Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 1828
TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 340000BDBM340000(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Affinity DataIC50: 0.200nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339977BDBM339977(5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-(5-chloro-1...)
Affinity DataIC50: 0.200nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 340008BDBM340008((S)-5-((2-Aminopropyl)amino)-3-(5-(pyridin-3-yl)-1...)
Affinity DataIC50: 0.300nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339978BDBM339978(5-{[(2S)-2- aminopropyl]amino}-3-(4- bromo-1H-indo...)
Affinity DataIC50: 0.400nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339998BDBM339998(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Affinity DataIC50: 0.5nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339999BDBM339999(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Affinity DataIC50: 0.5nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50075732BDBM50075732(CHEMBL3414584 | US9775839, 2.1)
Affinity DataIC50: 0.5nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339979BDBM339979(US9775839, 7.4 | 5-[(3-aminotetrahydro-2H- pyran-4...)
Affinity DataIC50: 0.5nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339981BDBM339981(5-{[(3R,4R)-3- aminotetrahydro-2H- pyran-4-yl]amin...)
Affinity DataIC50: 0.600nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339975BDBM339975((S)-5-((2-Aminopropyl)amino)-3-(5-(1-methyl-1H-pyr...)
Affinity DataIC50: 0.600nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50075733BDBM50075733(CHEMBL3415610 | US9775839, 8.5)
Affinity DataIC50: 0.700nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339974BDBM339974((S)-5-((2-aminopropyl)amino)-3-(5-bromo-1H-indol-2...)
Affinity DataIC50: 0.800nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339997BDBM339997(5-(((3S,4S)-4-amino-1,1- dioxidotetrahydro-2H- thi...)
Affinity DataIC50: 0.800nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339984BDBM339984(5-{[(3S,4S)-4-amino-1,1- dioxidotetrahydro-2H- thi...)
Affinity DataIC50: 0.900nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339994BDBM339994(5-{[(2R)-2-amino-3- methoxypropyl]amino}-3- (4-met...)
Affinity DataIC50: 1nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339982BDBM339982(5-{[(3R,4R)-3- aminotetrahydro-2H- pyran-4-yl]amin...)
Affinity DataIC50: 1.20nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339986BDBM339986(5-{[(3S,4S)-4-amino-1,1- dioxidotetrahydro-2H- thi...)
Affinity DataIC50: 1.20nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339983BDBM339983(5-{[(3S,4S)-4-amino-1,1- dioxidotetrahydro-2H- thi...)
Affinity DataIC50: 1.30nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339993BDBM339993(5-{[(3R,4R)-3- aminotetrahydro-2H- pyran-4-yl]amin...)
Affinity DataIC50: 1.30nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339989BDBM339989(5-{[(1R,2S)-2- aminocyclohexyl]amino}- 3-(4-methyl...)
Affinity DataIC50: 1.30nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 340003BDBM340003(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Affinity DataIC50: 1.60nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339991BDBM339991(5-{[(3R,4R)-3- aminotetrahydro-2H- pyran-4-yl]amin...)
Affinity DataIC50: 2.10nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 340006BDBM340006(5-(((3S,4S)-4-Amino-1,1-dioxidotetrahydro-2H-thiop...)
Affinity DataIC50: 2.20nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50075944BDBM50075944(CHEMBL3415609 | US9775839, 3.1)
Affinity DataIC50: 2.5nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339996BDBM339996(5-(((3R,4R)-3-aminotetrahydro-2H-pyran-4-yl)amino)...)
Affinity DataIC50: 3nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339985BDBM339985(5-{[(3S,4S)-4-amino-1,1- dioxidotetrahydro-2H- thi...)
Affinity DataIC50: 3.10nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339976BDBM339976((S)-5-((2-Aminopropyl)amino)-3-(5-(2-(2-oxopyrroli...)
Affinity DataIC50: 3.70nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 340001BDBM340001(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Affinity DataIC50: 4.10nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 340002BDBM340002(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Affinity DataIC50: 4.10nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 340004BDBM340004(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Affinity DataIC50: 5.20nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50201711BDBM50201711(CHEMBL3951922 | US9775839, 2.2)
Affinity DataIC50: 5.20nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339979BDBM339979(US9775839, 7.4 | 5-[(3-aminotetrahydro-2H- pyran-4...)
Affinity DataIC50: 5.90nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339987BDBM339987((R)-5-((2-Amino-3-methoxypropyl)amino)-3-(1H-indol...)
Affinity DataIC50: 6.40nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339995BDBM339995(5-[(2-Aminoethyl)amino]-3-(5-fluoro-1H-indol-2-yl)...)
Affinity DataIC50: 13.4nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 340009BDBM340009(5-(2-Aminoethylamino)-3-(1H-indol-2-yl)pyrazine-2-...)
Affinity DataIC50: 13.9nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 340011BDBM340011((R)-5-((1-amino-3-methoxypropan-2-yl)amino)-3-(1H-...)
Affinity DataIC50: 21.6nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 340012BDBM340012((S)-5-((1-amino-3- methoxypropan-2- yl)amino)-3-(1...)
Affinity DataIC50: 27.2nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 340010BDBM340010(5-{[2-Amino-3-(methylsulfonyl)propyl]amino}-3-(1H-...)
Affinity DataIC50: 29.1nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339988BDBM339988(5-{[(3R,4R)-4-amino-1,1- dioxidotetrahydro-2H- thi...)
Affinity DataIC50: 124nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339970BDBM339970((R)-tert-butyl (1-((6-chloro-5-cyanopyrazin-2-yl)a...)
Affinity DataIC50: 528nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 340005BDBM340005((S)-5-((2-Aminopropyl)amino)-3-(phenylethynyl)pyra...)
Affinity DataIC50: 992nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 340007BDBM340007((2-(6-(((3S,4S)-4-amino-1,1-dioxidotetrahydro-2H-t...)
Affinity DataIC50: 2.47E+3nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent