Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 1319
TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316841(US9617260, Compound 2 | benzyl N-[3- [3-(prop-2- e...)
Affinity DataIC50: 0.300nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316842(US9617260, Compound 3 | propan-2-yl N- [3-[3-(prop...)
Affinity DataIC50: 0.300nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316873(US9617260, Compound 31 | benzyl N-[3- (1-prop-2- e...)
Affinity DataIC50: 0.600nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316875(US9617260, Compound 33 | benzyl N-[3- (1-prop-2- e...)
Affinity DataIC50: 0.600nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316872(US9617260, Compound 30 | benzyl N-[3- (1-prop-2- e...)
Affinity DataIC50: 1.20nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316876(US9617260, Compound 34 | benzyl N-[3- (3-hydroxy-1...)
Affinity DataIC50: 3.60nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316517(benzyl N-[3- [3-[[(E)-4- (dimethylamino) but-2- en...)
Affinity DataIC50: 7nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316843(US9617260, Compound 4 | benzyl N-[3- [3-(2- oxobut...)
Affinity DataIC50: 8nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316844(US9617260, Compound 5 | propan-2-yl N- [3-[3-[[(E)...)
Affinity DataIC50: 13nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316845(US9617260, Compound 6 | propan-2-yl N- [3-[3- [met...)
Affinity DataIC50: 24nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316874(US9617260, Compound 32 | propan-2-yl N- [3-(1-prop...)
Affinity DataIC50: 27nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316855(US9617260, Compound 14 | (2- chlorophenyl) methyl ...)
Affinity DataIC50: 30nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316857(US9617260, Compound 16 | (3- fluorophenyl) methyl ...)
Affinity DataIC50: 42nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316858(US9617260, Compound 17 | (3- fluorophenyl) methyl ...)
Affinity DataIC50: 43.7nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316847(US9617260, Compound 8 | propan-2-yl N- [3-[3-(2- o...)
Affinity DataIC50: 49nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316856(US9617260, Compound 15 | (2- chlorophenyl) methyl ...)
Affinity DataIC50: 60nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316850(US9617260, Compound 9 | benzyl N-[3- [3-[2- (trifl...)
Affinity DataIC50: 72nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316851(US9617260, Compound 10 | benzyl N-[3- [3-[(3,3- di...)
Affinity DataIC50: 100nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316860(US9617260, Compound 19 | (3- cyanophenyl) methyl N...)
Affinity DataIC50: 114nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316859(US9617260, Compound 18 | (3- fluorophenyl) methyl ...)
Affinity DataIC50: 123nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316861(US9617260, Compound 20 | (3- cyanophenyl) methyl N...)
Affinity DataIC50: 137nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316865(US9617260, Compound 24 | (2- chlorophenyl) methyl ...)
Affinity DataIC50: 165nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316852(US9617260, Compound 11 | benzyl N-[3- [3-[(3-methy...)
Affinity DataIC50: 206nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316870(US9617260, Compound 28 | (3- fluorophenyl) methyl ...)
Affinity DataIC50: 210nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316853(US9617260, Compound 12 | benzyl N-[3- [3-[(4-methy...)
Affinity DataIC50: 285nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316862(US9617260, Compound 21 | benzyl N-[3- [3-[(1- cyan...)
Affinity DataIC50: 287nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316868(US9617260, Compound 27 | benzyl N-[3- [1-(2- oxobu...)
Affinity DataIC50: 291nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316854(US9617260, Compound 13 | benzyl N-[3- [3-[(2-oxo-2...)
Affinity DataIC50: 323nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316864(US9617260, Compound 23 | benzyl N-[3- [2-[[(E)-4- ...)
Affinity DataIC50: 331nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316867(US9617260, Compound 26 | (3- fluorophenyl) methyl ...)
Affinity DataIC50: 384nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316866(US9617260, Compound 25 | (2- chlorophenyl) methyl ...)
Affinity DataIC50: 404nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316863(US9617260, Compound 22 | propan-2-yl N- [3-[3-[(2-...)
Affinity DataIC50: 620nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316871(US9617260, Compound 29 | (3- cyanophenyl) methyl N...)
Affinity DataIC50: 700nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM316846(US9617260, Compound 7 | propan-2-yl N- [3-[3-[3- m...)
Affinity DataIC50: 880nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluoresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent