Compile Data Set for Download or QSAR
Report error Found 368 Enz. Inhib. hit(s) with all data for entry = 1087
TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136108BDBM136108(US8853203, 123b | US9650377, Example 123b)
Affinity DataIC50: 1nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136115BDBM136115(US8853203, 128 | US9650377, Example 128)
Affinity DataIC50: 1nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136048BDBM136048(US8853203, 92 | US9650377, Example 92)
Affinity DataIC50: 1nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136055BDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50: 2nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136055BDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50: 2nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136132BDBM136132(US8853203, 96-2 | US9650377, Example 96-2)
Affinity DataIC50: 2nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136055BDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50: 2nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136140BDBM136140(US8853203, 129 | US9650377, Example 129)
Affinity DataIC50: 2nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136049BDBM136049(US8853203, 93 | US9650377, Example 93)
Affinity DataIC50: 3nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136055BDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50: 3nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136106BDBM136106(US8853203, 123 | US9650377, Example 123)
Affinity DataIC50: 3nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136034BDBM136034(US8853203, 88a | US9650377, Example 88a)
Affinity DataIC50: 5nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136105BDBM136105(US8853203, 122 | US9650377, Example 122)
Affinity DataIC50: 5nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136113BDBM136113(US8853203, 124 | US9650377, Example 124)
Affinity DataIC50: 5nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 308239BDBM308239(US9650377, Example 126)
Affinity DataIC50: 6nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136055BDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50: 6nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136131BDBM136131(US8853203, 143 | US8853203, 96-1 | US9650377, Exam...)
Affinity DataIC50: 6nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136055BDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50: 7nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 135998BDBM135998(US8853203, 53 | US9650377, Example 53)
Affinity DataIC50: 7nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136114BDBM136114(US8853203, 127 | US9650377, Example 127)
Affinity DataIC50: 7nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136078BDBM136078(US8853203, 104 | US9650377, Example 104)
Affinity DataIC50: 7nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136103BDBM136103(US8853203, 120 | US9650377, Example 120)
Affinity DataIC50: 7nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 135975BDBM135975(US8853203, 29 | US9650377, Example 39)
Affinity DataIC50: 8nMAssay Description:Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136109BDBM136109(US8853203, 123c | US9650377, Example 123c)
Affinity DataIC50: 8nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136020BDBM136020(US8853203, 75 | US9650377, Example 75)
Affinity DataIC50: 9nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136047BDBM136047(US8853203, 91 | US9650377, Example 91)
Affinity DataIC50: 9nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 308212BDBM308212(US9650377, Example 109)
Affinity DataIC50: 10nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 308098BDBM308098(US9650377, Example 32)
Affinity DataIC50: 10nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 308166BDBM308166(US9650377, Example 90)
Affinity DataIC50: 10nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 135999BDBM135999(US8853203, 54 | US9650377, Example 54)
Affinity DataIC50: 11nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 308172BDBM308172(US9650377, Example 95-2 | 2-(3-cyclopropyl-1H-1,2,...)
Affinity DataIC50: 11nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 308234BDBM308234(US9650377, Example 123d)
Affinity DataIC50: 11nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136107BDBM136107(US8853203, 123a | US9650377, Example 123a)
Affinity DataIC50: 12nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136031BDBM136031(US8853203, 86 | US9650377, Example 86)
Affinity DataIC50: 12nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 135979BDBM135979(US8853203, 33 | US9650377, Example 33)
Affinity DataIC50: 13nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136104BDBM136104(US8853203, 121 | US9650377, Example 121)
Affinity DataIC50: 14nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 135976BDBM135976(US8853203, 30 | US9650377, Example 49)
Affinity DataIC50: 14nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 135981BDBM135981(US8853203, 35 | US9650377, Example 35)
Affinity DataIC50: 14nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136054BDBM136054(US8853203, 98 | US9650377, Example 98)
Affinity DataIC50: 14nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 135981BDBM135981(US8853203, 35 | US9650377, Example 35)
Affinity DataIC50: 15nMAssay Description:Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 135951BDBM135951(US8853203, 5 | US9650377, Example 5)
Affinity DataIC50: 15nMAssay Description:Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136076BDBM136076(US8853203, 102 | US9650377, Example 102)
Affinity DataIC50: 16nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136055BDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50: 16nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 308252BDBM308252(US9650377, Example 139)
Affinity DataIC50: 17nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136033BDBM136033(US8853203, 88 | US9650377, Example 88j)
Affinity DataIC50: 17nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136077BDBM136077(US8853203, 103 | US9650377, Example 103)
Affinity DataIC50: 18nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136134BDBM136134(US8853203, 108 | US9650377, Example 108)
Affinity DataIC50: 18nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136137BDBM136137(US8853203, 118 | US9650377, Example 118)
Affinity DataIC50: 18nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136133BDBM136133(US8853203, 100 | US9650377, Example 100)
Affinity DataIC50: 19nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 136121BDBM136121(US8853203, 136 | US9650377, Example 136)
Affinity DataIC50: 19nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

Displayed 1 to 50 (of 368 total ) | Next | Last >>
Jump to: