Compile Data Set for Download or QSAR
Report error Found 213 Enz. Inhib. hit(s) with all data for entry = 1243
TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267123BDBM267123(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-...)
Affinity DataIC50: 8nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267120BDBM267120(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-[2-(t...)
Affinity DataIC50: 16nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267176BDBM267176(N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-oxazol-5-...)
Affinity DataIC50: 18nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267168BDBM267168(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(2-me...)
Affinity DataIC50: 18nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267170BDBM267170(N-[2-(4,4-difluoropiperidin-1-yl)-2-(2-methyl-1,3-...)
Affinity DataIC50: 18nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267223BDBM267223(2-chloro-N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl...)
Affinity DataIC50: 22nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267212BDBM267212(2-chloro-N-[2-(3,3-difluoropiperidin-1-yl)-2-(4-me...)
Affinity DataIC50: 22nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267201BDBM267201(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(2-me...)
Affinity DataIC50: 22nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267201BDBM267201(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(2-me...)
Affinity DataIC50: 24nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267121BDBM267121(N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-thiazol-5...)
Affinity DataIC50: 24nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267223BDBM267223(2-chloro-N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl...)
Affinity DataIC50: 26nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267121BDBM267121(N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-thiazol-5...)
Affinity DataIC50: 27nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267219BDBM267219(US9718812, 129 | US10167281, Compound 129)
Affinity DataIC50: 27nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267134BDBM267134(2-chloro-N-[2-(2-cyclopropyl-1,3-thiazol-5-yl)-2-(...)
Affinity DataIC50: 28nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267109BDBM267109(2-chloro-N-[2-(4,4-difluoro-piperidin-1-yl)-2-(1,3...)
Affinity DataIC50: 28nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267108BDBM267108((+)-2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(...)
Affinity DataIC50: 28nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267168BDBM267168(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(2-me...)
Affinity DataIC50: 28nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267170BDBM267170(N-[2-(4,4-difluoropiperidin-1-yl)-2-(2-methyl-1,3-...)
Affinity DataIC50: 30nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267108BDBM267108((+)-2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(...)
Affinity DataIC50: 30nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267133BDBM267133(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-...)
Affinity DataIC50: 30nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267102BDBM267102(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(4-me...)
Affinity DataIC50: 30nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267151BDBM267151(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(4-me...)
Affinity DataIC50: 31nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267135BDBM267135(N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-thiazol-5...)
Affinity DataIC50: 31nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267219BDBM267219(US9718812, 129 | US10167281, Compound 129)
Affinity DataIC50: 32nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267190BDBM267190(N-{2-[2-(4,4-difluorocyclohexyl)-1,3-thiazol-5-yl]...)
Affinity DataIC50: 32nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267125BDBM267125(5-amino-2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)...)
Affinity DataIC50: 32nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267156BDBM267156(N-{2-[2-(2,4-difluorophenyl)morpholin-4-yl]-2-(4-m...)
Affinity DataIC50: 32nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267098BDBM267098(N-[2-(4,4-difluoropiperidin-1-yl)-2-(4-methyl-1,3-...)
Affinity DataIC50: 32nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267163BDBM267163(2-chloro-N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl...)
Affinity DataIC50: 34nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267133BDBM267133(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-...)
Affinity DataIC50: 34nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267184BDBM267184(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-[2-(h...)
Affinity DataIC50: 36nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267178BDBM267178(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-...)
Affinity DataIC50: 36nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267134BDBM267134(2-chloro-N-[2-(2-cyclopropyl-1,3-thiazol-5-yl)-2-(...)
Affinity DataIC50: 36nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267149BDBM267149(2,6-dimethyl-N-[2-(4-methyl-1,3-thiazol-5-yl)-2-(1...)
Affinity DataIC50: 37nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267120BDBM267120(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-[2-(t...)
Affinity DataIC50: 38nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267123BDBM267123(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-...)
Affinity DataIC50: 38nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267210BDBM267210(2-chloro-N-[2-(3,3-difluoroazetidin-1-yl)-2-(4-met...)
Affinity DataIC50: 39nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267137BDBM267137(N-{2-[4-(benzyloxy)piperidin-1-yl]-2-(1,3-thiazol-...)
Affinity DataIC50: 40nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267192BDBM267192(2-chloro-N-{2-[2-(4,4-difluorocyclohexyl)-1,3-thia...)
Affinity DataIC50: 41nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267108BDBM267108((+)-2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(...)
Affinity DataIC50: 41nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267171BDBM267171(N-[2-(2-cyclobutyl-1,3-thiazol-5-yl)-2-(4,4-difluo...)
Affinity DataIC50: 42nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267141BDBM267141(N-{2-[4-(benzyloxy)piperidin-1-yl]-2-(1,3-thiazol-...)
Affinity DataIC50: 42nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267178BDBM267178(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-...)
Affinity DataIC50: 43nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267143BDBM267143(2,6-dimethyl-N-[2-(4-phenoxypiperidin-1-yl)-2-(1,3...)
Affinity DataIC50: 44nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267153BDBM267153(N-[2-(4,4-difluoropiperidin-1-yl)-2-(4-methyl-1,3-...)
Affinity DataIC50: 44nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267139BDBM267139(N-{2-[4-(benzyloxy)piperidin-1-yl]-2-(1,3-thiazol-...)
Affinity DataIC50: 44nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267149BDBM267149(2,6-dimethyl-N-[2-(4-methyl-1,3-thiazol-5-yl)-2-(1...)
Affinity DataIC50: 46nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267180BDBM267180(2-chloro-N-[2-(2-cyclobutyl-1,3-thiazol-5-yl)-2-(4...)
Affinity DataIC50: 46nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267141BDBM267141(N-{2-[4-(benzyloxy)piperidin-1-yl]-2-(1,3-thiazol-...)
Affinity DataIC50: 48nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandChemical structure of BindingDB Monomer ID 267128BDBM267128(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(2-et...)
Affinity DataIC50: 48nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

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