Compile Data Set for Download or QSAR
Report error Found 181 Enz. Inhib. hit(s) with all data for entry = 2708
TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 376564BDBM376564(US9918985, Example 20a Isomer 1)
Affinity DataIC50: 0.570nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50393100BDBM50393100(CHEMBL2152915 | US10231967, Example 125 | US991898...)
Affinity DataIC50: 0.630nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136858BDBM136858(US8865911, 94 Isomer 2 | US8865911, 94 Isomer 1 | ...)
Affinity DataIC50: 0.700nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136800BDBM136800(US8865911, 48 Isomer 2 | US10231967, Example 48-Is...)
Affinity DataIC50: 0.700nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136863BDBM136863(US8865911, 100 | US10231967, Example 100 | US99189...)
Affinity DataIC50: 0.720nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136856BDBM136856(US8865911, 92 Isomer 2 | US10231967, Example 92-Is...)
Affinity DataIC50: 0.840nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50393102BDBM50393102(US8865911, 20t | US8865911, 20t Isomer 1 | US88659...)
Affinity DataIC50: 0.890nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 369599BDBM369599(US10231967, Example 106 | 3-[(1r,4r)-4″-Amin...)
Affinity DataIC50: 1nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136739BDBM136739(US8865911, 20e | US10231967, Example 119 | US99189...)
Affinity DataIC50: 1.10nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136830BDBM136830(US8865911, 68 Isomer 1 | US8865911, 67 | US1023196...)
Affinity DataIC50: 1.20nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 41537BDBM41537(US8865911, 114 | US10231967, Example 114 | US99189...)
Affinity DataIC50: 1.20nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136871BDBM136871(US8865911, 108 | US10231967, Example 108 | US99189...)
Affinity DataIC50: 1.30nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136833BDBM136833(US8865911, 73 | US9000182, 21, isomer 1 | US102319...)
Affinity DataIC50: 1.30nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136789BDBM136789(US8865911, 30c | US9918985, Example 30e)
Affinity DataIC50: 1.40nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50393103BDBM50393103(CHEMBL2151058 | US10231967, Example 20z | US991898...)
Affinity DataIC50: 1.40nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136849BDBM136849(US8865911, 86 | US10231967, Example 86 | US9918985...)
Affinity DataIC50: 1.5nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136861BDBM136861(US8865911, 98 | US10231967, Example 98 | US9918985...)
Affinity DataIC50: 1.5nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50393104BDBM50393104(CHEMBL2152918 | US10231967, Example 20aa | US99189...)
Affinity DataIC50: 1.60nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50393100BDBM50393100(CHEMBL2152915 | US10231967, Example 125 | US991898...)
Affinity DataIC50: 1.60nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136858BDBM136858(US8865911, 94 Isomer 2 | US8865911, 94 Isomer 1 | ...)
Affinity DataIC50: 1.80nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136830BDBM136830(US8865911, 68 Isomer 1 | US8865911, 67 | US1023196...)
Affinity DataIC50: 2nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136847BDBM136847(US8865911, 84 | US10231967, Example 84 | US9918985...)
Affinity DataIC50: 2.10nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136854BDBM136854(US8865911, 91 | US10231967, Example 91 | US9918985...)
Affinity DataIC50: 2.20nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50393099BDBM50393099(CHEMBL2152914 | US10231967, Example 122 | US991898...)
Affinity DataIC50: 2.20nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 376580BDBM376580(US9918985, Example 20i Isomer 2)
Affinity DataIC50: 2.20nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136850BDBM136850(US8865911, 87 | US10231967, Example 87 | US9918985...)
Affinity DataIC50: 2.20nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136736BDBM136736(US8865911, 20b | US10231967, Example 20b | US99189...)
Affinity DataIC50: 2.30nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50393106BDBM50393106(CHEMBL2152920 | US10231967, Example 72 | US9918985...)
Affinity DataIC50: 2.30nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136739BDBM136739(US8865911, 20e | US10231967, Example 119 | US99189...)
Affinity DataIC50: 2.30nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136743BDBM136743(US8865911, 20g | US10231967, Example 20g | US99189...)
Affinity DataIC50: 2.5nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136834BDBM136834(US8865911, 74 | US9918985, Example 74)
Affinity DataIC50: 2.60nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136851BDBM136851(US8865911, 88 | US10231967, Example 88 | US9918985...)
Affinity DataIC50: 2.80nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136829BDBM136829(US8865911, 66 Isomer 1 | US8865911, 65 | US1023196...)
Affinity DataIC50: 2.90nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136947BDBM136947(US8865911, 97 Isomer 2 | US10231967, Example 96 | ...)
Affinity DataIC50: 3.10nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136848BDBM136848(US8865911, 85 | US10231967, Example 85 | US9918985...)
Affinity DataIC50: 3.10nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136852BDBM136852(US8865911, 89 | US10231967, Example 89 | US9918985...)
Affinity DataIC50: 3.30nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136865BDBM136865(US8865911, 102 | US10231967, Example 102 | US99189...)
Affinity DataIC50: 3.30nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136835BDBM136835(US8865911, 76 Isomer 2 | US8865911, 76 Isomer 1 | ...)
Affinity DataIC50: 3.40nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136862BDBM136862(US8865911, 99 | US10231967, Example 99 | US9918985...)
Affinity DataIC50: 3.90nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50393101BDBM50393101(US8865911, 20i | US8865911, 20i Isomer 1 | US88659...)
Affinity DataIC50: 4.80nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136768BDBM136768(US8865911, 20y | US10231967, Example 20y | US99189...)
Affinity DataIC50: 4.90nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 376718BDBM376718(US9918985, Example 50 Isomer 2)
Affinity DataIC50: 5nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136788BDBM136788(US8865911, 30d | US10231967, Example 30d | US99189...)
Affinity DataIC50: 5.20nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136737BDBM136737(US8865911, 20c | US10231967, Example 20c | US99189...)
Affinity DataIC50: 5.20nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136787BDBM136787(US8865911, 30b | US10231967, Example 30c | US99189...)
Affinity DataIC50: 5.30nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136859BDBM136859(US8865911, 95 | US10231967, Example 95 | US9918985...)
Affinity DataIC50: 5.30nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136741BDBM136741(US8865911, 20f | US10231967, Example 20f | US99189...)
Affinity DataIC50: 5.5nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136835BDBM136835(US8865911, 76 Isomer 2 | US8865911, 76 Isomer 1 | ...)
Affinity DataIC50: 5.70nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136829BDBM136829(US8865911, 66 Isomer 1 | US8865911, 65 | US1023196...)
Affinity DataIC50: 5.70nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136824BDBM136824(US8865911, 61 | US10231967, Example 61 | US9918985...)
Affinity DataIC50: 5.90nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

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