Compile Data Set for Download or QSAR
Report error Found 198 Enz. Inhib. hit(s) with all data for entry = 10434
TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535532BDBM535532(N-(2-(4,4-Difluoropiperidin-1-yl)-6- methylpyrimid...)
Affinity DataIC50: 17nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 50561924BDBM50561924(US11236069, Example 6-29 | CHEMBL4750775)
Affinity DataIC50: 17nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 50561923BDBM50561923(US11236069, Example 6-24-1 | CHEMBL4751673)
Affinity DataIC50: 17.4nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 50561926BDBM50561926(US11236069, Example 11-25 | CHEMBL4776120)
Affinity DataIC50: 17.6nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 50561925BDBM50561925(US11236069, Example 11-4 | CHEMBL4743241)
Affinity DataIC50: 18nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 50561927BDBM50561927(US11236069, Example 11-62 | CHEMBL4740783)
Affinity DataIC50: 18nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535640BDBM535640(N-(2-(4-Fluoropiperidin-1-yl)- 6-methylpyrimidin-4...)
Affinity DataIC50: 20nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535665BDBM535665((R)-N-(2-(3,3-Difluoroazetidin- 1-yl)-6-methylpyri...)
Affinity DataIC50: 20nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535616BDBM535616((R)-N-(2-(3-Fluoro-3- methylpyrrolidin-1-yl)-6- me...)
Affinity DataIC50: 20nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535618BDBM535618(N-(2-((1R,5S)-3- Azabicyclo[3.1.0]hexan-3-yl)- 6-m...)
Affinity DataIC50: 20nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535564BDBM535564((R)-N-(2-(4,4- Difluoropiperidin-1- yl)pyrimidin-4...)
Affinity DataIC50: 21nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535652BDBM535652(N-(2-(4,4-Difluoropiperidin-1- yl)-3-fluoropyridin...)
Affinity DataIC50: 22nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535645BDBM535645(N-(2-(4-Fluoropiperidin-1- yl)pyrimidin-4-yl)-4-((...)
Affinity DataIC50: 22nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535646BDBM535646(N-(2-(4,4-Difluoropiperidin-1- yl)pyrimidin-4-yl)-...)
Affinity DataIC50: 22nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535689BDBM535689(N-(2-(4,4-Difluoropiperidin-1- yl)pyridin-4-yl)-4-...)
Affinity DataIC50: 23nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535693BDBM535693(N-(2-(4,4-Difluoropiperidin-1- yl)pyrimidin-4-yl)-...)
Affinity DataIC50: 23nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535597BDBM535597(N-(2-(3,3-Difluoroazetidin-1- yl)pyrimidin-4-yl)-4...)
Affinity DataIC50: 23nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535584BDBM535584(N-(2-(3,3-Difluoroazetidin-1-yl)-6- methylpyrimidi...)
Affinity DataIC50: 23nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535592BDBM535592(4-((2-Hydroxyethyl)sulfonamido)-N- (2-isopropyl-6-...)
Affinity DataIC50: 27nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535690BDBM535690(4-(N-(2- Hydroxyethyl)sulfamoyl)-2-(6- azaspiro[2....)
Affinity DataIC50: 27nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535560BDBM535560(4-(((R)-2-hydroxy-1- methylethyl)sulfonamido)-N- (...)
Affinity DataIC50: 28nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535526BDBM535526(N-(2-(4,4-Difluoropiperidin-1- yl)pyridin-4-yl)-4-...)
Affinity DataIC50: 29nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535563BDBM535563((S)-N-(2-(4,4- Difluoropiperidin-1- yl)pyrimidin-4...)
Affinity DataIC50: 31nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535595BDBM535595(N-(2-(3-Fluoroazetidin-1-yl)-6- methylpyrimidin-4-...)
Affinity DataIC50: 32nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535551BDBM535551(N-(2-(4,4-Difluoropiperidin-1- yl)-6-methylpyrimid...)
Affinity DataIC50: 32nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535520BDBM535520(N-(6-Methyl-2-(3,3,3- trifluoropropoxy)pyrimidin-4...)
Affinity DataIC50: 32nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535538BDBM535538((R)-4-((2- Hydroxyethyl)sulfonamido)- N-(2-(2- met...)
Affinity DataIC50: 32nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535633BDBM535633(N-(2-((1S,6R)-2- Azabicyclo[4.1.0]heptan-2-yl)- 6-...)
Affinity DataIC50: 33nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535619BDBM535619(N-(2-(3,3-Difluoropyrrolidin-1- yl)-6-methylpyrim-...)
Affinity DataIC50: 33nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535656BDBM535656(N-(2-(4,4-Difluoropiperidin-1- yl)-6-methylpyrimid...)
Affinity DataIC50: 34nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535631BDBM535631(N-(2-((1R)-1-Hydroxy-3- azabicyclo[4.1.0]heptan-3-...)
Affinity DataIC50: 34nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535666BDBM535666((S)-N-(2-(3,3-Difluoroazetidin- 1-yl)-6-methylpyri...)
Affinity DataIC50: 34nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535703BDBM535703(2-(6-Azaspiro[2.5]octan-6- yl)-N-(2-(4,4-difluoro-...)
Affinity DataIC50: 35nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535632BDBM535632(N-(2-((1R,6R)-3- Azabicyclo[4.1.0]heptan-3-yl)- 6-...)
Affinity DataIC50: 35nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535634BDBM535634((S)-4-((2- Hydroxyethyl)sulfonamido)-N- (6-methyl-...)
Affinity DataIC50: 35nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535591BDBM535591((S)-4-((2-Hydroxyethyl)sulfonamido)-N- (2-(2-methy...)
Affinity DataIC50: 37nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535558BDBM535558(4-(((R)-2-Hydroxy-1- methylethyl)sulfonamido)-N- (...)
Affinity DataIC50: 37.3nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535570BDBM535570(N-(2-(4,4-Difluoropiperidin-1- yl)-6-methylpyridin...)
Affinity DataIC50: 38.4nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535557BDBM535557(4-(((S)-2-Hydroxy-1- methylethyl)sulfonamido)-N- (...)
Affinity DataIC50: 39nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535553BDBM535553(N-(2-(4,4-Difluoropiperidin-1- yl)-6-methylpyrimid...)
Affinity DataIC50: 39nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535555BDBM535555(N-(2-(4,4-Difluoropiperidin-1- yl)-6-methylpyrimid...)
Affinity DataIC50: 39nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535546BDBM535546(N-(2-(4,4-Difluoropiperidin-1- yl)-6-methylpyrimid...)
Affinity DataIC50: 40nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535710BDBM535710(4-(Azetidin-3-ylsulfonyl)-N-(2-(4,4- difluoropiper...)
Affinity DataIC50: 40nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535562BDBM535562((R)-N-(2-(4-Fluoropiperidin-1- yl)-6-methylpyrimid...)
Affinity DataIC50: 41nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535644BDBM535644((R)-N-(2-(3-Fluoro-3- methylpiperidin-1-yl)-6- met...)
Affinity DataIC50: 41nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535705BDBM535705(4-(Cyclopropanesulfonimidoyl)- N-(2-(4,4-difluorop...)
Affinity DataIC50: 42nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535691BDBM535691(4-(N-(2- Hydroxyethyl)sulfamoyl)-N-(6- methyl-2-(3...)
Affinity DataIC50: 42nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535660BDBM535660((R)-N-(2-(3,3-Difluoroazetidin- 1-yl)-6-methylpyri...)
Affinity DataIC50: 42nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535536BDBM535536(N-(2-(4,4-Difluoropiperidin-1- yl)-6-methylpyrimid...)
Affinity DataIC50: 42nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535624BDBM535624((S)-N-(2-(3-Cyanopiperidin-1- yl)-6-methylpyrimidi...)
Affinity DataIC50: 43nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

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