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Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 11768
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645627(US20240018138, Compound 109 | US20240018138, Compo...)
Affinity DataIC50: 15.1nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645624(US20240018138, Compound 102)
Affinity DataIC50: 27.2nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645627(US20240018138, Compound 109 | US20240018138, Compo...)
Affinity DataIC50: 51.7nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645631(US20240018138, Compound 107)
Affinity DataIC50: 51.8nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645632(US20240018138, Compound 108)
Affinity DataIC50: 62.3nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645655(US20240018138, Compound 123)
Affinity DataIC50: 133nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645640(US20240018138, Compound 116)
Affinity DataIC50: 157nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645648(US20240018138, Compound 122)
Affinity DataIC50: 205nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645641(US20240018138, Compound 117)
Affinity DataIC50: 221nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645636(US20240018138, Compound 112)
Affinity DataIC50: 236nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645644(US20240018138, Compound 118)
Affinity DataIC50: 316nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645646(US20240018138, Compound 120)
Affinity DataIC50: 361nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645658(US20240018138, Compound 126)
Affinity DataIC50: 387nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645635(US20240018138, Compound 111)
Affinity DataIC50: 401nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645645(US20240018138, Compound 119)
Affinity DataIC50: 470nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645638(US20240018138, Compound 114)
Affinity DataIC50: 718nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645657(US20240018138, Compound 125)
Affinity DataIC50: 756nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645656(US20240018138, Compound 124)
Affinity DataIC50: 1.33E+3nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645639(US20240018138, Compound 115)
Affinity DataIC50: 1.38E+3nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645634(US20240018138, Compound 110)
Affinity DataIC50: 2.23E+3nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645628(US20240018138, Compound 105)
Affinity DataIC50: 3.82E+3nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645637(US20240018138, Compound 113)
Affinity DataIC50: 4.23E+3nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645625(US20240018138, Compound 103)
Affinity DataIC50: 4.33E+3nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645630(US20240018138, Compound 106)
Affinity DataIC50: 4.55E+3nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM645647(US20240018138, Compound 121)
Affinity DataIC50: 7.63E+3nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent