Compile Data Set for Download or QSAR
Report error Found 376 Enz. Inhib. hit(s) with all data for entry = 9925
TargetTyrosine-protein kinase BTK [C481S](Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499813BDBM499813((2-chloro-4-phenoxyphenyl)(4- (((3R,6R)-6-(hydroxy...)
Affinity DataIC50: 0.370nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499811BDBM499811(US11020398, Compound I-123 | US20230364079, Exampl...)
Affinity DataIC50: 0.390nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 499813BDBM499813((2-chloro-4-phenoxyphenyl)(4- (((3R,6R)-6-(hydroxy...)
Affinity DataIC50: 0.560nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499813BDBM499813((2-chloro-4-phenoxyphenyl)(4- (((3R,6R)-6-(hydroxy...)
Affinity DataIC50: 0.560nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499810BDBM499810(N-((S)-1-((2S,5R)-5-((5-(2-chloro-4- phenoxybenzoy...)
Affinity DataIC50: 0.770nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499814BDBM499814((2-chloro-4-phenoxyphenyl)(4- (((3S,6S)-6-(hydroxy...)
Affinity DataIC50: 0.790nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499811BDBM499811(US11020398, Compound I-123 | US20230364079, Exampl...)
Affinity DataIC50: 0.850nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499811BDBM499811(US11020398, Compound I-123 | US20230364079, Exampl...)
Affinity DataIC50: 0.850nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499838BDBM499838((2-chloro-4-phenoxyphenyl)(4- (((3R,6S)-6-((R)-1- ...)
Affinity DataIC50: 0.930nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499924BDBM499924(N-(4-chloro-3-(4-(((3R,6S)-6- (hydroxymethyl)tetra...)
Affinity DataIC50: 0.980nMAssay Description:Purified full-length inactive BTK (wild type and C481 mutant, N-terminal 6XHIS tagged BTK, Mwt=78.2 kDa) were activated using soluble inositol hexaki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499976BDBM499976((racemic)-1-(2-(((5-(2-chloro-4- phenoxybenzoyl)-7...)
Affinity DataIC50: 0.980nMAssay Description:Purified full-length inactive BTK (wild type and C481 mutant, N-terminal 6XHIS tagged BTK, Mwt=78.2 kDa) were activated using soluble inositol hexaki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499869BDBM499869(N-(cis-4-((5-(2-chloro-4- phenoxybenzoyl)-7H-pyrro...)
Affinity DataIC50: 0.980nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499974BDBM499974((racemic)-1-(2-(((5-(2-chloro-4- phenoxybenzoyl)-7...)
Affinity DataIC50: 0.980nMAssay Description:Purified full-length inactive BTK (wild type and C481 mutant, N-terminal 6XHIS tagged BTK, Mwt=78.2 kDa) were activated using soluble inositol hexaki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499890BDBM499890((S)-2-hydroxy-N-(cis-4-((5-(4- phenoxybenzoyl)-7H-...)
Affinity DataIC50: 1nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499991BDBM499991(racemic-cis-(2-chloro-4- phenoxyphenyl)(4-(((6- (h...)
Affinity DataIC50: 1.07nMAssay Description:Purified full-length inactive BTK (wild type and C481 mutant, N-terminal 6XHIS tagged BTK, Mwt=78.2 kDa) were activated using soluble inositol hexaki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499892BDBM499892(N-((S)-1-((2S,5R)-5-((5-(2-methyl-4- phenoxybenzoy...)
Affinity DataIC50: 1.10nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499854BDBM499854((4-(((3R,6S)-6-((S)-1- aminoethyl)tetrahydro-2H-py...)
Affinity DataIC50: 1.10nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499881BDBM499881((S)-N-(cis-4-((5-(2-chloro-4- phenoxybenzoyl)-7H-p...)
Affinity DataIC50: 1.20nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499839BDBM499839(N-(cis-4-((5-(2-chloro-4- phenoxybenzoyl)-7H-pyrro...)
Affinity DataIC50: 1.30nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499891BDBM499891(2-hydroxy-2-methyl-N-(cis-4-((5-(4- phenoxybenzoyl...)
Affinity DataIC50: 1.40nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499888BDBM499888((2-chloro-4-phenoxyphenyl)(4-((cis-4- hydroxy-4-me...)
Affinity DataIC50: 1.40nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499855BDBM499855((2-chloro-4-phenoxyphenyl)(4- (((3R,6S)-6-((S)-1- ...)
Affinity DataIC50: 1.40nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499889BDBM499889((2-chloro-4-phenoxyphenyl)(4-((trans- 4-hydroxy-4-...)
Affinity DataIC50: 1.5nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499870BDBM499870((2-chloro-4-(3- fluorophenoxy)phenyl)(4-(((3R,6S)-...)
Affinity DataIC50: 1.5nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499882BDBM499882(N-(cis-4-((5-(2-chloro-4- phenoxybenzoyl)-7H-pyrro...)
Affinity DataIC50: 1.5nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499893BDBM499893(N-(((2S,5R)-5-((5-(4-phenoxybenzoyl)- 7H-pyrrolo[2...)
Affinity DataIC50: 1.60nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499885BDBM499885((4-(((3R,6S)-6-((R)-1- hydroxyethyl)tetrahydro-2H-...)
Affinity DataIC50: 1.60nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499815BDBM499815(N-(((2S,5R)-5-((5-(2-chloro-4- phenoxybenzoyl)-7H-...)
Affinity DataIC50: 1.63nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499876BDBM499876((2-chloro-4-phenoxyphenyl)(4- (((3R,6S)-6-(2-hydro...)
Affinity DataIC50: 1.70nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499857BDBM499857((2-chloro-4-phenoxyphenyl)(4-((trans- 4-hydroxycyc...)
Affinity DataIC50: 1.70nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499865BDBM499865((2-chloro-4-phenoxyphenyl)(4-((trans- 4-((dimethyl...)
Affinity DataIC50: 1.70nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499868BDBM499868(rac-(2-chloro-4-phenoxyphenyl)(4- (((1S,3R,4S)-3,4...)
Affinity DataIC50: 1.80nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499867BDBM499867(rac-(2-chloro-4-phenoxyphenyl)(4- (((1S,3S,4R)-3,4...)
Affinity DataIC50: 1.80nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499894BDBM499894((R)-2-hydroxy-N-(cis-4-((5-(4- phenoxybenzoyl)-7H-...)
Affinity DataIC50: 1.80nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499904BDBM499904((R)-N-(((2S,5R)-5-((5-(2-chloro-4- phenoxybenzoyl)...)
Affinity DataIC50: 1.90nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499790BDBM499790(N-(cis-4-((5-(2-chlorobenzoyl)-7H- pyrrolo[2,3-d]p...)
Affinity DataIC50: 1.90nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499739BDBM499739(1-(cis-4-((5-(2-chlorobenzoyl)-7H- pyrrolo[2,3-d]p...)
Affinity DataIC50: 1.90nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499898BDBM499898((S)-N-(((2S,5R)-5-((5-(2-chloro-4- phenoxybenzoyl)...)
Affinity DataIC50: 1.90nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499731BDBM499731((2-chlorophenyl)(4-((cis-4- (methylamino)cyclohexy...)
Affinity DataIC50: 2.10nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499829BDBM499829((4-((cis-4-aminocyclohexyl)amino)-7H- pyrrolo[2,3-...)
Affinity DataIC50: 2.20nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499871BDBM499871((2-chloro-4-(3- chlorophenoxy)phenyl)(4-(((3R,6S)-...)
Affinity DataIC50: 2.20nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499757BDBM499757((2-chlorophenyl)(4-((cis-4-(pyrrolidin- 1-yl)cyclo...)
Affinity DataIC50: 2.20nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499883BDBM499883(N-((R)-1-((2S,5R)-5-((5-(2-chloro-4- phenoxybenzoy...)
Affinity DataIC50: 2.20nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499866BDBM499866((2-chloro-4-phenoxyphenyl)(4-((cis-4- ((dimethylam...)
Affinity DataIC50: 2.20nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499827BDBM499827(N-(cis-4-((5-(4-phenoxybenzoyl)-7H- pyrrolo[2,3-d]...)
Affinity DataIC50: 2.30nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499773BDBM499773((S)-N-(cis-4-((5-(2-chlorobenzoyl)-7H- pyrrolo[2,3...)
Affinity DataIC50: 2.30nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499814BDBM499814((2-chloro-4-phenoxyphenyl)(4- (((3S,6S)-6-(hydroxy...)
Affinity DataIC50: 2.40nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499814BDBM499814((2-chloro-4-phenoxyphenyl)(4- (((3S,6S)-6-(hydroxy...)
Affinity DataIC50: 2.40nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499776BDBM499776((2-chlorophenyl)(4-((cis-4-(3- hydroxyazetidin-1- ...)
Affinity DataIC50: 2.5nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandChemical structure of BindingDB Monomer ID 499901BDBM499901((R)-N-((S)-1-((2S,5R)-5-((5-(2-chloro-4- phenoxybe...)
Affinity DataIC50: 2.5nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

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