Compile Data Set for Download or QSAR
Report error Found 164 Enz. Inhib. hit(s) with all data for entry = 9533
Target5-hydroxytryptamine receptor 2A(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50459718BDBM50459718(CHEMBL4213379 | US10836764, Compound 106)
Affinity DataKi:  1.19nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472951BDBM472951((R)-4-isopentyl-6,6a,7,8,9,10-hexahydro-5H- pyrazi...)
Affinity DataKi:  1.28nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472955BDBM472955((R)-4-(cyclohexylmethyl)-6,6a,7,8,9,10- hexahydro-...)
Affinity DataKi:  1.39nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50459714BDBM50459714(CHEMBL4204710 | US10836764, Compound 149)
Affinity DataKi:  1.41nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50459710BDBM50459710(CHEMBL4212834 | US10836764, Compound 128)
Affinity DataKi:  1.65nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50459708BDBM50459708(CHEMBL4206126 | US10836764, Compound 152)
Affinity DataKi:  1.65nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 473018BDBM473018((R)-4-bromo-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1...)
Affinity DataKi:  1.90nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50459712BDBM50459712(CHEMBL4218374 | US10836764, Compound 173)
Affinity DataKi:  1.93nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472988BDBM472988((R)-4-ethyl-3-propyl-6,6a,7,8,9,10-hexahydro-5H- p...)
Affinity DataKi:  2.14nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50459710BDBM50459710(CHEMBL4212834 | US10836764, Compound 128)
Affinity DataKi:  2.15nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2B(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50459714BDBM50459714(CHEMBL4204710 | US10836764, Compound 149)
Affinity DataKi:  2.27nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472923BDBM472923((R)-4-pentyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Affinity DataKi:  2.30nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472949BDBM472949((R)-4-methyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Affinity DataKi:  2.47nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472913BDBM472913((R)-3-propyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Affinity DataKi:  2.5nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472948BDBM472948((R)-4-(2-fluorobenzyl)-6,6a,7,8,9,10-hexahydro- 5H...)
Affinity DataKi:  2.65nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 473021BDBM473021((R)-4-benzyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Affinity DataKi:  2.75nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2B(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472949BDBM472949((R)-4-methyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Affinity DataKi:  2.95nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 473013BDBM473013((R)-3-chloro-4-(3,3,3-trifluoropropyl)- 6,6a,7,8,9...)
Affinity DataKi:  3.67nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 473014BDBM473014((R)-8-methyl-4-(3,3,3-trifluoropropyl)- 6,6a,7,8,9...)
Affinity DataKi:  3.71nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472926BDBM472926((6aR)-4-(pentan-2-yl)-6,6a,7,8,9,10-hexahydro- 5H-...)
Affinity DataKi:  4.45nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472996BDBM472996((R,E)-4-(but-2-en-1-yl)-6,6a,7,8,9,10-hexahydro- 5...)
Affinity DataKi:  5.01nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50459716BDBM50459716(CHEMBL4217787 | US10836764, Compound 121)
Affinity DataKi:  5.20nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 473007BDBM473007((R)-4-phenethyl-6,6a,7,8,9,10-hexahydro-5H- pyrazi...)
Affinity DataKi:  5.52nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2B(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 473017BDBM473017((R)-3-(cyclopentylmethyl)-4-ethyl-6,6a,7,8,9,10- h...)
Affinity DataKi:  6.35nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472930BDBM472930((R)-4-propyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Affinity DataKi:  6.85nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472983BDBM472983(cyclobutyl((R)-6,6a,7,8,9,10-hexahydro-5H- pyrazin...)
Affinity DataKi:  7.42nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472921BDBM472921((R)-4-(2-methoxyethyl)-6,6a,7,8,9,10-hexahydro- 5H...)
Affinity DataKi:  7.76nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50459709BDBM50459709(CHEMBL4209052 | US10836764, Compound 137)
Affinity DataKi:  7.90nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472995BDBM472995((R)-4-(pyridin-2-ylmethyl)-6,6a,7,8,9,10- hexahydr...)
Affinity DataKi:  9.48nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2B(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472923BDBM472923((R)-4-pentyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Affinity DataKi:  9.53nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 473020BDBM473020((R)-4-(cyclohexylmethyl)-6,6a,7,8,9,10- hexahydro-...)
Affinity DataKi:  9.55nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472999BDBM472999((R)-4-cyclopentyl-6,6a,7,8,9,10-hexahydro-5H- pyra...)
Affinity DataKi:  9.89nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50459714BDBM50459714(CHEMBL4204710 | US10836764, Compound 149)
Affinity DataKi:  10.3nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472954BDBM472954((R)-4-(methoxymethyl)-6,6a,7,8,9,10-hexahydro- 5H-...)
Affinity DataKi:  10.5nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472929BDBM472929((R)-4-butyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1...)
Affinity DataKi:  10.6nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2B(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472930BDBM472930((R)-4-propyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Affinity DataKi:  10.8nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 473007BDBM473007((R)-4-phenethyl-6,6a,7,8,9,10-hexahydro-5H- pyrazi...)
Affinity DataKi:  10.8nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 473015BDBM473015((R)-4-chloro-2-(methylthio)-6,6a,7,8,9,10- hexahyd...)
Affinity DataKi:  11.2nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2B(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472989BDBM472989((R)-3-benzyl-4-ethyl-6,6a,7,8,9,10-hexahydro-5H- p...)
Affinity DataKi:  11.4nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 473016BDBM473016((R)-4-(cyclopentylmethyl)-6,6a,7,8,9,10- hexahydro...)
Affinity DataKi:  11.4nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2B(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472928BDBM472928((R)-4-isopropyl-6,6a,7,8,9,10-hexahydro-5H- pyrazi...)
Affinity DataKi:  12.5nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2B(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 473018BDBM473018((R)-4-bromo-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1...)
Affinity DataKi:  13nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472997BDBM472997((R)-4-(isopropoxymethyl)-6,6a,7,8,9,10- hexahydro-...)
Affinity DataKi:  13.8nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50459713BDBM50459713(CHEMBL4213447 | US10836764, Compound 176)
Affinity DataKi:  14.1nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2B(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472929BDBM472929((R)-4-butyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1...)
Affinity DataKi:  14.5nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472927BDBM472927((R)-4-ethyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1...)
Affinity DataKi:  16.1nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472990BDBM472990((6aR)-4-((tetrahydro-2H-pyran-2-yl)methyl)- 6,6a,7...)
Affinity DataKi:  16.1nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2B(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472996BDBM472996((R,E)-4-(but-2-en-1-yl)-6,6a,7,8,9,10-hexahydro- 5...)
Affinity DataKi:  16.3nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2B(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50459707BDBM50459707(CHEMBL4208452 | US10836764, Compound 115)
Affinity DataKi:  16.7nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2B(Human)
Arena Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 472927BDBM472927((R)-4-ethyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1...)
Affinity DataKi:  19.3nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

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