Compile Data Set for Download or QSAR
Report error Found 75 Enz. Inhib. hit(s) with all data for entry = 1593
TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331979(US10195201, Example 19 | (R)- or (S)-2- (3,4-dimet...)
Affinity DataKi:  0.200nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331979(US10195201, Example 19 | (R)- or (S)-2- (3,4-dimet...)
Affinity DataKi:  0.400nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331979(US10195201, Example 19 | (R)- or (S)-2- (3,4-dimet...)
Affinity DataKi:  0.400nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331979(US10195201, Example 19 | (R)- or (S)-2- (3,4-dimet...)
Affinity DataKi:  1.40nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332018((R)- or (S)-6''- (1-(3-fluoro- 4-(trifluoro- metho...)
Affinity DataKi:  1.80nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331979(US10195201, Example 19 | (R)- or (S)-2- (3,4-dimet...)
Affinity DataKi:  2.30nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332022((R)- or (S)-2- methyl-6''-(1- (4-(trifluoro- metho...)
Affinity DataKi:  4.10nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331967(US10195201, Example 6 | US10195201, Example 7)
Affinity DataKi:  6nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332020((R)- or (S)-6''- (1-(3-fluoro- 4-(trifluoro- metho...)
Affinity DataKi:  7.5nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331967(US10195201, Example 6 | US10195201, Example 7)
Affinity DataKi:  10nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331967(US10195201, Example 6 | US10195201, Example 7)
Affinity DataKi:  12nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331967(US10195201, Example 6 | US10195201, Example 7)
Affinity DataKi:  13nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332012((R)- or (S)-6''- (1-(4-(difluoro- methoxy)-3- fluo...)
Affinity DataKi:  13nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331967(US10195201, Example 6 | US10195201, Example 7)
Affinity DataKi:  13nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332004(US10195201, Example 30 | US10195201, Example 31)
Affinity DataKi:  16nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331964(US10195201, Example 4 | US10195201, Example 5)
Affinity DataKi:  18nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331964(US10195201, Example 4 | US10195201, Example 5)
Affinity DataKi:  19nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331964(US10195201, Example 4 | US10195201, Example 5)
Affinity DataKi:  20nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332010((R)- or (S)-2- methyl-6''-(1-(4- (trifluoromethyl)...)
Affinity DataKi:  20nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332014(US10195201, Example 37 | (R)- or (S)-6''- (1-(4-(1...)
Affinity DataKi:  20nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331975(US10195201, Example 14 | US10195201, Example 15)
Affinity DataKi:  21nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331967(US10195201, Example 6 | US10195201, Example 7)
Affinity DataKi:  21nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331964(US10195201, Example 4 | US10195201, Example 5)
Affinity DataKi:  22nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331975(US10195201, Example 14 | US10195201, Example 15)
Affinity DataKi:  24nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332016(US10195201, Example 39 | (R)- or (S)-6''- (1-(4-(d...)
Affinity DataKi:  30nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332004(US10195201, Example 30 | US10195201, Example 31)
Affinity DataKi:  39nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331975(US10195201, Example 14 | US10195201, Example 15)
Affinity DataKi:  45nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332020((R)- or (S)-6''- (1-(3-fluoro- 4-(trifluoro- metho...)
Affinity DataKi:  45nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331975(US10195201, Example 14 | US10195201, Example 15)
Affinity DataKi:  46nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331967(US10195201, Example 6 | US10195201, Example 7)
Affinity DataKi:  57nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331961(US10195201, Example 1)
Affinity DataKi:  60nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331967(US10195201, Example 6 | US10195201, Example 7)
Affinity DataKi:  62nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332010((R)- or (S)-2- methyl-6''-(1-(4- (trifluoromethyl)...)
Affinity DataKi:  64nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332014(US10195201, Example 37 | (R)- or (S)-6''- (1-(4-(1...)
Affinity DataKi:  65nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331977(US10195201, Example 17 | (R)- or (S)-2- methyl-6-(...)
Affinity DataKi:  76nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331970(US10195201, Example 9 | US10195201, Example 10)
Affinity DataKi:  79nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331970(US10195201, Example 9 | US10195201, Example 10)
Affinity DataKi:  86nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331961(US10195201, Example 1)
Affinity DataKi:  96nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331977(US10195201, Example 17 | (R)- or (S)-2- methyl-6-(...)
Affinity DataKi:  106nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331982(US10195201, Example 21)
Affinity DataKi:  110nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331981(US10195201, Example 20)
Affinity DataKi:  123nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331970(US10195201, Example 9 | US10195201, Example 10)
Affinity DataKi:  159nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332016(US10195201, Example 39 | (R)- or (S)-6''- (1-(4-(d...)
Affinity DataKi:  174nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332022((R)- or (S)-2- methyl-6''-(1- (4-(trifluoro- metho...)
Affinity DataKi:  194nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332018((R)- or (S)-6''- (1-(3-fluoro- 4-(trifluoro- metho...)
Affinity DataKi:  212nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332012((R)- or (S)-6''- (1-(4-(difluoro- methoxy)-3- fluo...)
Affinity DataKi:  232nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331975(US10195201, Example 14 | US10195201, Example 15)
Affinity DataKi:  298nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332026(US10195201, Example 48)
Affinity DataKi:  312nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331977(US10195201, Example 17 | (R)- or (S)-2- methyl-6-(...)
Affinity DataKi:  340nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331969(US10195201, Example 8)
Affinity DataKi:  352nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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