Compile Data Set for Download or QSAR
Report error Found 83 Enz. Inhib. hit(s) with all data for entry = 10921
TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578446BDBM578446((R) N-(4-(1H-pyrazol-4-yl)phenyl)-2-(4-chloropheny...)
Affinity DataIC50: 1.20nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578479BDBM578479((S) N-(2-(2-(dimethylamino)ethoxy)-5-fluoro-4-(1H-...)
Affinity DataIC50: 1.60nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578424BDBM578424(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-chlorophenyl)-2...)
Affinity DataIC50: 1.70nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578438BDBM578438((R) N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphen...)
Affinity DataIC50: 1.80nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578449BDBM578449(3-(2-((4-(1H-pyrazol-4-yl)phenyl)amino)-1-(methyla...)
Affinity DataIC50: 1.90nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578470BDBM578470(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphenyl)-...)
Affinity DataIC50: 2.40nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578435BDBM578435((R) N-(4-(1H-pyrazol-4-yl)phenyl)-2-((2-(dimethyla...)
Affinity DataIC50: 2.90nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578410BDBM578410((S) N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphen...)
Affinity DataIC50: 3nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578409BDBM578409(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(2-methoxyphenyl)-...)
Affinity DataIC50: 3nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578438BDBM578438((R) N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphen...)
Affinity DataIC50: 3nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578454BDBM578454(N-(2-(2-(dimethylamino)ethoxy)-5-fluoro-4-(1H-pyra...)
Affinity DataIC50: 3nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578415BDBM578415(US11479533, Example 11 | US11479533, Example 21 | ...)
Affinity DataIC50: 3.10nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578420BDBM578420(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-chlorophenyl)-2...)
Affinity DataIC50: 3.5nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578411BDBM578411(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphenyl)-...)
Affinity DataIC50: 4nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578415BDBM578415(US11479533, Example 11 | US11479533, Example 21 | ...)
Affinity DataIC50: 4nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578423BDBM578423(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(4-fluorophenyl)-2...)
Affinity DataIC50: 4.80nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578430BDBM578430(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphenyl)-...)
Affinity DataIC50: 5.30nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578476BDBM578476(N-(3-methoxy-4-(1H-pyrazol-4-yl)phenyl)-2-((2-meth...)
Affinity DataIC50: 5.30nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578417BDBM578417(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(ethylamino)-2-(3-...)
Affinity DataIC50: 6.30nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578421BDBM578421(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(4-chlorophenyl)-2...)
Affinity DataIC50: 6.30nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578461BDBM578461(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphenyl)-...)
Affinity DataIC50: 6.5nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578418BDBM578418(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(methylamino)-2-(m...)
Affinity DataIC50: 6.80nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578435BDBM578435((R) N-(4-(1H-pyrazol-4-yl)phenyl)-2-((2-(dimethyla...)
Affinity DataIC50: 7.70nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578453BDBM578453(N-(2-(3-(dimethylamino)propoxy)-5-fluoro-4-(1H-pyr...)
Affinity DataIC50: 7.70nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578471BDBM578471(N-(2-(2-(dimethylamino)ethoxy)-5-fluoro-4-(1H-pyra...)
Affinity DataIC50: 8.10nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578457BDBM578457(N-(4-(1H-pyrazol-4-yl)phenyl)-2-((3-(dimethylamino...)
Affinity DataIC50: 8.70nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578426BDBM578426(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(4-chlorophenyl)-2...)
Affinity DataIC50: 8.90nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578422BDBM578422(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-fluorophenyl)-2...)
Affinity DataIC50: 10nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578431BDBM578431(N-(4-(1H-pyrazol-4-yl)phenyl)-2-((2-(dimethylamino...)
Affinity DataIC50: 10nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578409BDBM578409(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(2-methoxyphenyl)-...)
Affinity DataIC50: 12nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578412BDBM578412((R) N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphen...)
Affinity DataIC50: 12nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578460BDBM578460(N-(4-(1H-pyrazol-4-yl)phenyl)-2-((2-amino-2-oxoeth...)
Affinity DataIC50: 12nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578433BDBM578433((R) N-(4-(1H-pyrazol-4-yl)phenyl)-2-((2-methoxyeth...)
Affinity DataIC50: 12nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578440BDBM578440(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(2-methoxypyridin-...)
Affinity DataIC50: 14nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578413BDBM578413(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(4-methoxyphenyl)-...)
Affinity DataIC50: 15.4nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578455BDBM578455(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphenyl)-...)
Affinity DataIC50: 16nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578458BDBM578458(N-(4-(1H-pyrazol-4-yl)phenyl)-2-((2-(dimethylamino...)
Affinity DataIC50: 16nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578411BDBM578411(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphenyl)-...)
Affinity DataIC50: 17nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578472BDBM578472(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphenyl)-...)
Affinity DataIC50: 17nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578475BDBM578475(N-(3-fluoro-4-(1H-pyrazol-4-yl)phenyl)-2-((2-metho...)
Affinity DataIC50: 17nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578447BDBM578447(N-(2-fluoro-5-methoxy-4-(1H-pyrazol-4-yl)phenyl)-2...)
Affinity DataIC50: 18nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578441BDBM578441(Methyl 3-(2-((4-(1H-pyrazol-4-yl)phenyl)amino)-1-(...)
Affinity DataIC50: 18nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578427BDBM578427(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-fluoro-4-methox...)
Affinity DataIC50: 21nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578414BDBM578414(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(ethylamino)-2-(4-...)
Affinity DataIC50: 21nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578428BDBM578428(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-(difluoromethox...)
Affinity DataIC50: 22nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578439BDBM578439((S) N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphen...)
Affinity DataIC50: 22nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578445BDBM578445((S) N-(4-(1H-pyrazol-4-yl)phenyl)-2-(4-chloropheny...)
Affinity DataIC50: 24nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578419BDBM578419(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(ethylamino)-2-(3-...)
Affinity DataIC50: 24nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578444BDBM578444(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methyl-1H-indaz...)
Affinity DataIC50: 29nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578466BDBM578466(N-(4-(1H-pyrazol-4-yl)phenyl)-2-((2-methoxyethyl)(...)
Affinity DataIC50: 30nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

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