Compile Data Set for Download or QSAR
Report error Found 82 Enz. Inhib. hit(s) with all data for entry = 11222
TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM601403(US11634410, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)
Affinity DataIC50: 1.5nMAssay Description:Using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319583(US10174007, Example 2 | US10787438, Example 2 | US...)
Affinity DataIC50: 1.5nMAssay Description:Using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)
Affinity DataIC50: 1.5nMAssay Description:Using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319602([(1R,5S,6R)-3-{5-methyl-2-[(2S)-2-methylazetidin-1...)
Affinity DataIC50: 2.40nMAssay Description:Using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM601403(US11634410, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)
Affinity DataIC50: 2.60nMAssay Description:Assay C was performed at high fructose and ATP concentrations, conditions that would be more consistent with physiological concentrations of the natu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319600([(1R,5S,6R)-3-{2-[(2S,3R)-3-hydroxy-2-methylazetid...)
Affinity DataIC50: 3.30nMAssay Description:Using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)
Affinity DataIC50: 3.30nMAssay Description:Assay C was performed at high fructose and ATP concentrations, conditions that would be more consistent with physiological concentrations of the natu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319583(US10174007, Example 2 | US10787438, Example 2 | US...)
Affinity DataIC50: 3.60nMAssay Description:Assay C was performed at high fructose and ATP concentrations, conditions that would be more consistent with physiological concentrations of the natu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319601([(1R,5S,6R)-3-{5-chloro-6-(difluoromethyl)-2-[(2S)...)
Affinity DataIC50: 3.70nMAssay Description:Using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM601403(US11634410, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)
Affinity DataIC50: 4.40nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM601403(US11634410, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)
Affinity DataIC50: 4.40nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)
Affinity DataIC50: 5.5nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM601406(US11634410, Example 16 | [(1R,5S,6R)-3-{5-chloro-2...)
Affinity DataIC50: 6.40nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319583(US10174007, Example 2 | US10787438, Example 2 | US...)
Affinity DataIC50: 6.80nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM601409(US11634410, Example 19 | [(1R,5S,6R)-3-{5-cyano-4-...)
Affinity DataIC50: 7.20nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)
Affinity DataIC50: 7.30nMAssay Description:Assay D was performed using human KHK-A to assess the potency of compounds in inhibiting activity of this enzyme. Compounds were prepared in DMSO as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319603([(1R,5S,6R)-3-{6-(difluoromethyl)-5-methyl-2-[(2S)...)
Affinity DataIC50: 8nMAssay Description:Using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319585(US10174007, Example 4 | US10787438, Example 4 | US...)
Affinity DataIC50: 8.40nMAssay Description:Using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM601411(US11634410, Example 36 | [(1R,5S,6R)-3-{3-chloro-5...)
Affinity DataIC50: 8.70nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319602([(1R,5S,6R)-3-{5-methyl-2-[(2S)-2-methylazetidin-1...)
Affinity DataIC50: 8.80nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319602([(1R,5S,6R)-3-{5-methyl-2-[(2S)-2-methylazetidin-1...)
Affinity DataIC50: 8.80nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319600([(1R,5S,6R)-3-{2-[(2S,3R)-3-hydroxy-2-methylazetid...)
Affinity DataIC50: 9.70nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319600([(1R,5S,6R)-3-{2-[(2S,3R)-3-hydroxy-2-methylazetid...)
Affinity DataIC50: 9.70nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319602([(1R,5S,6R)-3-{5-methyl-2-[(2S)-2-methylazetidin-1...)
Affinity DataIC50: 10.5nMAssay Description:Assay D was performed using human KHK-A to assess the potency of compounds in inhibiting activity of this enzyme. Compounds were prepared in DMSO as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319600([(1R,5S,6R)-3-{2-[(2S,3R)-3-hydroxy-2-methylazetid...)
Affinity DataIC50: 11nMAssay Description:Assay C was performed at high fructose and ATP concentrations, conditions that would be more consistent with physiological concentrations of the natu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319601([(1R,5S,6R)-3-{5-chloro-6-(difluoromethyl)-2-[(2S)...)
Affinity DataIC50: 11.1nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319601([(1R,5S,6R)-3-{5-chloro-6-(difluoromethyl)-2-[(2S)...)
Affinity DataIC50: 11.1nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM601413(US11634410, Example 23 | [(1R,5S,6R)-3-{5-cyano-6-...)
Affinity DataIC50: 11.6nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319600([(1R,5S,6R)-3-{2-[(2S,3R)-3-hydroxy-2-methylazetid...)
Affinity DataIC50: 12.1nMAssay Description:Assay D was performed using human KHK-A to assess the potency of compounds in inhibiting activity of this enzyme. Compounds were prepared in DMSO as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319586(US10174007, Example 5 | US10787438, Example 5 | US...)
Affinity DataIC50: 13.6nMAssay Description:Using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM601444(US11634410, Example 55 | [(1R,5S,6R)-3-{5-cyano-4-...)
Affinity DataIC50: 13.7nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319585(US10174007, Example 4 | US10787438, Example 4 | US...)
Affinity DataIC50: 14.2nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM494878(US10988463, Example 12 | US11634410, Example 18)
Affinity DataIC50: 16.7nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319603([(1R,5S,6R)-3-{6-(difluoromethyl)-5-methyl-2-[(2S)...)
Affinity DataIC50: 17.8nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319603([(1R,5S,6R)-3-{6-(difluoromethyl)-5-methyl-2-[(2S)...)
Affinity DataIC50: 17.8nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM601443(US11634410, Example 54 | [(1R,5S,6R)-3-{5-cyano-4-...)
Affinity DataIC50: 19nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM601405(US11634410, Example 15 | [(1R,5S,6R)-3-{5-chloro-6...)
Affinity DataIC50: 19.1nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM601442(US11634410, Example 53 | [(1R,5S,6R)-3-{5-cyano-2-...)
Affinity DataIC50: 21nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM601436(US11634410, Example 46 | {(1R,5S,6s)-3-[6-(azetidi...)
Affinity DataIC50: 21.5nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319586(US10174007, Example 5 | US10787438, Example 5 | US...)
Affinity DataIC50: 24.7nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM601432(US11634410, Example 39 | {(1R,5S,6s)-3-[2-(2- (tri...)
Affinity DataIC50: 24.8nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM601430(US11634410, Example 38 | {(1R,5S,6s)-3-[5-cyano-4-...)
Affinity DataIC50: 25.3nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM601423(US11634410, Example 31 | {(1R,5S,6s)-3-[5-cyano-6-...)
Affinity DataIC50: 30nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM601410(US11634410, Example 20 | [(1R,5S,6R)-3-{6- hydroxy...)
Affinity DataIC50: 33.4nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319598(US10174007, Example 13 | US10787438, Example 13 | ...)
Affinity DataIC50: 33.9nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319585(US10174007, Example 4 | US10787438, Example 4 | US...)
Affinity DataIC50: 37.3nMAssay Description:Assay C was performed at high fructose and ATP concentrations, conditions that would be more consistent with physiological concentrations of the natu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319601([(1R,5S,6R)-3-{5-chloro-6-(difluoromethyl)-2-[(2S)...)
Affinity DataIC50: 37.9nMAssay Description:Assay D was performed using human KHK-A to assess the potency of compounds in inhibiting activity of this enzyme. Compounds were prepared in DMSO as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319603([(1R,5S,6R)-3-{6-(difluoromethyl)-5-methyl-2-[(2S)...)
Affinity DataIC50: 48.6nMAssay Description:Assay D was performed using human KHK-A to assess the potency of compounds in inhibiting activity of this enzyme. Compounds were prepared in DMSO as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM601434(US11634410, Example 44 | [(1R,5S,6R)-3-(6-(1,1- [(...)
Affinity DataIC50: 51.4nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM319589(US10174007, Example 8 | US10787438, Example 8 | US...)
Affinity DataIC50: 53.8nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

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