Compile Data Set for Download or QSAR
Report error Found 63 Enz. Inhib. hit(s) with all data for entry = 553
TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278409BDBM278409((2S)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-...)
Affinity DataIC50: 14.8nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278400BDBM278400(US10040788, Example 2(a) | (2S)-2-Methoxy-2-phenyl...)
Affinity DataIC50: 15.3nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278400BDBM278400(US10040788, Example 2(a) | (2S)-2-Methoxy-2-phenyl...)
Affinity DataIC50: 16.2nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278413BDBM278413((2S)-2-Methoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrroli...)
Affinity DataIC50: 18.6nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278450BDBM278450(US10040788, Example 30(b))
Affinity DataIC50: 21nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278400BDBM278400(US10040788, Example 2(a) | (2S)-2-Methoxy-2-phenyl...)
Affinity DataIC50: 21.3nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278405BDBM278405((2S)-2-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-p...)
Affinity DataIC50: 21.5nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278418BDBM278418((2S)-2-(4-Fluorophenyl)-2-methoxy-N-[5-[[(3R)-1-py...)
Affinity DataIC50: 22nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278422BDBM278422((2S)-2-(4-Fluoro-3-methoxy-phenyl)-2-methoxy-N-[5-...)
Affinity DataIC50: 25.5nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278420BDBM278420(US10040788, Example 13(b) | (2S)-2-Ethoxy-2-(4-flu...)
Affinity DataIC50: 27nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278410BDBM278410((2R)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-...)
Affinity DataIC50: 27.1nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278415BDBM278415((2S)-2-Ethoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-y...)
Affinity DataIC50: 27.6nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278436BDBM278436(US10040788, Example 23(a) | US10294221, Example 23...)
Affinity DataIC50: 27.6nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50172181BDBM50172181(CHEMBL3810394 | US10040788, Example 3 | US10294221...)
Affinity DataIC50: 29nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278411BDBM278411((2S)-2-Methoxy-N-[5-[[(3R)-1-(1,2,4-triazin-3-yl)p...)
Affinity DataIC50: 30.6nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50172239BDBM50172239(CHEMBL3809014 | US10040788, Example 11 | US1029422...)
Affinity DataIC50: 31nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278414BDBM278414((2R)-2-Methoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrroli...)
Affinity DataIC50: 32.9nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278445BDBM278445(US10040788, Example 28(a) | US10294221, Example 28...)
Affinity DataIC50: 34.1nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278439BDBM278439(US10040788, Example 25(a) | US10294221, Example 25...)
Affinity DataIC50: 35.4nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278403BDBM278403((2S)-2-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-(...)
Affinity DataIC50: 35.5nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278435BDBM278435(US10040788, Example 22(b))
Affinity DataIC50: 43.4nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278433BDBM278433(US10040788, Example 21(b))
Affinity DataIC50: 46.9nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278451BDBM278451(US10040788, Example 31(a) | US10294221, Example 31...)
Affinity DataIC50: 50.2nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278455BDBM278455(US10040788, Example 33(a) | US10294221, Example 33...)
Affinity DataIC50: 50.2nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278443BDBM278443(US10040788, Example 27(a) | US10294221, Example 27...)
Affinity DataIC50: 50.8nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50172138BDBM50172138(CHEMBL3808443 | US10040788, Example 1(a) | US10294...)
Affinity DataIC50: 62.8nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278454BDBM278454(US10040788, Example 32(b))
Affinity DataIC50: 70.7nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278434BDBM278434(US10040788, Example 22(a) | US10294221, Example 22...)
Affinity DataIC50: 72.9nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278438BDBM278438((2S)-2-methoxy-2-(4- methoxyphenyl)-N-[5-[[(3R)- 1...)
Affinity DataIC50: 74.7nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278446BDBM278446(US10040788, Example 28(b))
Affinity DataIC50: 84.8nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278407BDBM278407(US10040788, Example 6(a) | BDBM278428 | (2S)-2-[3-...)
Affinity DataIC50: 85.1nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278407BDBM278407(US10040788, Example 6(a) | BDBM278428 | (2S)-2-[3-...)
Affinity DataIC50: 85.1nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278452BDBM278452(US10040788, Example 31(b))
Affinity DataIC50: 86.2nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278442BDBM278442(US10040788, Example 26(b))
Affinity DataIC50: 87.7nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278406BDBM278406((2R)-2-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-p...)
Affinity DataIC50: 87.9nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278457BDBM278457(US10040788, Example 34(a) | US10294221, Example 34...)
Affinity DataIC50: 88.1nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278425BDBM278425(US10040788, Example 17(b) | US10294221, Example 17...)
Affinity DataIC50: 92.6nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278449BDBM278449(US10040788, Example 30(a) | US10294221, Example 30...)
Affinity DataIC50: 92.8nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278418BDBM278418((2S)-2-(4-Fluorophenyl)-2-methoxy-N-[5-[[(3R)-1-py...)
Affinity DataIC50: 102nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278427BDBM278427(US10040788, Example 20(b) | US10040788, Example 18...)
Affinity DataIC50: 107nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278447BDBM278447(US10040788, Example 29(a) | US10294221, Example 29...)
Affinity DataIC50: 108nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278416BDBM278416((2R)-2-Ethoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-y...)
Affinity DataIC50: 110nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278427BDBM278427(US10040788, Example 20(b) | US10040788, Example 18...)
Affinity DataIC50: 119nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278440BDBM278440(US10040788, Example 25(b))
Affinity DataIC50: 135nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278401BDBM278401((2R)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...)
Affinity DataIC50: 147nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278460BDBM278460(US10040788, Example 35(b) | US10294221, Example 35...)
Affinity DataIC50: 155nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278432BDBM278432(US10040788, Example 21(a) | US10294221, Example 21...)
Affinity DataIC50: 162nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278437BDBM278437(US10040788, Example 23(b))
Affinity DataIC50: 162nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278423BDBM278423((2R)-2-(4-Fluoro-3-methoxy-phenyl)-2-methoxy-N-[5-...)
Affinity DataIC50: 168nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 278420BDBM278420(US10040788, Example 13(b) | (2S)-2-Ethoxy-2-(4-flu...)
Affinity DataIC50: 170nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

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