Compile Data Set for Download or QSAR
maximum 50k data
Found 47 Enz. Inhib. hit(s) with all data for entry = 11001
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584223((2R,3R,4S,5R)-2-(4-amino-5-fluoro- 7H-pyrrolo[2,3-...)
Affinity DataIC50:  0.700nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584222((2R,3R,4S,5R)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50:  2nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584223((2R,3R,4S,5R)-2-(4-amino-5-fluoro- 7H-pyrrolo[2,3-...)
Affinity DataIC50:  2.80nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584221((2R,3R,4S,5S)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50:  3nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584225((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50:  3nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584222((2R,3R,4S,5R)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50:  4.10nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584226((2R,3R,4S,5R)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50:  4.40nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584224((2S,3S,4R,5R)-2-((R)-1- (bicyclo[4.2.0]octa-1(6),2...)
Affinity DataIC50:  5nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584226((2R,3R,4S,5R)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50:  6nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584221((2R,3R,4S,5S)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50:  6.20nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584241((2R,3R,4S,5R)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50:  6.60nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584225((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50:  6.80nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584248((2S,3S,4R,5R)-2-((S)-(5,6-dihydro-4H- cyclopenta[d...)
Affinity DataIC50:  9nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584248((2S,3S,4R,5R)-2-((S)-(5,6-dihydro-4H- cyclopenta[d...)
Affinity DataIC50:  9.30nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584232((2R,3R,4S,5R)-2-(4-amino-5-bromo- 7H-pyrrolo[2,3-d...)
Affinity DataIC50:  11nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584233((2R,3R,4S,5R)-2-(4-amino-5-iodo-7H- pyrrolo[2,3-d]...)
Affinity DataIC50:  12nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584252((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50:  17.6nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584232((2R,3R,4S,5R)-2-(4-amino-5-bromo- 7H-pyrrolo[2,3-d...)
Affinity DataIC50:  20nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584225((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50:  23.7nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584224((2S,3S,4R,5R)-2-((R)-1- (bicyclo[4.2.0]octa-1(6),2...)
Affinity DataIC50:  24.3nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584233((2R,3R,4S,5R)-2-(4-amino-5-iodo-7H- pyrrolo[2,3-d]...)
Affinity DataIC50:  31nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584227(7-((2R,3R,4S,5R)-5-((R)- bicyclo[4.2.0]octa-1(6),2...)
Affinity DataIC50:  32nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584250((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50:  37.6nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584231((2R,3S,4R,5R)-2-[(R)-4- bicyclo[4.2.0]octa-1,3,5- ...)
Affinity DataIC50:  46nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584247((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50:  51nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584229(7-((2R,3R,4S,5S)-5-((R)-1- (bicyclo[4.2.0]octa-1(6...)
Affinity DataIC50:  57nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584244((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50:  74nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584245((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50:  78nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584227(7-((2R,3R,4S,5R)-5-((R)- bicyclo[4.2.0]octa-1(6),2...)
Affinity DataIC50:  121nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584249((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1,3,5-tri...)
Affinity DataIC50:  134nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584228(7-((2R,3R,4S,5R)-5-((R)- bicyclo[4.2.0]octa-1(6),2...)
Affinity DataIC50:  148nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584228(7-((2R,3R,4S,5R)-5-((R)- bicyclo[4.2.0]octa-1(6),2...)
Affinity DataIC50:  153nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584249((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1,3,5-tri...)
Affinity DataIC50:  164nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584239((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1,3,5-tri...)
Affinity DataIC50:  181nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584229(7-((2R,3R,4S,5S)-5-((R)-1- (bicyclo[4.2.0]octa-1(6...)
Affinity DataIC50:  189nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584251((2R,3R,4S,5R)-2-(4-(2- (benzyloxy)ethyl)-7H-pyrrol...)
Affinity DataIC50:  200nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584234((2R,3R,4S,5R)-2-(4-amino-5- (trifluoromethyl)-7H-p...)
Affinity DataIC50:  221nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM584237((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50:  230nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584243((2R,3S,4R,5R)-2-((S)- bicyclo[4.2.0]octa-1,3,5-tri...)
Affinity DataIC50:  274nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584231((2R,3S,4R,5R)-2-[(R)-4- bicyclo[4.2.0]octa-1,3,5- ...)
Affinity DataIC50:  287nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584234((2R,3R,4S,5R)-2-(4-amino-5- (trifluoromethyl)-7H-p...)
Affinity DataIC50:  368nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584238((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1,3,5-tri...)
Affinity DataIC50:  392nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584230(3-(7-((2R,3R,4S,5R)-5-((R)- bicyclo[4.2.0]octa-1(6...)
Affinity DataIC50:  697nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584236((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50:  1.03E+3nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584235((2R,3R,4S,5S)-2-(4-amino-7H- pyrrolo [2,3-d]pyrimi...)
Affinity DataIC50:  1.24E+3nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584242((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50:  2.06E+3nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM584246((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50:  2.52E+3nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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