Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 838
TargetProthrombin(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294039BDBM294039(US10106557, Compound 1 | Process 1)
Affinity DataKi:  0.470nMpH: 7.4Assay Description:The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetProthrombin(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294042BDBM294042(US10106557, Compound 8)
Affinity DataKi:  0.900nMpH: 7.4Assay Description:The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetCoagulation factor X(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294039BDBM294039(US10106557, Compound 1 | Process 1)
Affinity DataKi:  1.01nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetCoagulation factor X(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294042BDBM294042(US10106557, Compound 8)
Affinity DataKi:  1.92nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetCoagulation factor X(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 50024354BDBM50024354(CHEMBL3330444 | US10106557, Compound 2)
Affinity DataKi:  1.93nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetCoagulation factor X(Rat)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294039BDBM294039(US10106557, Compound 1 | Process 1)
Affinity DataKi:  2.87nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetCoagulation factor X(Rat)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294042BDBM294042(US10106557, Compound 8)
Affinity DataKi:  3.17nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetCoagulation factor X(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294041BDBM294041(US10106557, Compound 7)
Affinity DataKi:  4.13nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetProthrombin(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 50024354BDBM50024354(CHEMBL3330444 | US10106557, Compound 2)
Affinity DataKi:  4.22nMpH: 7.4Assay Description:The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetProthrombin(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294041BDBM294041(US10106557, Compound 7)
Affinity DataKi:  4.41nMpH: 7.4Assay Description:The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetCoagulation factor X(Rat)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 50024354BDBM50024354(CHEMBL3330444 | US10106557, Compound 2)
Affinity DataKi:  4.45nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetCoagulation factor X(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294043BDBM294043(US10106557, Compound 30)
Affinity DataKi:  9.71nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetProthrombin(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294043BDBM294043(US10106557, Compound 30)
Affinity DataKi:  16.2nMpH: 7.4Assay Description:The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetCoagulation factor X(Rat)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294041BDBM294041(US10106557, Compound 7)
Affinity DataKi:  16.5nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetCoagulation factor X(Rat)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294043BDBM294043(US10106557, Compound 30)
Affinity DataKi:  21.5nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetCoagulation factor X(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294044BDBM294044(US10106557, Compound 34)
Affinity DataKi:  106nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetProthrombin(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294042BDBM294042(US10106557, Compound 8)
Affinity DataKi: >1.00E+3nMpH: 7.4Assay Description:The inhibitory activity on human thrombin was determined by using a buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2). Appropriate wells in the Greiner...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetProthrombin(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294039BDBM294039(US10106557, Compound 1 | Process 1)
Affinity DataKi: >1.00E+3nMpH: 7.4Assay Description:The inhibitory activity on human thrombin was determined by using a buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2). Appropriate wells in the Greiner...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetProthrombin(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294043BDBM294043(US10106557, Compound 30)
Affinity DataKi: >1.00E+3nMpH: 7.4Assay Description:The inhibitory activity on human thrombin was determined by using a buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2). Appropriate wells in the Greiner...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetProthrombin(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 50024354BDBM50024354(CHEMBL3330444 | US10106557, Compound 2)
Affinity DataKi: >1.00E+3nMpH: 7.4Assay Description:The inhibitory activity on human thrombin was determined by using a buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2). Appropriate wells in the Greiner...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetProthrombin(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294041BDBM294041(US10106557, Compound 7)
Affinity DataKi: >1.00E+3nMpH: 7.4Assay Description:The inhibitory activity on human thrombin was determined by using a buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2). Appropriate wells in the Greiner...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetSerine protease 1(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294042BDBM294042(US10106557, Compound 8)
Affinity DataKi: >2.00E+4nMpH: 8.2Assay Description:The inhibitory activity on human trypsin was determined by using buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2). Appropriate wells in the Greiner 384 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetSerine protease 1(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294039BDBM294039(US10106557, Compound 1 | Process 1)
Affinity DataKi: >2.00E+4nMpH: 8.2Assay Description:The inhibitory activity on human trypsin was determined by using buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2). Appropriate wells in the Greiner 384 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetSerine protease 1(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294043BDBM294043(US10106557, Compound 30)
Affinity DataKi: >2.00E+4nMpH: 8.2Assay Description:The inhibitory activity on human trypsin was determined by using buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2). Appropriate wells in the Greiner 384 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetSerine protease 1(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 50024354BDBM50024354(CHEMBL3330444 | US10106557, Compound 2)
Affinity DataKi: >2.00E+4nMpH: 8.2Assay Description:The inhibitory activity on human trypsin was determined by using buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2). Appropriate wells in the Greiner 384 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetSerine protease 1(Human)
North China Pharmaceutical New Drug R&D

US Patent
LigandChemical structure of BindingDB Monomer ID 294041BDBM294041(US10106557, Compound 7)
Affinity DataKi: >2.00E+4nMpH: 8.2Assay Description:The inhibitory activity on human trypsin was determined by using buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2). Appropriate wells in the Greiner 384 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent