BDBM331979 (R)- or (S)-2- (3,4-dimethoxy- benzyl)-6-(1-(1- (2-fluoro-4- (trifluoromethyl) phenyl)ethyl)- 1H-imidazol-4- yl)pyrimidin- 4(3H)-one::US10195201, Example 18::US10195201, Example 19
SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)-c2cn(cn2)C(C)c2ccc(cc2F)C(F)(F)F)cc1OC
InChI Key
Data 5 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 331979
Affinity DataKi: 0.200nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataKi: 1.40nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Affinity DataKi: 2.30nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair