Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 9076
TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline Intellectual Property (No. 2)

US Patent
LigandPNGBDBM439190((R)-2-(1-(1-(Bicyclo[2.2.2]octan-1-ylmethyl)piperi...)
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline Intellectual Property (No. 2)

US Patent
LigandPNGBDBM439169((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline Intellectual Property (No. 2)

US Patent
LigandPNGBDBM439197((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline Intellectual Property (No. 2)

US Patent
LigandPNGBDBM439192((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline Intellectual Property (No. 2)

US Patent
LigandPNGBDBM439163((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline Intellectual Property (No. 2)

US Patent
LigandPNGBDBM439133((R)-2-(1-(1-(Cyclopentylmethyl)piperidin-4-yl)ethy...)
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline Intellectual Property (No. 2)

US Patent
LigandPNGBDBM439165((R)-2-(1-(1-(Cyclopropylmethyl)piperidin-4-yl)ethy...)
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline Intellectual Property (No. 2)

US Patent
LigandPNGBDBM439164((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline Intellectual Property (No. 2)

US Patent
LigandPNGBDBM439129((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline Intellectual Property (No. 2)

US Patent
LigandPNGBDBM439132((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline Intellectual Property (No. 2)

US Patent
LigandPNGBDBM439130((R)-2-(1-(1-(Cyclobutylmethyl)piperidin-4-yl)ethyl...)
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2020
Entry Details
US Patent