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Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 2914
TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM50195239(CHEMBL3972563 | US10287258, Example 29 | US1066924...)
Affinity DataIC50:  2.40nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385058((2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-ox...)
Affinity DataIC50:  3.16nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  4.47nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385076(BDBM445984 | US10287258, Example 36 | US11667615, ...)
Affinity DataIC50:  5.01nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385055((2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo...)
Affinity DataIC50:  5.13nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385077(BDBM445985 | US10287258, Example 37 | US11667615, ...)
Affinity DataIC50:  5.25nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM50195246(CHEMBL3980602 | US10287258, Example 16 | US1066924...)
Affinity DataIC50:  5.75nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385057((2S)-N-[(1S)-1-Cyano-2-{4-[3-(cyclopropylmethyl)-2...)
Affinity DataIC50:  6.31nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM50195248(CHEMBL3891374 | US10287258, Example 27 | US1066924...)
Affinity DataIC50:  6.61nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385053((2S)-N-[(1S)-1-Cyano-2-(4-{3-[2-(dimethylamino)eth...)
Affinity DataIC50:  7.24nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385061((2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-ox...)
Affinity DataIC50:  8.13nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385068((2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(2,2,2-trifluor...)
Affinity DataIC50:  8.13nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385052((2S)-N-[(1S)-1-Cyano-2-{4-[3-(2,2-difluoroethyl)-7...)
Affinity DataIC50:  10nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM50195240(CHEMBL3960432 | US10287258, Example 3 | US10669245...)
Affinity DataIC50:  10.2nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385065((2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(tetrahydro-2H-...)
Affinity DataIC50:  10.7nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM50195238(CHEMBL3962926 | US10287258, Example 20 | US1066924...)
Affinity DataIC50:  12.6nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385049((2S)-N-{(1S)-1-Cyano-2-[4-(4-methyl-3-oxo-3,4-dihy...)
Affinity DataIC50:  12.9nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385066((2S)-N-{(1S)-2-[4-(7-Chloro-3-methyl-2-oxo-2,3-dih...)
Affinity DataIC50:  13.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM50195244(CHEMBL3926554 | US10287258, Example 24 | US1066924...)
Affinity DataIC50:  13.8nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385059((2S)-N- [(1S)-1-Cyano-2-{4-[2-oxo-3-(propan-2-yl)-...)
Affinity DataIC50:  14.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM50195245(CHEMBL3972158 | US10287258, Example 5 | US10669245...)
Affinity DataIC50:  16.2nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM50195242(CHEMBL3917575 | US10287258, Example 14 | US1066924...)
Affinity DataIC50:  16.6nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385062((2S)-N-{(1S)-1-Cyano-2-[4-(5-cyanothiophen-2-yl)ph...)
Affinity DataIC50:  19.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385050((2S)-N-{(1S)-1-Cyano-2-[4-(3-ethyl-7-methyl-2-oxo-...)
Affinity DataIC50:  21.4nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385071((2S)-N-{(1S)-2-[4'-(Azetidin-1-ylsulfonyl)biphenyl...)
Affinity DataIC50:  21.4nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385075(US10287258, Example 35 | US10669245, Example 35 | ...)
Affinity DataIC50:  24.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM50195236(CHEMBL3927609 | US10287258, Example 1 | US10669245...)
Affinity DataIC50:  35.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM50195255(CHEMBL3945475 | US10287258, Example 6 | US10669245...)
Affinity DataIC50:  36.3nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385070((2S)-N-{(1S)-1-Cyano-2-[4'-(methylsulfonyl)bipheny...)
Affinity DataIC50:  37.2nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385072((2S)-N-[(1S)-1-Cyano-2-(4'-fluorobiphenyl-4-yl)eth...)
Affinity DataIC50:  42.7nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385074(US10287258, Example 34 | US10669245, Example 34 | ...)
Affinity DataIC50:  60.3nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM50195263(CHEMBL3942969 | US10287258, Example 33 | US1066924...)
Affinity DataIC50:  61.7nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385063((2S)-N-[(1S)-2-(4'-Carbamoy1-3'-fluorobiphenyl-4-y...)
Affinity DataIC50:  67.6nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385047((2S)-N-[(1S)-1-Cyano-2-(3',4'-difluorobiphenyl-4-y...)
Affinity DataIC50:  69.2nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385044(4′-[(2S)-2-Cyano-2-{[(2S)-1,4-oxazepan-2-ylc...)
Affinity DataIC50:  79.4nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385048((2S)-N-{(1S)-1-Cyano-2-[4-(6-cyanopyridin-3-yl)phe...)
Affinity DataIC50:  87.1nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385051((2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-hydroxy-2-methylpr...)
Affinity DataIC50:  89.1nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent