Compile Data Set for Download or QSAR
Report error Found 117 Enz. Inhib. hit(s) with all data for entry = 11324
TargetTransmembrane prolyl 4-hydroxylase(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 4nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTransmembrane prolyl 4-hydroxylase(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511474(US11059789, Example 23 | US11691950, Example 23)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTransmembrane prolyl 4-hydroxylase(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511485(US11059789, Example 27 | US11691950, Example 27)
Affinity DataIC50: 6nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511482(US11059789, Example 83 | US11691950, Example 83)
Affinity DataIC50: 9nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTransmembrane prolyl 4-hydroxylase(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511480(US11059789, Example 40 | US11691950, Example 40)
Affinity DataIC50: 11nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511482(US11059789, Example 83 | US11691950, Example 83)
Affinity DataIC50: 11nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511485(US11059789, Example 27 | US11691950, Example 27)
Affinity DataIC50: 13nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511480(US11059789, Example 40 | US11691950, Example 40)
Affinity DataIC50: 13nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 14nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTransmembrane prolyl 4-hydroxylase(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511483(US11059789, Example 66 | US11691950, Example 66)
Affinity DataIC50: 15nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511476(US11059789, Example 28 | US11691950, Example 28)
Affinity DataIC50: 15.5nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 17nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511480(US11059789, Example 40 | US11691950, Example 40)
Affinity DataIC50: 19nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 21nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 25nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTransmembrane prolyl 4-hydroxylase(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511482(US11059789, Example 83 | US11691950, Example 83)
Affinity DataIC50: 25nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511483(US11059789, Example 66 | US11691950, Example 66)
Affinity DataIC50: 26nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 27nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511480(US11059789, Example 40 | US11691950, Example 40)
Affinity DataIC50: 28nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511485(US11059789, Example 27 | US11691950, Example 27)
Affinity DataIC50: 29nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511482(US11059789, Example 83 | US11691950, Example 83)
Affinity DataIC50: 29nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511483(US11059789, Example 66 | US11691950, Example 66)
Affinity DataIC50: 36nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 39nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetProtein kinase C eta type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511482(US11059789, Example 83 | US11691950, Example 83)
Affinity DataIC50: 51nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511483(US11059789, Example 66 | US11691950, Example 66)
Affinity DataIC50: 55nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511482(US11059789, Example 83 | US11691950, Example 83)
Affinity DataIC50: 55nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetProtein kinase C delta type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511482(US11059789, Example 83 | US11691950, Example 83)
Affinity DataIC50: 56nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 58nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511477(US11059789, Example 29 | US11691950, Example 29)
Affinity DataIC50: 71nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511480(US11059789, Example 40 | US11691950, Example 40)
Affinity DataIC50: 71nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 81nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511468(US11059789, Example 12 | US11691950, Example 12)
Affinity DataIC50: 90.5nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511482(US11059789, Example 83 | US11691950, Example 83)
Affinity DataIC50: 95nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511470(US11059789, Example 91 | US11691950, Example 91)
Affinity DataIC50: 102nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 103nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511483(US11059789, Example 66 | US11691950, Example 66)
Affinity DataIC50: 117nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 138nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetProtein kinase C delta type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 142nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511472(US11059789, Example 20 | US11691950, Example 20)
Affinity DataIC50: 144nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetProtein kinase C eta type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50: 145nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetProtein kinase C delta type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511480(US11059789, Example 40 | US11691950, Example 40)
Affinity DataIC50: 152nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetProtein kinase C epsilon type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511482(US11059789, Example 83 | US11691950, Example 83)
Affinity DataIC50: 154nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetProtein kinase C eta type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 173nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetProtein kinase C eta type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511480(US11059789, Example 40 | US11691950, Example 40)
Affinity DataIC50: 190nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetProtein kinase C delta type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 225nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511475(US11059789, Example 26 | US11691950, Example 26)
Affinity DataIC50: 227nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511466(US11059789, Example 4 | US11691950, Example 4)
Affinity DataIC50: 230nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetProtein kinase C epsilon type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511480(US11059789, Example 40 | US11691950, Example 40)
Affinity DataIC50: 244nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetProtein kinase C eta type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511483(US11059789, Example 66 | US11691950, Example 66)
Affinity DataIC50: 282nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

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