Compile Data Set for Download or QSAR
Report error Found 190 Enz. Inhib. hit(s) with all data for entry = 233
TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244193BDBM244193(n-(3,4-dichlorobenzyl)-5,5-dimethyl-2-((tetrahydro...)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244250BDBM244250(n-((r)-1-(3-chlorophenyl)ethyl)-5-methyl-2-((tetra...)
Affinity DataIC50: 1.54nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244182BDBM244182((r)-n-(1-(3-fluoro-5-(methylsulfonyl)phenyl)ethyl)...)
Affinity DataIC50: 2nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 243225BDBM243225((r)-n-(1-(3-chlorophenyl)ethyl)-5,5-dimethyl-2-((t...)
Affinity DataIC50: 2nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 243205BDBM243205((s)-n-(1-(3-chlorophenyl)-2-hydroxyethyl)-5,5-dime...)
Affinity DataIC50: 4nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 243224BDBM243224(n-(3-chlorobenzyl)-5,5-dimethyl-2-((tetrahydro-2h-...)
Affinity DataIC50: 6nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244176BDBM244176(n-(3-chloro-5-(methylsulfonyl)benzyl)-5,5-dimethyl...)
Affinity DataIC50: 6nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244191BDBM244191(n-(4-chloro-3-fluorobenzyl)-5,5-dimethyl-2-((tetra...)
Affinity DataIC50: 6nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244190BDBM244190(n-(4-bromobenzyl)-5,5-dimethyl-2-((tetrahydro-2h-p...)
Affinity DataIC50: 7nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244184BDBM244184((s)-n-(2-hydroxy-1-(3-(methylsulfonyl)phenyl)ethyl...)
Affinity DataIC50: 7nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 243216BDBM243216(n-(3-chloro-5-fluorobenzyl)-5,5-dimethyl-2-((tetra...)
Affinity DataIC50: 8nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244198BDBM244198((r)-5,5-dimethyl-n-(1-(3-(methylsulfonyl)phenyl)et...)
Affinity DataIC50: 9nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244195BDBM244195((s)-n-(1-(3-fluorophenyl)-2-hydroxyethyl)-5,5-dime...)
Affinity DataIC50: 9nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 243231BDBM243231(n-(4-chlorobenzyl)-5,5-dimethyl-2-((tetrahydro-2h-...)
Affinity DataIC50: 10nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244188BDBM244188(5,5-dimethyl-2-((tetrahydro-2h-pyran-4-yl)amino)-n...)
Affinity DataIC50: 10nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244199BDBM244199(5,5-dimethyl-2-((tetrahydro-2h-pyran-4-yl)amino)-n...)
Affinity DataIC50: 11nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244161BDBM244161(n-(3-carbamoylbenzyl)-5,5-dimethyl-2-((tetrahydro-...)
Affinity DataIC50: 11nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244200BDBM244200(5,5-dimethyl-n-(4-phenoxybenzyl)-2-((tetrahydro-2h...)
Affinity DataIC50: 11nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244167BDBM244167(n-(1-(2-fluorobenzyl)-1h-pyrazol-4-yl)-2'-((te...)
Affinity DataIC50: 12nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244004BDBM244004((s)-n-(2-hydroxy-1-phenylethyl)-2'-((tetrahydr...)
Affinity DataIC50: 13nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 243244BDBM243244((r)-n-(1-((2-fluorophenyl)sulfonyl)piperidin-3-yl)...)
Affinity DataIC50: 13nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 243226BDBM243226((r)-5,5-dimethyl-n-(1-phenylethyl)-2-((tetrahydro-...)
Affinity DataIC50: 14nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244207BDBM244207((r)-n-(1-(2-fluorobenzyl)pyrrolidin-3-yl)-5,5-dime...)
Affinity DataIC50: 14nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 243204BDBM243204((s)-n-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-((t...)
Affinity DataIC50: 14nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 243235BDBM243235((s)-n-(2-amino-1-phenylethyl)-5,5-dimethyl-2-((tet...)
Affinity DataIC50: 14nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244178BDBM244178(n-(3-(ethylsulfonyl)benzyl)-5,5-dimethyl-2-((tetra...)
Affinity DataIC50: 16nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244194BDBM244194((s)-n-(2-hydroxy-1-(m-tolyl)ethyl)-5,5-dimethyl-2-...)
Affinity DataIC50: 16nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 243223BDBM243223(n-(3-fluorobenzyl)-5,5-dimethyl-2-((tetrahydro-2h-...)
Affinity DataIC50: 16nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 243239BDBM243239(5,5-dimethyl-n-(1-phenylcyclopropyl)-2-((tetrahydr...)
Affinity DataIC50: 17nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 243207BDBM243207(5,5-dimethyl-n-(3-(methylsulfonyl)benzyl)-2-((tetr...)
Affinity DataIC50: 18nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244204BDBM244204(5,5-dimethyl-2-((tetrahydro-2h-pyran-4-yl)amino)-n...)
Affinity DataIC50: 19nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244196BDBM244196(5,5-dimethyl-n-(4-methylbenzyl)-2-((tetrahydro-2h-...)
Affinity DataIC50: 21nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 243222BDBM243222(n-(3,5-difluorobenzyl)-5,5-dimethyl-2-((tetrahydro...)
Affinity DataIC50: 21nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244203BDBM244203((r)-n-(1-(4-cyanophenyl)ethyl)-5,5-dimethyl-2-((te...)
Affinity DataIC50: 21nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244005BDBM244005(n-(4-chlorobenzyl)-5-ethyl-5-methyl-2-((tetrahydro...)
Affinity DataIC50: 22nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 243227BDBM243227(n-(4-fluorobenzyl)-5,5-dimethyl-2-((tetrahydro-2h-...)
Affinity DataIC50: 22nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244107BDBM244107((s)-2-(cyclohexylamino)-n-(2-hydroxy-1-phenylethyl...)
Affinity DataIC50: 22nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244009BDBM244009((r)-5-ethyl-n-((s)-2-hydroxy-1-phenylethyl)-5-meth...)
Affinity DataIC50: 22nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 243212BDBM243212(5,5-dimethyl-n-((1r)-2-phenylcyclopropyl)-2-((tetr...)
Affinity DataIC50: 23nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244185BDBM244185((r)-n-(1-((3-chlorophenyl)sulfonyl)piperidin-3-yl)...)
Affinity DataIC50: 23nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 243245BDBM243245((r)-5,5-dimethyl-n-(1-(phenylsulfonyl)piperidin-3-...)
Affinity DataIC50: 27nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 243990BDBM243990((r)-methyl 3-((6-(((s)-2-hydroxy-1-phenylethyl)car...)
Affinity DataIC50: 30nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244003BDBM244003(n-(4-chlorobenzyl)-2'-((tetrahydro-2h-pyran-4-...)
Affinity DataIC50: 31nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 243249BDBM243249(n-(cyclohexylmethyl)-5,5-dimethyl-2-((tetrahydro-2...)
Affinity DataIC50: 31nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 243248BDBM243248(n-benzyl-5,5-dimethyl-2-((tetrahydro-2h-pyran-4-yl...)
Affinity DataIC50: 31nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244206BDBM244206((r)-5,5-dimethyl-n-(1-(4-(methylsulfonyl)phenyl)et...)
Affinity DataIC50: 32nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244172BDBM244172(n-(1-(3-chlorobenzyl)-5-(methylcarbamoyl)piperidin...)
Affinity DataIC50: 37nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244189BDBM244189(n-(4-cyanobenzyl)-5,5-dimethyl-2-((tetrahydro-2h-p...)
Affinity DataIC50: 38nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244202BDBM244202(n-(3-cyanobenzyl)-5,5-dimethyl-2-((tetrahydro-2h-p...)
Affinity DataIC50: 38nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 244177BDBM244177(5,5-dimethyl-n-(3-(propylsulfonyl)benzyl)-2-((tetr...)
Affinity DataIC50: 39nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

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