Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 10100
TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 0.600nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM513991(US11059827, Compound TSR-011)
Affinity DataIC50: 2.30nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 9.30nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410202(US10370379, Compound 19 | US11059827, Compound 19)
Affinity DataIC50: 100nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410184(5-((2R,4S)-4-fluoro-2-(5-fluoropyridin-3-yl)pyrrol...)
Affinity DataIC50: 100nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410185(US10370379, Compound 2 | US11059827, Compound 2)
Affinity DataIC50: 100nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410187(6-fluoro-5-((2R,4S)-4-fluoro-2-(5-fluoropyridin-3-...)
Affinity DataIC50: 100nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410189(5-((2R,4S)-2-(3-cyano-5-fluorophenyl)-4-fluoropyrr...)
Affinity DataIC50: 100nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410190(5-((2R,4S)-4-fluoro-2-(5-fluoro-2-methoxypyridin-3...)
Affinity DataIC50: 100nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410192(US10370379, Compound 9 | US11059827, Compound 9)
Affinity DataIC50: 100nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410193(US10370379, Compound 10 | US11059827, Compound 10)
Affinity DataIC50: 100nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410194(US10370379, Compound 11 | US11059827, Compound 11)
Affinity DataIC50: 100nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410195(US10370379, Compound 12 | US11059827, Compound 12)
Affinity DataIC50: 100nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410196(US10370379, Compound 13 | US11059827, Compound 13)
Affinity DataIC50: 100nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM514009(US11059827, Compound 15)
Affinity DataIC50: 100nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410199(US10370379, Compound 16 | US11059827, Compound 16)
Affinity DataIC50: 100nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410200(US10370379, Compound 17 | US11059827, Compound 17)
Affinity DataIC50: 100nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410201(US10370379, Compound 18 | US11059827, Compound 18)
Affinity DataIC50: 300nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410186((R)-5-(4,4-difluoro-2-(5-fluoropyridin-3-yl)pyrrol...)
Affinity DataIC50: 300nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410203(US10370379, Compound 20 | US11059827, Compound 20)
Affinity DataIC50: 300nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410204(US10370379, Compound 21 | US11059827, Compound 21)
Affinity DataIC50: 300nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410188(5-((2R,4S)-4-cyano-2-(2,5-difluorophenyl)pyrrolidi...)
Affinity DataIC50: 300nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410205(US10370379, Compound 22 | US11059827, Compound 22)
Affinity DataIC50: 300nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410191(5-((2R,4S)-4-fluoro-2-(5-fluoro-1-methyl-2-oxo-1,2...)
Affinity DataIC50: 300nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM410197(US10370379, Compound 14 | US11059827, Compound 14)
Affinity DataIC50: 300nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent