Compile Data Set for Download or QSAR
Report error Found 47 Enz. Inhib. hit(s) with all data for entry = 11001
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584223BDBM584223((2R,3R,4S,5R)-2-(4-amino-5-fluoro- 7H-pyrrolo[2,3-...)
Affinity DataIC50: 0.700nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584222BDBM584222((2R,3R,4S,5R)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50: 2nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584223BDBM584223((2R,3R,4S,5R)-2-(4-amino-5-fluoro- 7H-pyrrolo[2,3-...)
Affinity DataIC50: 2.80nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584221BDBM584221((2R,3R,4S,5S)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50: 3nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584225BDBM584225((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50: 3nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584222BDBM584222((2R,3R,4S,5R)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50: 4.10nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584226BDBM584226((2R,3R,4S,5R)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50: 4.40nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584224BDBM584224((2S,3S,4R,5R)-2-((R)-1- (bicyclo[4.2.0]octa-1(6),2...)
Affinity DataIC50: 5nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584226BDBM584226((2R,3R,4S,5R)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50: 6nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584221BDBM584221((2R,3R,4S,5S)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50: 6.20nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584241BDBM584241((2R,3R,4S,5R)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50: 6.60nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584225BDBM584225((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50: 6.80nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584248BDBM584248((2S,3S,4R,5R)-2-((S)-(5,6-dihydro-4H- cyclopenta[d...)
Affinity DataIC50: 9nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584248BDBM584248((2S,3S,4R,5R)-2-((S)-(5,6-dihydro-4H- cyclopenta[d...)
Affinity DataIC50: 9.30nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584232BDBM584232((2R,3R,4S,5R)-2-(4-amino-5-bromo- 7H-pyrrolo[2,3-d...)
Affinity DataIC50: 11nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584233BDBM584233((2R,3R,4S,5R)-2-(4-amino-5-iodo-7H- pyrrolo[2,3-d]...)
Affinity DataIC50: 12nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584252BDBM584252((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50: 17.6nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584232BDBM584232((2R,3R,4S,5R)-2-(4-amino-5-bromo- 7H-pyrrolo[2,3-d...)
Affinity DataIC50: 20nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584225BDBM584225((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50: 23.7nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584224BDBM584224((2S,3S,4R,5R)-2-((R)-1- (bicyclo[4.2.0]octa-1(6),2...)
Affinity DataIC50: 24.3nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584233BDBM584233((2R,3R,4S,5R)-2-(4-amino-5-iodo-7H- pyrrolo[2,3-d]...)
Affinity DataIC50: 31nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584227BDBM584227(7-((2R,3R,4S,5R)-5-((R)- bicyclo[4.2.0]octa-1(6),2...)
Affinity DataIC50: 32nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584250BDBM584250((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50: 37.6nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584231BDBM584231((2R,3S,4R,5R)-2-[(R)-4- bicyclo[4.2.0]octa-1,3,5- ...)
Affinity DataIC50: 46nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584247BDBM584247((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50: 51nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584229BDBM584229(7-((2R,3R,4S,5S)-5-((R)-1- (bicyclo[4.2.0]octa-1(6...)
Affinity DataIC50: 57nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584244BDBM584244((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50: 74nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584245BDBM584245((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50: 78nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584227BDBM584227(7-((2R,3R,4S,5R)-5-((R)- bicyclo[4.2.0]octa-1(6),2...)
Affinity DataIC50: 121nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584249BDBM584249((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1,3,5-tri...)
Affinity DataIC50: 134nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584228BDBM584228(7-((2R,3R,4S,5R)-5-((R)- bicyclo[4.2.0]octa-1(6),2...)
Affinity DataIC50: 148nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584228BDBM584228(7-((2R,3R,4S,5R)-5-((R)- bicyclo[4.2.0]octa-1(6),2...)
Affinity DataIC50: 153nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584249BDBM584249((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1,3,5-tri...)
Affinity DataIC50: 164nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584239BDBM584239((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1,3,5-tri...)
Affinity DataIC50: 181nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584229BDBM584229(7-((2R,3R,4S,5S)-5-((R)-1- (bicyclo[4.2.0]octa-1(6...)
Affinity DataIC50: 189nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584251BDBM584251((2R,3R,4S,5R)-2-(4-(2- (benzyloxy)ethyl)-7H-pyrrol...)
Affinity DataIC50: 200nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584234BDBM584234((2R,3R,4S,5R)-2-(4-amino-5- (trifluoromethyl)-7H-p...)
Affinity DataIC50: 221nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584237BDBM584237((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50: 230nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584243BDBM584243((2R,3S,4R,5R)-2-((S)- bicyclo[4.2.0]octa-1,3,5-tri...)
Affinity DataIC50: 274nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584231BDBM584231((2R,3S,4R,5R)-2-[(R)-4- bicyclo[4.2.0]octa-1,3,5- ...)
Affinity DataIC50: 287nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584234BDBM584234((2R,3R,4S,5R)-2-(4-amino-5- (trifluoromethyl)-7H-p...)
Affinity DataIC50: 368nMAssay Description:HotSpot Assay. Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584238BDBM584238((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1,3,5-tri...)
Affinity DataIC50: 392nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584230BDBM584230(3-(7-((2R,3R,4S,5R)-5-((R)- bicyclo[4.2.0]octa-1(6...)
Affinity DataIC50: 697nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584236BDBM584236((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50: 1.03E+3nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584235BDBM584235((2R,3R,4S,5S)-2-(4-amino-7H- pyrrolo [2,3-d]pyrimi...)
Affinity DataIC50: 1.24E+3nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584242BDBM584242((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50: 2.06E+3nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 584246BDBM584246((2R,3S,4R,5R)-2-((R)- bicyclo[4.2.0]octa-1(6),2,4-...)
Affinity DataIC50: 2.52E+3nMAssay Description:Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2023
Entry Details
US Patent