Compile Data Set for Download or QSAR
Report error Found 123 Enz. Inhib. hit(s) with all data for entry = 6228
TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118233BDBM118233(US8673966, tert-butyl (1-(3-((3-(4-(methylsulfonam...)
Affinity DataIC50: 2.30nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118229BDBM118229(US8673966, N-(4-(7-((1-(cyclobutanecarbonyl)azetid...)
Affinity DataIC50: 4nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118196BDBM118196(US8673966, N-(4-(7-((1-methyl-1H-imidazol-5-yl)eth...)
Affinity DataIC50: 4.90nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118228BDBM118228(US8673966, N-(4-(7-((1-(2,2-difluorocyclopropane- ...)
Affinity DataIC50: 5nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118232BDBM118232(US8673966, tert-butyl 1-(3-((3-(4- (methylsulfonam...)
Affinity DataIC50: 5nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118223BDBM118223(US8673966, N-(4-(7-((1-(3-hydroxy-3-methylcyclobut...)
Affinity DataIC50: 5nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118209BDBM118209(US8673966, N-(4-(7-((1-(cyclopropanecarbonyl)azeti...)
Affinity DataIC50: 5nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118231BDBM118231(US8673966, tert-butyl 1-(3-((3-(4-(methylsulfonami...)
Affinity DataIC50: 6nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118230BDBM118230(US8673966, N-(4-(7-((1-(1-methylcyclopropanecarbon...)
Affinity DataIC50: 6nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118220BDBM118220(US8673966, N-(4-(7-((1-(3,3-difluorocyclobutanecar...)
Affinity DataIC50: 6nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118225BDBM118225(US8673966, N-(4-(7-((1-(3-methyloxetane-3- carbony...)
Affinity DataIC50: 6nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118211BDBM118211(US8673966, N-(4-(7-((1-(cyclopropanecarbonyl)piper...)
Affinity DataIC50: 6.5nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118213BDBM118213(US8673966, N-(4-(7-((1-isopropyl-1H-imidazol-5- yl...)
Affinity DataIC50: 7nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118219BDBM118219(US8673966, N-(4-(7-((1-(3-methoxypropanoyl)azetidi...)
Affinity DataIC50: 8nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118216BDBM118216(US8673966, cyclopentyl 3-((3-(4- (methylsulfonamid...)
Affinity DataIC50: 9nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118207BDBM118207(US8673966, tert-butyl 3-((3-(4-(methylsulfonamido)...)
Affinity DataIC50: 9nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118208BDBM118208(US8673966, N-(4-(4-oxo-7-((2-oxo-1,2-dihydropyridi...)
Affinity DataIC50: 9nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118212BDBM118212(US8673966, N-(4-(7-((1,2-dimethyl-1H-imidazol-5- y...)
Affinity DataIC50: 15nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118222BDBM118222(US8673966, N-(4-(7-((1-(2-hydroxyacetyl)azetidin-3...)
Affinity DataIC50: 15nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118226BDBM118226(US8673966, N-(4-(7-((1-(2-hydroxypropanoyl)azetidi...)
Affinity DataIC50: 15nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118224BDBM118224(US8673966, N-(4-(7-((1-(2-hydroxy-2-methylpropanoy...)
Affinity DataIC50: 16nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118203BDBM118203(US8673966, N-(4-(4-oxo-7-(pyridin-3-ylethynyl)-4H-...)
Affinity DataIC50: 21nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118227BDBM118227(US8673966, N-(4-(7-((1-(1-methylpiperidine-4- carb...)
Affinity DataIC50: 35nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118217BDBM118217(US8673966, N-(4-(4-oxo-7-((tetrahydro-2H-pyran-4- ...)
Affinity DataIC50: 43nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118197BDBM118197(US8673966, N-(4-(7-(3-methoxyprop-1-ynyl)-4-oxo-4H...)
Affinity DataIC50: 47nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118202BDBM118202(US8673966, N-(4-(4-oxo-7-(pyrimidin-5-ylethynyl)-4...)
Affinity DataIC50: 57nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118193BDBM118193(US8673966, N-(4-(7-(cyclopropylethynyl)-4-oxo-4H- ...)
Affinity DataIC50: 57.7nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118221BDBM118221(US8673966, N-(4-(7-((1-(3-(dimethylamino)propanoyl...)
Affinity DataIC50: 64nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118206BDBM118206(US8673966, tert-butyl 4-((3-(4-(methylsulfonamido)...)
Affinity DataIC50: 86nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118200BDBM118200(US8673966, N-(4-(4-oxo-7-(pyridin-2-ylethynyl)-4H-...)
Affinity DataIC50: 90nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118214BDBM118214(US8673966, N-(4-(7-((1-methyl-1H-imidazol-4-yl)eth...)
Affinity DataIC50: 95nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118204BDBM118204(US8673966, N-(4-(7-(3-methoxyprop-1-ynyl)-4-oxo-4H...)
Affinity DataIC50: 96nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118218BDBM118218(US8673966, N-(4-(7-((1-isobutylazetidin-3-yl)ethyn...)
Affinity DataIC50: 109nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118205BDBM118205(US8673966, N-(4-(7-((1-hydroxycyclopentyl)ethynyl)...)
Affinity DataIC50: 156nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118210BDBM118210(US8673966, N-(4-(4-oxo-7-(piperidin-4-ylethynyl)-4...)
Affinity DataIC50: 174nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118215BDBM118215(US8673966, N-(4-(7-(azetidin-3-ylethynyl)-4-oxo-4H...)
Affinity DataIC50: 266nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118194BDBM118194(US8673966, N-(4-(4-oxo-7-(phenylethynyl)-4H-chrome...)
Affinity DataIC50: 329nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118196BDBM118196(US8673966, N-(4-(7-((1-methyl-1H-imidazol-5-yl)eth...)
Affinity DataIC50: 365nMpH: 7.5Assay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118201BDBM118201(US8673966, N-(4-(7-((1-hydroxycyclopentyl)ethynyl)...)
Affinity DataIC50: 386nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118199BDBM118199(US8673966, N-(4-(7-((1-aminocyclohexyl)ethynyl)-4-...)
Affinity DataIC50: 528nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118198BDBM118198(US8673966, N-(4-(7-((1-hydroxycyclohexyl)ethynyl)-...)
Affinity DataIC50: 1.71E+3nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118195BDBM118195(US8673966, N-(4-(7-(3-hydroxy-3-methylbut-1-ynyl)-...)
Affinity DataIC50: 2.18E+3nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118194BDBM118194(US8673966, N-(4-(4-oxo-7-(phenylethynyl)-4H-chrome...)
Affinity DataIC50: 1.30E+4nMpH: 7.5Assay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] A(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118194BDBM118194(US8673966, N-(4-(4-oxo-7-(phenylethynyl)-4H-chrome...)
Affinity DataIC50: 1.30E+4nMpH: 7.5Assay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] A(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118193BDBM118193(US8673966, N-(4-(7-(cyclopropylethynyl)-4-oxo-4H- ...)
Affinity DataIC50: 1.30E+4nMpH: 7.5Assay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118193BDBM118193(US8673966, N-(4-(7-(cyclopropylethynyl)-4-oxo-4H- ...)
Affinity DataIC50: 1.30E+4nMpH: 7.5Assay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] A(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118221BDBM118221(US8673966, N-(4-(7-((1-(3-(dimethylamino)propanoyl...)
Affinity DataIC50: 4.69E+4nMpH: 7.5Assay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] A(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118214BDBM118214(US8673966, N-(4-(7-((1-methyl-1H-imidazol-4-yl)eth...)
Affinity DataIC50: 8.65E+4nMpH: 7.5Assay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118195BDBM118195(US8673966, N-(4-(7-(3-hydroxy-3-methylbut-1-ynyl)-...)
Affinity DataIC50: 9.10E+4nMpH: 7.5Assay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] A(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118195BDBM118195(US8673966, N-(4-(7-(3-hydroxy-3-methylbut-1-ynyl)-...)
Affinity DataIC50: 9.10E+4nMpH: 7.5Assay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

Displayed 1 to 50 (of 123 total ) | Next | Last >>
Jump to: