Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 8671
TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412253(US10399939, Example 132 | (5R,6S)-5-(4-((1-(3- flu...)
Affinity DataEC50:  0.0290nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412241(US10399939, Example 120 | (5S,6S)-5-(2-fluoro-4- (...)
Affinity DataEC50:  0.0360nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412245(US10399939, Example 124 | (5S,6R)-5-(4-((S)-2- ((R...)
Affinity DataEC50:  0.0370nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412255(US10399939, Example 134 | 4-((1S,2R)-1-(4-(2-(3- (...)
Affinity DataEC50:  0.0380nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412225(US10399939, Example 105 | (1S,2S)-1-[2,6- difluoro...)
Affinity DataEC50:  0.0400nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412248(US10399939, Example 127 | (5S,6S)-5-(6-(2-(3- (flu...)
Affinity DataEC50:  0.0460nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412235(US10399939, Example 114 | (5S,6R)-5-(4-(2-(3- (flu...)
Affinity DataEC50:  0.100nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412251(US10399939, Example 130 | (5R,6S)-5-(4-((1-(3- flu...)
Affinity DataEC50:  0.107nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412230(US10399939, Example 109 | (5S,6S)-5-(4-(2-(3- (flu...)
Affinity DataEC50:  0.164nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412234(US10399939, Example 113 | (5S,6R)-5-(4-(2-(3- (chl...)
Affinity DataEC50:  0.177nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412231(US10399939, Example 110 | (5R,6R)-6-(4,4- difluoro...)
Affinity DataEC50:  0.177nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412239(US10399939, Example 118 | (5R,6S)-5-(4-(2-(3- (dif...)
Affinity DataEC50:  0.184nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412259(US10399939, Example 138 | (5S,6R)-5-(4-((2-(3- (fl...)
Affinity DataEC50:  0.203nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412242(US10399939, Example 121 | (S)-1'-(4-(2-(3- (fluoro...)
Affinity DataEC50:  0.208nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412238(US10399939, Example 117 | (5R,6S)-5-(4-(2-(3- (flu...)
Affinity DataEC50:  0.227nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412221(US10399939, Example 101 | (1R,2S)-1-[4-[2-[3- (flu...)
Affinity DataEC50:  0.371nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412243(US10399939, Example 122 | (R)-1'-(4-(2-(3- (fluoro...)
Affinity DataEC50:  0.451nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412247(US10399939, Example 126 | (5S,6R)-5-(4-(((R)-1- ((...)
Affinity DataEC50:  0.675nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412261(US10399939, Example 140 | (5S,6R)-5-(4-((2-((R)- 3...)
Affinity DataEC50:  0.773nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412226(US10399939, Example 106 | (1R,2S)-1-[4-[2-[3- (flu...)
Affinity DataEC50:  0.977nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412222(US10399939, Example 102 | (1S,2R)-1-[4-[2-[3- (flu...)
Affinity DataEC50:  8.12nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412249(US10399939, Example 128 | (5R,6R)-5-(6-(2-(3- (flu...)
Affinity DataEC50:  12.5nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412252(US10399939, Example 131 | (5S,6R)-5-(4-((1-(3- flu...)
Affinity DataEC50:  13.8nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412228(US10399939, Example 108 | (5S,6S)-6-(4,4- difluoro...)
Affinity DataEC50:  14.6nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412224(US10399939, Example 104 | (1R,2R)-1-[2,6- difluoro...)
Affinity DataEC50:  15.6nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412227(US10399939, Example 107 | (5R,6R)-5-(4-(2-(3- (flu...)
Affinity DataEC50:  16.4nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412240(US10399939, Example 119 | (5R,6R)-5-(2-fluoro-4- (...)
Affinity DataEC50:  16.5nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412244(US10399939, Example 123 | (5R,6S)-5-(4-((S)-2- ((R...)
Affinity DataEC50:  16.9nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412256(US10399939, Example 135 | (7S,8R)-8-(4-(2-(3- (flu...)
Affinity DataEC50:  29.8nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412223(US10399939, Example 103 | (1S,2R)-1-[4-[2-[3- (flu...)
Affinity DataEC50:  38.6nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412236(US10399939, Example 115 | (5S,6R)-5-(4-(2-(3- (flu...)
Affinity DataEC50:  39.4nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412232(US10399939, Example 111 | (5R,6S)-5-(4-(2-(3- (flu...)
Affinity DataEC50:  47nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412233(US10399939, Example 112 | (5R,6S)-5-(4-(2-(3- (chl...)
Affinity DataEC50:  50.9nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412254(US10399939, Example 133 | 4-((1R,2S)-1-(4-(2-(3- (...)
Affinity DataEC50:  53nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412237(US10399939, Example 116 | (5S,6R)-5-(4-(2-(3- (dif...)
Affinity DataEC50: >100nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412250(US10399939, Example 129 | (5S,6R)-5-(4-((1-(3- flu...)
Affinity DataEC50: >100nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412246(US10399939, Example 125 | (5R,6S)-5-(4-(((R)-1- ((...)
Affinity DataEC50: >100nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412257(US10399939, Example 136 | (7R,8S)-8-(4-(2-(3- (flu...)
Affinity DataEC50:  186nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412258(US10399939, Example 137 | (5R,6S)-5-(4-((2-(3- (fl...)
Affinity DataEC50:  186nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM412260(US10399939, Example 139 | (5R,6S)-5-(4-((2-((R)- 3...)
Affinity DataEC50:  228nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent