Compile Data Set for Download or QSAR
Report error Found 216 Enz. Inhib. hit(s) with all data for entry = 450
TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50204014(CHEMBL3944424 | US10059667, Example 27)
Affinity DataEC50:  0.300nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270333(US10059667, Example 54)
Affinity DataEC50:  0.600nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270289(US10059667, Example 10)
Affinity DataEC50:  0.900nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270310(US10059667, Example 31)
Affinity DataEC50:  1nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270304(US10059667, Example 25)
Affinity DataEC50:  1.40nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270305(US10059667, Example 26)
Affinity DataEC50:  1.5nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270279((2S,3R)-3-(3-(((S)-1-(2,5-bis(trifluoromethyl)benz...)
Affinity DataEC50:  1.90nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270286(US10059667, Example 7)
Affinity DataEC50:  2nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270288(US10059667, Example 9)
Affinity DataEC50:  4nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270312(US10059667, Example 33)
Affinity DataEC50:  5.30nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270340(US10059667, Example 62 | US10059667, Example 61)
Affinity DataEC50:  5.70nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270334(US10059667, Example 55)
Affinity DataEC50:  7.30nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270370(US10059667, Example 91)
Affinity DataEC50:  7.40nMAssay Description:The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 15,000 cells per well in growth medium (DMEM/10% f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270303(US10059667, Example 24)
Affinity DataEC50:  7.40nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50204014(CHEMBL3944424 | US10059667, Example 27)
Affinity DataEC50:  7.60nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270328(US10059667, Example 49)
Affinity DataEC50:  8.30nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270313(US10059667, Example 34)
Affinity DataEC50:  10nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270315(US10059667, Example 36)
Affinity DataEC50:  12nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270359(US10059667, Example 80)
Affinity DataEC50:  12nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270323(US10059667, Example 44)
Affinity DataEC50:  13nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270366(US10059667, Example 87)
Affinity DataEC50:  13nMAssay Description:The assay was performed in 384-well format. HEK cells stably expressing human GPR40 were plated at 15,000 cells per well in growth medium (DMEM/10% f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270300(US10059667, Example 21)
Affinity DataEC50:  13nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270317(US10059667, Example 38)
Affinity DataEC50:  13nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270363(US10059667, Example 84)
Affinity DataEC50:  14nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270342(US10059667, Example 63)
Affinity DataEC50:  15nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270287(US10059667, Example 8)
Affinity DataEC50:  15nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270314(US10059667, Example 35)
Affinity DataEC50:  20nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270307(US10059667, Example 28)
Affinity DataEC50:  21nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270344(US10059667, Example 65)
Affinity DataEC50:  22nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270290(US10059667, Example 11)
Affinity DataEC50:  22nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270366(US10059667, Example 87)
Affinity DataEC50:  23nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270320(US10059667, Example 41)
Affinity DataEC50:  23nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270335(US10059667, Example 56)
Affinity DataEC50:  23nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270340(US10059667, Example 62 | US10059667, Example 61)
Affinity DataEC50:  24nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270319(US10059667, Example 40)
Affinity DataEC50:  25nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270293(US10059667, Example 14)
Affinity DataEC50:  26nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270437(US10059667, Example 158)
Affinity DataEC50:  26nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270333(US10059667, Example 54)
Affinity DataEC50:  27nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270309(US10059667, Example 30)
Affinity DataEC50:  33nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270354(US10059667, Example 75)
Affinity DataEC50:  34nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270364(US10059667, Example 85)
Affinity DataEC50:  35nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270326(US10059667, Example 47)
Affinity DataEC50:  42nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270352(US10059667, Example 73)
Affinity DataEC50:  43nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270360(US10059667, Example 81)
Affinity DataEC50:  45nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270395(US10059667, Example 117 | US10059667, Example 116)
Affinity DataEC50:  50nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270279((2S,3R)-3-(3-(((S)-1-(2,5-bis(trifluoromethyl)benz...)
Affinity DataEC50:  51nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270385(US10059667, Example 106)
Affinity DataEC50:  54nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270305(US10059667, Example 26)
Affinity DataEC50:  55nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270329(US10059667, Example 50)
Affinity DataEC50:  55nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270353(US10059667, Example 74)
Affinity DataEC50:  56nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

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