BDBM439169 (R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-2-(1-(1-((1-methylcyclopentyl)methyl)piperidin-4-yl)ethyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-c]azepin-4-one::US10604531, Example 8

SMILES C[C@H](C1CCN(CC2(C)CCCC2)CC1)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 439169   

TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Glaxosmithkline Intellectual Property (No. 2)

US Patent
LigandPNGBDBM439169((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)
Affinity DataIC50: <10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent