Compile Data Set for Download or QSAR
Report error Found 45 Enz. Inhib. hit(s) with all data for entry = 11297
TargetDNA-dependent protein kinase catalytic subunit(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605443BDBM605443(N-(2-chloro-5-(3-cyano-4-((1S- phenylethyl)amino)q...)
Affinity DataIC50: 2nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605270BDBM605270(US11673876, Comparative Compound 2)
Affinity DataIC50: 2nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 605452BDBM605452(N-(2-chloro-5-(4-((1S-(4- fluorophenyl)ethyl)amino...)
Affinity DataIC50: 2nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 605443BDBM605443(N-(2-chloro-5-(3-cyano-4-((1S- phenylethyl)amino)q...)
Affinity DataIC50: 2nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 605270BDBM605270(US11673876, Comparative Compound 2)
Affinity DataIC50: 2nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605238BDBM605238(US11673876, Comparative Compound 1)
Affinity DataIC50: 2nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605452BDBM605452(N-(2-chloro-5-(4-((1S-(4- fluorophenyl)ethyl)amino...)
Affinity DataIC50: 2nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605440BDBM605440(N-(2-chloro-5-(4-((1S- phenylethyl)amino)quinazoli...)
Affinity DataIC50: 2nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 605440BDBM605440(N-(2-chloro-5-(4-((1S- phenylethyl)amino)quinazoli...)
Affinity DataIC50: 2nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605450BDBM605450(N-(2-chloro-5-(3-cyano-4-((1-(4- fluorophenyl)ethy...)
Affinity DataIC50: 2nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 605238BDBM605238(US11673876, Comparative Compound 1)
Affinity DataIC50: 2nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 605450BDBM605450(N-(2-chloro-5-(3-cyano-4-((1-(4- fluorophenyl)ethy...)
Affinity DataIC50: 2nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605270BDBM605270(US11673876, Comparative Compound 2)
Affinity DataIC50: 11nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 605451BDBM605451(N-(2-chloro-5-(4-((1R-(4- fluorophenyl)ethyl)amino...)
Affinity DataIC50: 11nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605439BDBM605439(N-(2-chloro-5-(4-((1R- phenylethyl)amino)quinazoli...)
Affinity DataIC50: 11nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605453BDBM605453(6-(2-aminopyrimidin-5-yl)-N-(1-(4- fluorophenyl)et...)
Affinity DataIC50: 11nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 605439BDBM605439(N-(2-chloro-5-(4-((1R- phenylethyl)amino)quinazoli...)
Affinity DataIC50: 11nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605454BDBM605454(6-(5-(5-oxo-4,5-dihydro-1,3,4-oxadiazol- 2-yl)pyri...)
Affinity DataIC50: 11nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605454BDBM605454(6-(5-(5-oxo-4,5-dihydro-1,3,4-oxadiazol- 2-yl)pyri...)
Affinity DataIC50: 11nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605439BDBM605439(N-(2-chloro-5-(4-((1R- phenylethyl)amino)quinazoli...)
Affinity DataIC50: 11nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 605442BDBM605442(N-(2-chloro-5-(3-cyano-4-((1R- phenylethyl)amino)q...)
Affinity DataIC50: 11nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605441BDBM605441(6-(5,6-dimethoxypyridin-3-yl)-N-(1- phenylethyl)qu...)
Affinity DataIC50: 11nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605442BDBM605442(N-(2-chloro-5-(3-cyano-4-((1R- phenylethyl)amino)q...)
Affinity DataIC50: 11nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605444BDBM605444(6-(2-aminopyrimidin-5-yl)-4-((1- phenylethyl)amino...)
Affinity DataIC50: 11nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605449BDBM605449(4-((1-phenylethyl)amino)-6-(1H- pyrazolo[3,4-b]pyr...)
Affinity DataIC50: 11nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605445BDBM605445((R)-6-(2-aminopyrimidin-5-yl)-4-((1- phenylethyl)a...)
Affinity DataIC50: 11nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605449BDBM605449(4-((1-phenylethyl)amino)-6-(1H- pyrazolo[3,4-b]pyr...)
Affinity DataIC50: 11nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605451BDBM605451(N-(2-chloro-5-(4-((1R-(4- fluorophenyl)ethyl)amino...)
Affinity DataIC50: 110nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605444BDBM605444(6-(2-aminopyrimidin-5-yl)-4-((1- phenylethyl)amino...)
Affinity DataIC50: 110nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605438BDBM605438(US11673876, Comparative Compound 3)
Affinity DataIC50: 110nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 605438BDBM605438(US11673876, Comparative Compound 3)
Affinity DataIC50: 110nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605445BDBM605445((R)-6-(2-aminopyrimidin-5-yl)-4-((1- phenylethyl)a...)
Affinity DataIC50: 110nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 605454BDBM605454(6-(5-(5-oxo-4,5-dihydro-1,3,4-oxadiazol- 2-yl)pyri...)
Affinity DataIC50: 110nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605238BDBM605238(US11673876, Comparative Compound 1)
Affinity DataIC50: 110nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 605441BDBM605441(6-(5,6-dimethoxypyridin-3-yl)-N-(1- phenylethyl)qu...)
Affinity DataIC50: 110nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605452BDBM605452(N-(2-chloro-5-(4-((1S-(4- fluorophenyl)ethyl)amino...)
Affinity DataIC50: 200nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605443BDBM605443(N-(2-chloro-5-(3-cyano-4-((1S- phenylethyl)amino)q...)
Affinity DataIC50: 200nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605453BDBM605453(6-(2-aminopyrimidin-5-yl)-N-(1-(4- fluorophenyl)et...)
Affinity DataIC50: 200nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 605445BDBM605445((R)-6-(2-aminopyrimidin-5-yl)-4-((1- phenylethyl)a...)
Affinity DataIC50: 200nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 605453BDBM605453(6-(2-aminopyrimidin-5-yl)-N-(1-(4- fluorophenyl)et...)
Affinity DataIC50: 200nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 605444BDBM605444(6-(2-aminopyrimidin-5-yl)-4-((1- phenylethyl)amino...)
Affinity DataIC50: 200nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 605449BDBM605449(4-((1-phenylethyl)amino)-6-(1H- pyrazolo[3,4-b]pyr...)
Affinity DataIC50: 200nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605440BDBM605440(N-(2-chloro-5-(4-((1S- phenylethyl)amino)quinazoli...)
Affinity DataIC50: 200nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605450BDBM605450(N-(2-chloro-5-(3-cyano-4-((1-(4- fluorophenyl)ethy...)
Affinity DataIC50: 200nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Mekanistic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605441BDBM605441(6-(5,6-dimethoxypyridin-3-yl)-N-(1- phenylethyl)qu...)
Affinity DataIC50: 200nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
US Patent