Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 1175
TargetNeprilysin(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 155343BDBM155343(US9006249, Example 49-2 | US9603819, Example 49-2)
Affinity DataIC50: 0.0300nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 309469BDBM309469(US9603819, Example 49-1 | (2R,4S)-5-(3′-Chlo...)
Affinity DataIC50: 0.0400nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 155344BDBM155344(US9006249, Example 49-3 | US9603819, Example 49-3)
Affinity DataIC50: 0.300nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 153108BDBM153108(US8993631, 16-5 | US9006249, Example 3-32 | US9603...)
Affinity DataIC50: 1nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 309463BDBM309463(US9603819, Example 3-60)
Affinity DataIC50: 7.30nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 309468BDBM309468(US9603819, Example 13-1 | (2R,4S)-5-biphenyl-4-yl-...)
Affinity DataIC50: 14nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 153116BDBM153116(US8993631, 19 | US9006249, Example 7-1 | US9603819...)
Affinity DataIC50: 93nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 153117BDBM153117(US8993631, 20 | US9006249, Example 9-1 | US9603819...)
Affinity DataIC50: 142nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 153107BDBM153107(US8993631, 16-3 | US9006249, Example 3-6 | US96038...)
Affinity DataIC50: 250nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 153113BDBM153113(US8993631, 15-1 | US9006249, Example 2-1 | US96038...)
Affinity DataIC50: 267nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 153112BDBM153112(US8993631, 14-1 | US9006249, Example 1-1 | US96038...)
Affinity DataIC50: 283nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 153114BDBM153114(US8993631, 17 | US9006249, Example 5-1 | US9603819...)
Affinity DataIC50: 350nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 153115BDBM153115(US8993631, 18-1 | US9006249, Example 6-1 | US96038...)
Affinity DataIC50: 450nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent