5- methylthiophen-2-yl)pyrr...)
Affinity DataIC50: 0.25nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275140BDBM275140(1-[(3R,4S) or (3S, 4R)-1- methyl-4-(2- methylpheny...)
Affinity DataIC50: 0.280nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275404BDBM275404(1-[(3R)-1-(2,6- difluorobenzyl)pyrrolidin-3- yl]-3...)
Affinity DataIC50: 0.320nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275313BDBM275313(1-[(1S)-2-hydroxy-2-methyl-1- phenylpropyl]-3[-1-(...)
Affinity DataIC50: 0.330nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275136BDBM275136(N-{3-[({[1-(2- methylpyridin-4-yl)-1H- pyrazolo[3,...)
Affinity DataIC50: 0.440nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275207BDBM275207(1-[(2S,3S,4R)-1,2-dimethyl- 4-(2-methylphenyl)- py...)
Affinity DataIC50: 0.5nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275145BDBM275145(1-(3-chlorobenzyl)-3-(1- pyridin-4-yl-1H- pyrazolo...)
Affinity DataIC50: 0.5nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275297BDBM275297(1-[1-(2-methylpyridin-4-yl)- 1H-pyrazolo[3,4-c]pyr...)
Affinity DataIC50: 0.510nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275162BDBM275162(1-[(3R)-1-(2-fluoro-6- methoxybenzyl)piperidin-3- ...)
Affinity DataIC50: 0.520nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275413BDBM275413((S)-1-(2-methyl-2-hydroxy-1-phenylpropyl)-3-(1-(2-...)
Affinity DataIC50: 0.560nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275314BDBM275314(1-[1-(4-fluorophenyl)-1H- pyrazolo[3,4-c]pyridin-5...)
Affinity DataIC50: 0.580nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275196BDBM275196(1-[(1S)-2-methoxy-1- phenylethyl]-3-[1-(2- methylp...)
Affinity DataIC50: 0.680nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275307BDBM275307(1-[(7S,8S)-5-methyl-8- phenyl-2-oxa-5- azaspiro[3....)
Affinity DataIC50: 0.690nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275221BDBM275221(1-[(3R,4S)-1-methyl-4-(2- phenylethyl)pyrrolidin-3...)
Affinity DataIC50: 0.690nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275293BDBM275293(1-[(1S)-2-amino-1-phenylethyl]- 3-[1-(2-methylpyri...)
Affinity DataIC50: 0.690nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275305BDBM275305(1-[(3R,4S)-1-ethyl-4- phenylpyrrolidin-3-yl]-3-[1-...)
Affinity DataIC50: 0.720nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275241BDBM275241(1-[(1S)-2-(1-methylethoxy)- 1-phenylethyl]-3-[1-(2...)
Affinity DataIC50: 0.790nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275417BDBM275417(1-[1-(4-fluorophenyl)-1H-pyrazolo[3,4- c]pyridin-5...)
Affinity DataIC50: 0.810nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275163BDBM275163(1-(1-methyl-4- phenylpyrrolidin-3-yl)-3-[1- (2-met...)
Affinity DataIC50: 0.820nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275195BDBM275195(1-[(1R)-3-hydroxy-1- phenylpropyl]-3-[1-(2- methyl...)
Affinity DataIC50: 0.820nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275140BDBM275140(1-[(3R,4S) or (3S, 4R)-1- methyl-4-(2- methylpheny...)
Affinity DataIC50: 0.830nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275117BDBM275117(1-(3,4-dichlorobenzyl)-3-(1- pyridin-4-yl-1H-pyraz...)
Affinity DataIC50: 0.900nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275121BDBM275121(1-[(3R,4S)-4-(2- chlorophenyl)-1- methylpyrrolidin...)
Affinity DataIC50: 0.950nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275147BDBM275147(1-[(1R)-1-(3- chlorophenyl)ethyl]-3-[1-(2- methylp...)
Affinity DataIC50: 0.950nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275168BDBM275168(1-(2-amino-1-phenylethyl)- 3-[1-(2-methylpyridin-4...)
Affinity DataIC50: 0.960nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275287BDBM275287(1-((3S,4R)1-methyl-4-phenyl- pyrrolidin-3-yl)-3-[1...)
Affinity DataIC50: 0.980nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275312BDBM275312(1-[(1S)-2-hydroxy-2-methyl-1- phenylpropyl]-3-[1-(...)
Affinity DataIC50: 0.990nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275392BDBM275392(1-[1-(2,6- difluorobenzyl)pyrrolidin-3- yl]-3-[1-(...)
Affinity DataIC50: 1nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275230BDBM275230(1-[(3S,4R)-1-methyl-4-(5- methylthiophen-2- yl)pyr...)
Affinity DataIC50: 1.01nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275165BDBM275165(1-[1-(2-methylpyridin-4-yl)- 1H-pyrazolo[3,4-c]pyr...)
Affinity DataIC50: 1.01nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275171BDBM275171(1-[(1S)-2-hydroxy-1- phenylethyl]-3-[1-(2- methylp...)
Affinity DataIC50: 1.02nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275418BDBM275418((S)-1-(2-hydroxy-1-phenylpropyl)-3-(1-(2-methylpyr...)
Affinity DataIC50: 1.06nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275415BDBM275415(1-[(1S)-1-(4-fluorophenyl)-2-hydroxy-2- methylprop...)
Affinity DataIC50: 1.08nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275235BDBM275235(1-[(1S)-2-ethoxy-1- phenylethyl]-3-[1-(2- methylpy...)
Affinity DataIC50: 1.09nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275248BDBM275248((2S)-N-methyl-2-({[1-(2- methylpyridin-4-yl)-1H- p...)
Affinity DataIC50: 1.09nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275270BDBM275270(1-[(3R,4S)-4-(5- cyclopropylthiophen-2-yl)- 1-meth...)
Affinity DataIC50: 1.13nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275209BDBM275209(1-[1-(2-methylpyridin-4-yl)- 1H-pyrazolo[3,4-c]pyr...)
Affinity DataIC50: 1.14nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275255BDBM275255(1-[(3R,4S)-1-methyl-4-(3- phenylpropyl)pyrrolidin-...)
Affinity DataIC50: 1.18nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275416BDBM275416(1-[(1S)-1-(4-fluorophenyl)-2-hydroxy-2- methylprop...)
Affinity DataIC50: 1.29nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275199BDBM275199(1-[1-(2-methylpyridin-4-yl)- 1H-pyrazolo[3,4-c]pyr...)
Affinity DataIC50: 1.44nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275212BDBM275212(1-[(3S,4S,5R)-1,5-dimethyl- 4-(2-methylphenyl)- py...)
Affinity DataIC50: 1.52nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275139BDBM275139(1-[1-(2-methyl-2H-indazol- 5-yl)-1H-pyrazolo[3,4- ...)
Affinity DataIC50: 1.56nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275204BDBM275204(1-(3-isoxazol-3-ylbenzyl)-3- [1-(2-methylpyridin-4...)
Affinity DataIC50: 1.68nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275109BDBM275109(1-(4-fluorobenzyl)-3-(1-pyridin-4- yl-1H-pyrazolo[...)
Affinity DataIC50: 1.80nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275122BDBM275122(1-[1-(2-methylpyridin-4-yl)- 1H-pyrazolo[3,4-c]pyr...)
Affinity DataIC50: 1.83nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275123BDBM275123(1-[(3R,4S)-4-(3-chloro-4- fluorophenyl)-1- methylp...)
Affinity DataIC50: 2.14nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275220BDBM275220(1-[(5-methyl-3-phenyl- isoxazol-4-yl)methyl]-3-[1-...)
Affinity DataIC50: 2.14nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275211BDBM275211(1-[(3S,4S,5S)-1,5-dimethyl- 4-(2-methylphenyl)- py...)
Affinity DataIC50: 2.15nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 275329BDBM275329((R)-1-(1-(4-fluorophenyl)ethyl)-3-(1-(2-methylpyri...)
Affinity DataIC50: 2.28nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

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